Episodic memory effects of gamma frequency precuneus transcranial magnetic stimulation in Alzheimer's disease: A randomized multiple baseline study

Episodic memory decline is the prominent neuropsychological feature of typical Alzheimer's Disease (AD), for which current treatments have a limited clinical response. Recently, gamma entrainment therapy has been used as a non-invasive treatment in AD, providing evidence that it may have the potential to alleviate brain pathology and improve cognitive function in AD patients. At the same time, the precuneus (PC) has been recognized as a key area involved in AD related memory deficits and as a key node of the Default Mode Network. This study aimed to investigate the effectiveness of a 40 Hz Transcranial Magnetic Stimulation (TMS) intervention, delivered bilaterally to the precuneus for 10 days, in improving the patients' episodic memory performance. Secondary outcome variables investigated included general cognitive function, semantic and spatial memory, as well as attention and executive function. A concurrent multiple baseline design across five cases was employed. Four patients completed the study. Visual analysis combined with effect size indices were used to evaluate changes across phases. An increase in the average level of immediate recalled words was observed in three out of four patients. Effect size indices indicated significant improvement of attention skills in two patients. No treatment effect was observed for semantic and visual memory, or for executive function. An immediate treatment effect was observed in all patients' general cognitive function as assessed with the Alzheimer's Disease Assessment Scale (mean reduction of 5 points), which was maintained and improved further three months post-treatment. The neuropsychological evaluations indicated improved performance three months post-treatment in immediate and delayed recall, attention, phonological verbal fluency, anxiety, and neuropsychiatric symptoms. This study provides preliminary evidence for the efficacy of a novel non-pharmacological treatment using gamma-band TMS in addressing cognitive dysfunction in AD.     

An extinction-induced increase in an aggressive response with humans

Nine subjects, 14 to 18 yr old, pulled a knob on a schedule of monetary reinforcement. Concurrently, they escaped or avoided periodic presentations of a tone by pressing a button that required 1.5 lb (6.67 N) of force or by punching a padded cushion that required 20 lb (88.96 N) of force. The punching response was designated as an aggressive response because the force of this response together with its topography was comparable to responses of humans that deface objects and produce escape or counter aggression from other humans. It was found that button pressing was the preferred concurrent avoidance response and there were few punches. However, when the monetary reinforcer was discontinued (extinction) punching increased for seven of the nine subjects, but there was no consistent change in the rate of button pressing. When the punching response was replaced by another non-preferred but non-aggressive response, neither this response nor button pressing increased during extinction. Hence, the increase in punching during extinction cannot be attributed solely to the fact that it was a concurrent response or a non-preferred response.     

Adolescents: A Suppressed Minority Group

The recent antagonistic but equally meritorious arguments concerning the nature of the adolescent necessitates a new framework of analysis which would incorporate these apparent antagonisms. Cursory observations indicate that more fruitful results may be obtained if the adolescent is equated to a member of a suppressed minority group. A comparison of the characteristics of the adolescent peer group to those of a suppressed minority group reveals some striking similarities.     

Gods and REMS: The implications of recent dream research for the psychology of religion

Throughout history dreams have been primarily the province of religion. People in many cultures have looked to dreams as sources of spiritual insight and divine revelation. The relationship between traditional religious views of dreams and modern psychological views of dreams has long interested psychologists of religion—for dreams are a uniquely fertile subject for comparing religious and psychological understandings of human experience. In recent years there have been many revolutionary discoveries in dream research, discoveries that have taken us far beyond the seminal works of Freud, Jung, and the early sleep laboratory researchers. This essay describes the work of three leading contemporary dream researchers (neurophysiologist J. Allan Hobson, psychologist Stephen LaBerge, and anthropologist Barbara Tedlock) and evaluates the implications of their findings for our understanding of the religious dimensions of dreams. The essay concludes with some reflections on the valuable role of dream study in the psychology of religion. The primary claim is that recent dream research can make important contributions to current psychology of religion discussions about such issues as interdisciplinary inquiry, hermeneutics, the cross-cultural study of religious experience, the cultural and religious context of modern psychology, and the practical concerns of pastoral counselors.This essay is based on a paper presented on November 25 at the 1991 Annual Meeting of the American Academy of Religion, Kansas City, Missouri.     

Changing contexts and the field of community psychology

Conclusion The legacy of the Swampscott conference 25 years ago is palpable. The scientific accomplishments have been substantial. The four agendas I have presented for the future development of the field depend upon psychologists as individuals and psychologists as participants in our departments, colleges, universities, professional societies, and peer review panels to reduce the constraints that limit the definition and study of psychological phenomena in community settings (Schneider, 1990). As these constraints are addressed, new social norms can be established to expand and diversify the research process. There are some explicit positive side effects that can occur. A new working social structure can be created for how universities and communities can be resources for each other.The four topics I have presented are agendas for keeping at the task of generating active and expanding scientific traditions. These topics when addressed in the context of collaboration with other disciplines and citizens can develop an empirical base of shared wisdom about how to carry out community psychology research. In these ways the benefits of community psychology research can become more empowering for the public and more and more systemic for the scholar.These comments were presented as an Invited Address at the 2nd annual meeting of the American Psychological Society, June 8, 1990, Dallas, Texas.The following persons took time to read and comment on earlier drafts of these comments. I have benefited very much from their appraisals. Eileen Altman, Daniel Cervone, Seeley Chandler-Kelly, Nancy Dassoff, Penny Foster-Fishman, Steve Goldston, Peter Graves, Kenneth Heller, Robert E. Hess, David Henry, Ira Iscoe, Chris Keys, Benjamin Kleinmuntz, Ed Lichtenstein, Philip Mann, Kyoung Oh, Julian Rappaport, Dan Romer, Lonnie R. Snowden, Joseph P. Stokes, Edison J. Trickett, Abe Wandersman, and Marc Alan Zimmerman.     

An MMPI-based empirical model of malingering and deception

The empirically-based model of malingering and deception described by Rogers (1984b) was operationalized using MMPI and clinical interview data. Subjects (N = 159) were patients committed to an inpatient forensic hospital as ‘Incompetent to Stand Trial’ or ‘Not Guilty by Reason of Insanity’. Inter-rater reliability was acceptable for the 11 criteria used to define response styles. Each subject was categorized into one of five response style groups: ‘Reliable’, ‘Malingering’, ‘Defensive’, ‘Irrelevant’, or ‘Unclassifiable’. Factor analysis of the rating criteria yielded four factors, three of which are comparable to the assigned groups, providing some validation for the constructs underlying these groups.