Lapses of intention and performance variability reveal age-related increases in fluctuations of executive control

We examine the hypothesis that the efficiency of executive control processes is less stable over time in older than younger adults. An age-related decrease in the efficiency of executive control should result in an increase in performance variability in task conditions requiring the recruitment of executive control processes and not in task conditions requiring minimal involvement of executive control. Performance variability was similar for younger and older adults in task conditions requiring minimal executive control and greater for older than younger adults in task conditions requiring executive control. These and other data are consistent with the proposal that aging is associated with a decrease in the stability of executive control over time.     

Psychiatric and substance use disorders as risk factors for attempted suicide among adolescents: a case control study

The objective of this research was to test substance-related and non-substance-related psychiatric disorders as predictors of attempted suicide among adolescents. Ninety-six psychiatrically disordered suicide attempters were matched one-to-one to 96 psychiatrically disordered non-attempters on age, race, gender, and the presence/absence of major depression. Conditional logistic regression was used to test psychiatric risk factors for their power to predict attempted suicide among adolescents. Bipolar disorder, cocaine use disorders, and conduct disorder were found to be predictive of attempted suicide in univariate testing. Bipolar disorder, inhalant use disorders, cocaine use disorders, and hallucinogen use disorders were found to be predictive of attempted suicide, after adjusting for all other covariates. Loglinear analyses revealed high odds ratios associated with the comorbidities of alcohol use disorder with conduct disorder and drug use disorders with conduct disorder in both groups. Higher rates of cocaine use disorder/conduct disorder, hallucinogen use disorder/conduct disorder, and alcohol use disorder/ conduct disorder were found among suicide attempters. Evaluation of these particular comorbid conditions should be part of the adolescent suicide risk assessment.     

MMPI-A scores and high points of male juvenile delinquents: scales 4, 5, and 6 as markers of juvenile delinquency

The Minnesota Multiphasic Personality Inventory-Adolescent (MMPI-A) clinical, supplementary, and content scale score patterns for 655 male delinquents were examined. Low scores on Scale 5 (Masculinity/Femininity) were found to be the most frequent deviation, followed by elevations on Scales 6 (Paranoia) and 4 (Psychopathic Deviate). This is consistent with previous research, although the importance of Scale 5 deviations has been little noted because of the traditional focus on scale elevations only. Classification analysis indicated that a combination of MMPI-A scales discriminated between this delinquent sample and the normative sample, with a sensitivity of 90%-95% and a specificity of 80%-85%. This level of sensitivity was maintained in a replication sample (N = 473).     

Pharmacogenetics: ethical issues and policy options

Pharmacogenetics offers the prospect of an era of safer and more effective drugs, as well as more individualized use of drug therapies. Before the benefits of pharmacogenetics can be realized, the ethical issues that arise in research and clinical application of pharmacogenetic technologies must be addressed. The ethical issues raised by pharmacogenetics can be addressed under six headings: (1) regulatory oversight, (2) confidentiality and privacy, (3) informed consent, (4) availability of drugs, (5) access, and (6) clinicians' changing responsibilities in the era of pharmacogenetic medicine. We analyze each of these categories of ethical issues and provide policy approaches for addressing them.     

Concurrent validity of the Personality Assessment Inventory Alcohol Problems (ALC) Scale in a college student sample

The concurrent validity of the Alcohol Problems scale (ALC) was investigated in a college student sample (N = 200). The relationships between the ALC and associated features of alcohol problems (e.g., consumption patterns, expectancies, maladaptive coping, and stress) were examined. The validity of the ALC for identifying clinically significant alcohol problems (assessed with the Structured Clinical Interview for the fourth edition ofthe Diagnostic and Statistical Manual of Mental Disorders) was also examined. The ALC was related to the associated features and was a valid indicator of alcohol problems. T scores of 80, 85, and 90 had superior hit rates for alcohol abuse; and scores of 80, 85, and 90 had superior hit rates for alcohol dependence.     

Review of quantity and types of spirituality research in three health care databases (1962-1999): implications for the health care ministry

Using computer technology to identify the term "spiritual," these researchers present results of the 2306 citations and compare five criteria discovered with research reported in four pastoral counseling journals. The authors note the limitations of such a search and the possible implications of the findings for health care ministry.     

Validation of a brief measure of posttraumatic stress disorder: the Distressing Event Questionnaire (DEQ)

The Distressing Event Questionnaire (DEQ) is a brief instrument for assessing posttraumatic stress disorder (PTSD) according to criteria provided in Diagnostic and Statistical Manual of Mental Disorders (4th ed.). The DEQ possesses high internal consistency and exhibited satisfactory short-term temporal stability in studies with Vietnam War combat veterans and battered women. In a sample of Vietnam War veterans and 4 separate samples of abused women (with histories of incest, rape, intimate partner abuse, or prostitution and abuse), the DEQ exhibited very good discriminative validity when judged against structured interview assessment of PTSD. The DEQ exhibited strong convergent validity with other PTSD measures and other indexes of adjustment and also exhibited strong convergent validity as a measure of PTSD across ethnic groups in both the veteran sample and the combined women's sample.