Indistinguishability, Choices, and Logics of Agency

This paper deals with structures ${\langle{\bf T}, I\rangle}$ in which T is a tree and I is a function assigning each moment a partition of the set of histories passing through it. The function I is called indistinguishability and generalizes the notion of undividedness. Belnap’s choices are particular indistinguishability functions. Structures ${\langle{\bf T}, I\rangle}$ provide a semantics for a language ${\mathcal{L}}$ with tense and modal operators. The first part of the paper investigates the set-theoretical properties of the set of indistinguishability classes, which has a tree structure. The significant relations between this tree and T are established within a general theory of trees. The aim of second part is testing the expressive power of the language ${\mathcal{L}}$ . The natural environment for this kind of investigations is Belnap’s seeing to it that (stit). It will be proved that the hybrid extension of ${\mathcal{L}}$ (with a simultaneity operator) is suitable for expressing stit concepts in a purely temporal language.     

The anaphase promoting complex is required for memory function in mice

Learning and memory processes critically involve the orchestrated regulation of de novo protein synthesis. On the other hand it has become clear that regulated protein degradation also plays a major role in neuronal plasticity and learning behavior. One of the key pathways mediating protein degradation is proteosomal protein destruction. The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that targets proteins for proteosomal degradation by the 26S proteasome. While the APC/C is essential for cell cycle progression it is also expressed in postmitotic neurons where it has been implicated with axonal outgrowth and neuronal survival. In this study we addressed the role of APC/C in learning and memory function by generating mice that lack the essential subunit APC2 from excitatory neurons of the adult forebrain. Those animals are viable but exhibit a severe impairment in the ability to extinct fear memories, a process critical for the treatment of anxiety diseases such as phobia or post-traumatic stress disorder. Since deregulated protein degradation and APC/C activity has been implicated with neurodegeneration we also analyzed the effect of Apc2 deletion in a mouse model for Alzheimer's disease. In our experimental setting loss of APC2 form principle forebrain neurons did not affect the course of pathology in an Alzheimer's disease mouse model. In conclusion, our data provides genetic evidence that APC/C activity in the adult forebrain is required for cognitive function.     

Non-empirical theoretical virtues and the argument from underdetermination

The antirealist argument from the underdetermination of theories by data relies on the premise that the empirical content of a theory is the only determinant of its belief-worthiness (premise NN). Several authors have claimed that the antirealist cannot endorse NN, on pain of internal inconsistency. I concede this point. Nevertheless, this refutation of the underdetermination argument fails because there are weaker substitutes for NN that will serve just as well as a premise to the argument. On the other hand, antirealists have not made a convincing casefor NN (or its weaker substitutes) either. In particular, I criticize van Fraassen's recent claim that all ampliative rules in epistemology must be rejected on the grounds that they lead to incoherence. The status of the underdetermination argument remains unsettled.     

Creativity in Its Social Context: The Interplay of Organizational Norms,Situational Threat,and Gender

Past research has frequently made the assumptions that creativity is an individual, rather than social, behavior; that the factors shaping creative behavior influence everyone in the same way; and that these factors always have the same influence regardless of the situation. This research challenges all 3 of these assumptions. In an experiment, participants (n = 187) assumed the role of members of a business organization with either individualist or collectivist norms that was either under competitive threat or not. Results indicated that, when threat was absent, men exhibited more divergent thinking under individualist than collectivist norms. However, the reverse was true for women when threat was absent and for both sexes when their organization was under threat. Thus, a group norm emphasizing individuality can sometimes enhance divergent thinking performance. However, this influence is moderated by other situational factors such as competitive threat, and, possibly for reasons of differing socialization, does not appear to affect men and women equally.     

Does Ontology Rest on a Mistake?: Andre Gallois

I discuss Steve Yablo's defence of Carnap's distinction between internal and external questions. In the first section I set out what I take that distinction, as Carnap draws it, to be, and spell out a central motivation Carnap has for invoking it. In the second section I endorse, and augment, Yablo's response to Quine's arguments against Carnap. In the third section I say why Carnap's application of the distinction between internal and external questions runs into trouble. In the fourth section I spell out what I take to be Yablo's version of Carnap. In the last I say why that version is especially vulnerable to the objection raised in the second.     

A STAFF MANAGEMENT SYSTEM FOR MAINTAINING IMPROVEMENTS IN CONTINENCE WITH ELDERLY NURSING HOME RESIDENTS

We developed a staff management system for maintaining treatment gains achieved on a specialized continence unit located in a geriatric nursing home. Geriatric assistants learned to use a prompted voiding procedure to maintain improved dryness for 4 elderly residents. The staff management system included self-monitoring and recording of prompted voiding activities and supervisory monitoring and feedback based on group performance of these activities. Results show that the system was effective in maintaining prompted voiding activities with corresponding maintenance of improved patient continence. However, a gradual decline in staff performance was noted 4 to 5 months after the initiation of the system. During a subsequent phase of the study, provision of individual feedback restored staff performance to previous levels. Results are discussed in relation to the practicality of prompted voiding interventions in nursing home environments and the applicability of staff management systems in this setting.     

Sex and least preferred co-worker score effects in leadership behavior

This study investigated the subordinate liking and the leadership style of male and female managers in a simulated business activity. Sixty-seven female and 290 male undergraduate and graduate business students participated in this study. Female managers, on average, were not less well liked, nor were they more accommodative than male managers. Among managers classified as distinctly accommodative, females were not better liked than males; among managers classified as distinctly directive, females were significantly better liked than males. Under pressure to act in a directive manner, males tended to make use of their secondary leadership style as defined by F. E. Fiedler (1972), while females did not.