Non-empirical theoretical virtues and the argument from underdetermination

The antirealist argument from the underdetermination of theories by data relies on the premise that the empirical content of a theory is the only determinant of its belief-worthiness (premise NN). Several authors have claimed that the antirealist cannot endorse NN, on pain of internal inconsistency. I concede this point. Nevertheless, this refutation of the underdetermination argument fails because there are weaker substitutes for NN that will serve just as well as a premise to the argument. On the other hand, antirealists have not made a convincing casefor NN (or its weaker substitutes) either. In particular, I criticize van Fraassen's recent claim that all ampliative rules in epistemology must be rejected on the grounds that they lead to incoherence. The status of the underdetermination argument remains unsettled.     

A STAFF MANAGEMENT SYSTEM FOR MAINTAINING IMPROVEMENTS IN CONTINENCE WITH ELDERLY NURSING HOME RESIDENTS

We developed a staff management system for maintaining treatment gains achieved on a specialized continence unit located in a geriatric nursing home. Geriatric assistants learned to use a prompted voiding procedure to maintain improved dryness for 4 elderly residents. The staff management system included self-monitoring and recording of prompted voiding activities and supervisory monitoring and feedback based on group performance of these activities. Results show that the system was effective in maintaining prompted voiding activities with corresponding maintenance of improved patient continence. However, a gradual decline in staff performance was noted 4 to 5 months after the initiation of the system. During a subsequent phase of the study, provision of individual feedback restored staff performance to previous levels. Results are discussed in relation to the practicality of prompted voiding interventions in nursing home environments and the applicability of staff management systems in this setting.     

Cross‐cultural,population‐based study on adolescent body image and eating distress in Japan and Finland

This cross‐sectional population‐based survey compares the prevalence of self‐reported body image and eating distress symptoms among adolescents in Japan and Finland, and associations between emotional/behavioral problems, body image and eating distress from a cross‐cultural perspective. The study included 1,840 Japanese and 1,135 Finnish 8th grade students. The self‐reported questionnaire included the Body Image and Eating Distress Scale and Strengths and Difficulties Questionnaire (SDQ). The female adolescents from both Finland and Japan reported much greater dissatisfaction with, and concern about, their bodies than the males and Japanese females expressed even higher distress than Finnish females. High levels of body image and eating distress were associated with psychiatric problems measured with the SDQ. There was a significant three‐way interaction effect of body image and eating distress, gender and country with SDQ peer problems and prosocial behavior.     

The Rights of Future Persons under Attack: Correlativity in the Non-Identity Problem

Philosophia - This paper aims at answering some of the objections to the NIP’s criticism of the idea of rights of future persons. Those objections usually adopt different perspectives...     

Creativity in Its Social Context: The Interplay of Organizational Norms,Situational Threat,and Gender

Past research has frequently made the assumptions that creativity is an individual, rather than social, behavior; that the factors shaping creative behavior influence everyone in the same way; and that these factors always have the same influence regardless of the situation. This research challenges all 3 of these assumptions. In an experiment, participants (n = 187) assumed the role of members of a business organization with either individualist or collectivist norms that was either under competitive threat or not. Results indicated that, when threat was absent, men exhibited more divergent thinking under individualist than collectivist norms. However, the reverse was true for women when threat was absent and for both sexes when their organization was under threat. Thus, a group norm emphasizing individuality can sometimes enhance divergent thinking performance. However, this influence is moderated by other situational factors such as competitive threat, and, possibly for reasons of differing socialization, does not appear to affect men and women equally.     

The Future of the Christian Past: Marcel Gauchet and Charles Taylor on the Essence of Religion and its Evolution

This article explores the differences between Marcel Gauchet and Charles Taylor with respect to their theories of secularization. It starts by looking at their resemblances; it continues by distinguishing a two‐fold difference in their approach. The variation within their similar methodologies is examined, and then the consequences of these divergent definitions of religion are investigated. We focus on four themes: the role of the Axial religions, the significance of Incarnation and Reformation, the significance of Christianity as the ‘religion of the departure from religion’, and the possibility of religious ‘conversion’. Taylor's and Gauchet's views on the future of religion diverge as a function of their different interpretations of ‘fulfilment’ and ‘hunger for meaning’.     

The anaphase promoting complex is required for memory function in mice

Learning and memory processes critically involve the orchestrated regulation of de novo protein synthesis. On the other hand it has become clear that regulated protein degradation also plays a major role in neuronal plasticity and learning behavior. One of the key pathways mediating protein degradation is proteosomal protein destruction. The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that targets proteins for proteosomal degradation by the 26S proteasome. While the APC/C is essential for cell cycle progression it is also expressed in postmitotic neurons where it has been implicated with axonal outgrowth and neuronal survival. In this study we addressed the role of APC/C in learning and memory function by generating mice that lack the essential subunit APC2 from excitatory neurons of the adult forebrain. Those animals are viable but exhibit a severe impairment in the ability to extinct fear memories, a process critical for the treatment of anxiety diseases such as phobia or post-traumatic stress disorder. Since deregulated protein degradation and APC/C activity has been implicated with neurodegeneration we also analyzed the effect of Apc2 deletion in a mouse model for Alzheimer's disease. In our experimental setting loss of APC2 form principle forebrain neurons did not affect the course of pathology in an Alzheimer's disease mouse model. In conclusion, our data provides genetic evidence that APC/C activity in the adult forebrain is required for cognitive function.