Perceptions of the Concept of Mutation among Family Members of Patients Receiving Outpatient Genetic Services and University Students

Our objectives were to investigate: (1) relationships between perceptions of various terms regarding mutation and the depth of knowledge regarding mutation among family members of patients receiving genetic outpatient services, and (2) differences in perceptions of the term “gene mutation” for family members versus university students. Fifty-eight family members and 178 university students responded to two questionnaires: Impressions regarding the term, and Knowledge about the concept of mutation. Factor analyses were conducted to determine the factor structure of ratings of the terms, and two-way analyses of variance [(1)Term, (2)Group × Knowledge] were conducted to examine differences in perceptions of the terms as measured by scores for each extracted factor. Family members had a significantly more negative perception of the term “gene mutation” than “gene change” and a less negative perception of the term “gene mutation” than “gene lesion”; they had significantly more negative perceptions of the term “gene mutation” than did university students.     

Genetic and Environmental Influences on Personal and Rhythmic‐Motor‐Activity Tempo in Children: A Twin Study

In this study, we investigated the degree to which genetics and environmental factors influence the tempo and tempo stability of rhythmic motor activity in young children, using a twin study design. A total of 116 twin children, aged 4 years, were asked to strike two small clash cymbals together in a cyclical manner, in three phases. In the first phase, children were asked to maintain a comfortable personal tempo of rhythmic motor activity (spontaneous motor phase). In contrast, in the other phases, children were required to synchronize rhythmic motor activity in response to the timing of a stimulus tone, or a memorized tempo. Large additive genetic, although negligible shared environmental influences, were observed in the spontaneous motor phase. However, environmental factors were estimated in the other two phases, while the additive genetic factor was nearly zero. These results indicate that the extent of genetic and environmental influences on individual differences in rhythmic motor activity can be modulated under different situations.     

Age differences in the effect of physical activity on depressive symptoms

This study examined associations between physical activity and depressive symptoms in 1,151 community-dwelling adults in Japan. Physical activity was measured using a pedometer, whereas depressive symptoms were assessed with the Center for Epidemiological Studies-Depression Scale. A structural equation modeling with a cross-lagged panel design revealed that for the older adults (65-79 years of age), daily walking at baseline predicted fewer depressive symptoms at the 2-year follow-up, even after adjusting for confounders. In contrast, the association was not confirmed for the middle-aged adults (40-64 years of age). Findings suggest that age should be considered when estimating the effect of physical activity on psychological well-being.     

Interference effects between saccadic and key-press reaction times of volleyball players and nonathletes

To investigate the interference effect in volleyball players and nonathletes (ns=10) when they executed both saccadic and key-press reaction time (RT) tasks concurrently, the two groups responded to the onset of peripheral visual stimuli as quickly as possible in single and dual conditions. In the single condition, subjects responded with either saccadic eye or key-press movement. In the dual condition, they responded concurrently with both saccadic eye and key-press movements. In both groups, the key-press RT was longer in the dual condition than in the single condition. However, the amount of key-press RT delay was remarkably smaller for the volleyball players than for nonathletes. This suggests the motor command to initiate manual movement of volleyball players might be less interfered with by a concurrent oculomotor command to initiate saccadic eye movement when compared to that of nonathletes.     

Preliminary study of reminiscence therapy on depression and self-esteem in cancer patients

The present study investigated use of life review, a form of reminiscence, on the depression and self-esteem in cancer patients. 15 cancer patients in the experimental group participated in individual reminiscence therapy. 21 patients in the comparison group received no therapy. All patients were measured on both depression and self-esteem scales during two testing periods. Analysis showed mean depression scores of the cancer patients decreased and mean self-esteem increased significandy after the life-review therapy sessions, while the scores of the comparison group did not change. Furthermore, patients' psychological states were improved, and they thought their problems had been addressed. These results suggest reminiscence therapy can be useful for cancer patients.     

Hyperactivity/inattention problems moderate environmental but not genetic mediation between negative parenting and conduct problems

This study investigated the association between negative parenting (NP) and conduct problems (CP) in 6-year-old twins, taking into account the severity of hyperactivity/inattention problems (HIAP). Analyses of the data from 1,677 pairs of twins and their parents revealed that the shared environmental covariance between NP and CP was moderated by the level of HIAP but not by CP or NP, where the shared environmental covariance was larger in children with higher levels of HIAP than in children with lower levels of HIAP. The genetic covariance between NP and CP was not moderated by the level of HIAP, whereas it was larger in the group with lower levels of CP and NP than in the group with higher levels. These results suggest that severe HIAP strengthens shared environmental associations between NP and CP and that interventions focusing on the shared environmental component of NP would be effective for parents and children with severe HIAP.     

Does high educational level protect against intellectual decline in older adults?: A 10‐year longitudinal study

This study examined the relation between educational level and intellectual change in Japanese older adults. Participants (age = 65–79 years, n = 593) comprised the first‐wave participants of the National Institute for Longevity Sciences‐Longitudinal Study of Aging (NILS‐LSA). They were followed for 10 years and were tested six times. Educational levels were divided into two groups (low‐educated or high‐educated), and intellectual changes for the 10 years were assessed using the Japanese Wechsler Adult Intelligence Scale‐Revised Short Forms (JWAIS‐R‐SF); subtests included Information, Similarities, Picture Completion, and Digit Symbol. General linear mixed‐model analyses revealed that education had not affected 10‐year changes of the Information, Similarities, and Picture Completion subtest scores. In contrast, education was significantly associated with a change in the Digit Symbol subtest score; individuals with higher levels of education showed greater decline than those with less education, although they had higher ability at every time point. These findings suggest that higher education does not protect against intellectual decline in late life, although it is associated with long‐term individual differences in intelligence.     

Genetic and Environmental Influences on the Development and Stability of Executive Functions in Children of Preschool Age: A Longitudinal Study of Japanese Twins

Executive functions (EF) are an important predictor of later adaptive development. A number of environmental influences, such as parenting, have been suggested as important promoters of EF development. However, behavioural genetic research has demonstrated that many environmental influences could be affected by genetic influences. Therefore, it is important to consider genetic variations when investigating environmental influences on EF development in children. To date, few studies have used genetically informative designs to assess the etiology of EF development during the preschool years, a period of rapid development. As a result, it remains unclear how and to what extent the environmental influences that are not confounded by genetic influences affect EF development during this developmental period. The present study explored EF development during the preschool years using a longitudinal and genetically informative design and a non‐Western population. Japanese twins were visited at their homes and individually tested on EF measures at 24, 36, and 48 months of age. Phenotypic correlations and confirmatory factor analyses suggested that EF are less cohesive at 24 months of age and emerge as a common single factor at 36 and 48 months. Additionally, longitudinal and multivariate behavioural genetic analyses indicated that the EF developmental change during this period is promoted by both shared and nonshared environmental influences as well as genetic influences, while EF stability is brought about by shared environments. The present findings elucidated the etiology of EF development during the preschool years and confirmed that this period is an important transitional stage for EF development. Copyright © 2016 John Wiley & Sons, Ltd.     

Eye movement during facial affect recognition by patients with schizophrenia, using Japanese pictures of facial affect

A possible relationship between recognition of facial affect and aberrant eye movement was examined in patients with schizophrenia. A Japanese version of standard pictures of facial affect was prepared. These pictures of basic emotions (surprise, anger, happiness, disgust, fear, sadness) were shown to 19 schizophrenic patients and 20 healthy controls who identified emotions while their eye movements were measured. The proportion of correct identifications of 'disgust' was significantly lower for schizophrenic patients, their eye fixation time was significantly longer for all pictures of facial affect, and their eye movement speed was slower for some facial affects (surprise, fear, and sadness). One index, eye fixation time for "happiness," showed a significant difference between the high- and low-dosage antipsychotic drug groups. Some expected facial affect recognition disorder was seen in schizophrenic patients responding to the Japanese version of affect pictures, but there was no correlation between facial affect recognition disorder and aberrant eye movement.     

Depression in the early postpartum period and attachment to children—in mothers of NICU infants

Depression in early puerperium was evaluated in terms of maternal attachment in mothers of children admitted to the neonatal intensive care unit (NICU) in comparison to a control group of mothers of full‐term infants. A survey including Zung's self‐rating depression scale (ZSDS), a postpartum maternal attachment scale and items addressing the mother's feelings and peripheral conditions was conducted on mothers of children admitted to the NICU. Among the 153 mothers who gave valid responses, positive ZSDS scores of over 40 were seen in 61.8%. In terms of the children's disorder, strong depressive tendency was noted among mothers of low birth weight infants. Significant correlation was noted between the ZSDS and the ‘core maternal attachment’ (negative correlation) and ‘anxiety regarding children’ (positive correlation) subscales of postpartum maternal attachment. Path analysis revealed the father's positive reaction in learning of the pregnancy resulted in elevation of the ‘core maternal attachment’ score, in contrast to the control group mothers. Copyright © 2003 John Wiley & Sons, Ltd.