Angiotensin-(1-7)/Mas axis integrity is required for the expression of object recognition memory

It has been shown that the brain has its own intrinsic renin-angiotensin system (RAS) and angiotensin-(1-7) (Ang-(1-7)) is particularly interesting, because it appears to counterbalance most of the Ang II effects. Ang-(1-7) exerts its biological function through activation of the G-protein-coupled receptor Mas. Interestingly, hippocampus is one of the regions with higher expression of Mas. However, the role of Ang-(1-7)/Mas axis in hippocampus-dependent memories is still poorly understood. Here we demonstrated that Mas ablation, as well as the blockade of Mas in the CA1-hippocampus, impaired object recognition memory (ORM). We also demonstrated that the blockade of Ang II receptors AT1, but not AT2, recovers ORM impairment of Mas-deficient mice. Considering that high concentrations of Ang-(1-7) may activate AT1 receptors, nonspecifically, we evaluate the levels of Ang-(1-7) and its main precursors Ang I and Ang II in the hippocampus of Mas-deficient mice. The Ang I and Ang II levels are unaltered in the whole hipocampus of MasKo. However, Ang-(1-7) concentration is increased in the whole hippocampus of MasKo mice, as well as in the CA1 area. Taken together, our findings suggest that the functionality of the Ang-(1-7)/Mas axis is essential for normal ORM processing.     

Time-dependent effects of treadmill exercise on aversive memory and cyclooxygenase pathway function

Exercise induces brain function adaptations and improves learning and memory; however the time window of exercise effects has been poorly investigated. Studies demonstrate an important role for cyclooxygenase-2 (COX-2) pathway function in the mechanisms underlying memory formation. The aim of present work was to investigate the effects of treadmill exercise on aversive memory and COX-2, PGE(2) and E-prostanoid receptors contents in the rat hippocampus at different time points after exercise has ended. Adult male Wistar rats were assigned to non-exercised (sedentary) and exercised (running daily for 20min, for 2weeks) groups. The inhibitory avoidance task was used to assess aversive memory and the COX-2, PGE(2) and E-prostanoid receptors (EP1, EP2, EP3 and EP4) levels were determined 1h, 18h, 3days or 7days after the last training session of treadmill exercise. The step down latency in the inhibitory avoidance, COX-2 and EP4 receptors levels were acutely increased by exercise, with a significant positive correlation between aversive memory performance and COX-2 levels. Increased EP2 content decreased PGE(2) levels were observed 7days after the last running session. The treadmill exercise protocol facilitates inhibitory avoidance memory and induces time-dependent changes on COX-2 pathways function (COX-2, PGE(2) and EP receptors).     

Perceived control and anxiety in Portuguese children

The central role of perceived control in the development of anxiety disorders is proposed by several theoretical models. The main objective of the present study was to examine the relation between perceived control and anxiety in Portuguese school-age children. To accomplish this objective we developed the Portuguese short form of the Anxiety Control Questionnaire for Children (ACQ-C, Weems, 2005; Pereira & Barros, 2010), whose psychometric studies are presented. The sample comprised 238 children, aged 8 to 15 years, from the general population attending Portuguese schools. Children completed measures of perceived control (ACQ-C) and their anxiety (Screen for Child Anxiety Related Emotional Disorders--Revised, SCARED-R). The psychometric studies indicate good psychometric characteristics of the Portuguese ACQ-C short form, in particular a high internal consistency (a = .85) and an adequate temporal stability (r = .60, p = .002). Results show a significant negative association between perceived control and anxiety symptomatology, providing partial support for models that assign a central role to control beliefs in explaining the development of anxiety disorders. These results also suggest the importance of considering the perception of control as a prime target for preventive actions and intervention aimed at reducing anxiety in school aged children.     

Affiliative stimuli as primers to prosocial predispositions

Affiliative stimuli are pleasant and highly biologically relevant. Affiliative cues are thought to elicit a prosocial predisposition. Here affiliative and neutral pictures were exposed prior to a reaction time task which consisted in responding to a visual target. Half the participants responded with finger-flexion, a movement frequently involved in prosocial activities. The other half responded with finger extension, a less prosocially compatible movement. Results showed that under the exposure to affiliative pictures, as compared to neutral ones, participants who used finger flexion were faster, while those using finger extension were slower. Performance benefits to the task, when flexing the finger, together with performance costs, when extending it, indicate the relevance of movement compatibility to the context. These findings put forward a possible link between affiliative primers and motor preparation to facilitate a repertoire of movements related to prosocial predispositions including finger flexion.     

Untangling the Relationship Between Income and Subjective Well-Being: The Role of Perceived Income Adequacy and Borrowing Constraints

This paper aims to untangle the relationship between income and subjective well-being. To accomplish this, we investigate how subjective well-being is affected by two financially-related determinants that have not been investigated before or scarcely so. Specifically, we research the impact on subjective well-being of how people are coping with their present income as well as of their borrowing constraints. The results indicate that both variables determine subjective well-being and that they mediate the effects of other variables, namely income, which is not directly related to well-being. Additionally, they signal that income matters to the extent to which it contributes to meeting the desired consumption needs and eases borrowing constraints. Such mediating effects thus contribute to explain how income affects subjective well-being. We also inspect differences in life satisfaction responsiveness to perceived income adequacy and borrowing constraints in certain groups of individuals, and find that the subjective well-being of individuals in a more fragile financial position is particularly responsive to the alleviation of borrowing constraints.     

Psychoanalysis and Epistemology: The Interrelation Between Clinical Work,Culture and Metapsychology

The paradigmatic theory of modern epistemology holds psychoanalysis in its scientific statute. Even if there is no explicit epistemology in the Freudian writings, it is undeniable that the genesis of psychoanalysis has a rigorous dialetic between theorization and clinical observation. Metapsychology is an organized and consistent set of concepts, capable of explaining and coordinating the analytical experience. It is through metapsychology that clinical work encounters the possibility of universalization, while metapsychology finds the possibility of fulfillment in clinical work. Clinical experience also confirms the interrelation between psychopathology and culture. Modern times have brought about new versions for psychopathological symptoms, which, in turn, have special effects on the narcisistic personalities and the manifestations of anxiety, giving place to different neurotic configurations.     

Contemporary Adolescence and the Crisis of Ideals

The end of the 20th century inaugurates the tele-techno-media dimension that gives place to subjective mutation of incalculable effects. These transformations crucially affect adolescents and youths, for this new dimension promotes a planetary enlargement of the non-family influences which act directly on idealness. Held between the illusionary temptation of the ideal-ego and the possibility of living the ego ideal, the adolescent suffers through the confrontation with this colossal identifying, fragmented and voracious mirror. The author then discusses what the psychoanalyst can do.     

Three ways of understanding Ida

This paper aims to compare the psychoanalytic understanding of three analysts, sharing a similar theoretical background, with regard to the clinical material of an autistic girl with probable organic impairment. The conclusion is that, although the three analysts' ideas about the pathogenesis of the girl's developmental disorder are somewhat divergent, a tendency towards convergence can be noted as the therapy goes on. The paper concludes that there is some common ground of understanding about autistic phenomena among psychoanalysts sharing the same affiliation, that combining the individual views of different analysts may enlarge the understanding of the case as a whole and that the technique Tustin used to treat psychogenic autistic children can also be used to treat brain-damaged autistic children.