The role of cortical cholinergic pre- and post-synaptic receptors in taste memory formation

A number of studies have implicated cholinergic activity in the mediation of learning and memory processes. However, the specific role of muscarinic receptors in memory formation mechanisms is less known. The aim of the present study is to evaluate the effects of muscarinic antagonist M2 presynaptic receptor, AFDX-116 (0.5mM) and M1 and M3 post-synaptic receptor pirenzepine (100mM), as well as a non-selective muscarinic antagonist, scopolamine (136mM), in the insular cortex (IC) during acquisition and retrieval of conditioned taste aversion (CTA). In addition, we evaluate the effects of those antagonists in cortical ACh release by in vivo microdialysis and the effects on the induction of in vivo LTP in the BLA-IC projection. The results showed that the cortical microinjections of scopolamine and pirenzepine, but not AFDX-116, produced significant disruption in the acquisition of CTA, without effects during retrieval. Microinjections of scopolamine and AFDX-116 produced significant cortical ACh release, while infusions of pirenzepine did not produce any release. Application of scopolamine and pirenzepine diminished induction of LTP in the BLA-IC projection, but not AFDX-116, as compared with vehicle. The induction of BLA-CI LTP seems to be modulated by post-synaptic muscarinic acetylcholine receptors and not by pre-synaptic muscarinic receptors. These results suggest a differential involvement of cholinergic receptors during acquisition and retrieval of aversive memory formation, as well as a differential role of muscarinic receptors in the biochemical and electrophysiological processes that may underlay aversive memory.     

Flexible conceptual projection of time onto spatial frames of reference

Flexibility in conceptual projection constitutes one of the most challenging issues in the embodiment and conceptual metaphor literatures. We sketch a theoretical proposal that places the burden of the explanation on attentional dynamics in interaction with mental models in working memory that are constrained to be maximally coherent. A test of this theory is provided in the context of the conceptual projection of time onto the domain of space. Participants categorized words presented at different spatial locations (back–front, left–right) as referring to the past or to the future. Responses were faster when the irrelevant word location was congruent with the back–past, front–future metaphoric mapping. Moreover, when a new highly task-relevant spatial frame of reference was introduced, it changed the projection of past and future onto space in a way that was congruent with the new frame (past was now projected to left space and future to right space), as predicted by the theory. This study shows that there is substantial flexibility in conceptual projection and opens a venue to study metaphoric variation across tasks, individuals, and cultures as the result of attentional dynamics.     

Estrogen modulates place learning through estrogen receptors in the hippocampus

Moderate elevations in circulating estradiol enhance learning in tasks that tap place learning strategies such as those requiring the use of extramaze cues. Use of place learning strategies is particularly impaired by damage to the hippocampus, a structure shown to be sensitive to estrogen treatments. We have shown that direct estrogen infusions into the dorsal hippocampus, and not the dorsolateral striatum, enhance place learning, suggesting that the hippocampus may be an important modulatory site for the effects of estrogen on place learning. The current experiment tested whether the hippocampus is indeed a critical site of estrogen modulation through classical estrogen receptors. Young adult female Sprague-Dawley rats were ovariectomized for 21 days and given systemic injections (0.1 ml) of sesame oil (OIL) or 10 microg of 17beta-estradiol-benzoate (E2), 48 and 24 h before being trained on a place task. Twenty-four hours prior to the first systemic injection, separate groups of rats received bilateral hippocampal implants of either the antiestrogen ICI 182,780 (ICI) or cholesterol vehicle. Implants were maintained until and throughout training. Intrahippocampal ICI reversed the enhancement in place learning seen with systemic E2 treatment. Unexpectedly, intrahippocampal ICI in OIL-treated rats also enhanced place learning. These data suggest that ICI may have some mixed agonist and antagonist effects in the hippocampus and that estrogen enhances place learning through activation of estrogen receptors located in the hippocampus.     

Differential age effects on attention-based inhibition: inhibitory tagging and inhibition of return

The purpose of this study was to determine whether 2 forms of attentional inhibition, inhibition of return (IOR) and inhibitory tagging, are differentially affected by the aging process. The authors tested 24 younger adults (mean age = 22 years) and 24 older adults (mean age = 69 years) on a combined IOR and Stroop task (Vivas & Fuentes, 2001). As predicted, younger adults' performance was consistent with inhibitory tagging of objects at inhibited locations. Although older adults demonstrated intact IOR, there was no evidence of inhibitory tagging. The results suggest that age deficits in inhibition are selective.     

Self-talk and affective problems in college students: valence of thinking and cognitive content specificity

The aim of this study was to develop a Self-Talk Inventory for young adults. This inventory consisted of two scales. The Negative Self-Talk Scale included three categories of self-talk (depressive, anxious, and angry thoughts) and the Positive Self-Talk Scale, three categories (minimization, positive orientation, and coping self-instructions). Participants were 982 undergraduate students (Mean age = 20.35 years, SD = 2.16). They completed the self-talk scales together with the following scales to measure symptoms of affective disorders: the Center for Epidemiological Studies Depression Scale (CES-D), the State-Trait Anxiety Inventory (STAI), and the State-Trait Anger Expression Inventory (STAXI-T). Factor analyses confirmed the hypothesized structure for the Self-Talk Inventory. The relations between self-talk and symptoms of affective disorders (depression, anxiety, and anger) were also evaluated. In general, states-of-mind -SOM- ratios and negative cognitions showed a greater association with psychological symptoms than did positive cognitions. Results concerning the cognitive characteristics of depression, anxiety, and anger were mixed and partially supported the cognitive content specificity theory.     

Feelings or cognitions? Moral cognitions and emotions as longitudinal predictors of prosocial and aggressive behaviors

There is debate regarding the roles of sociomoral cognitions and emotions in understanding moral development. The short-term longitudinal relations among perspective taking, sympathy, prosocial moral reasoning, prosocial behaviors and aggression in adolescents were examined. Participants were 489 students (M age = 12.28 years, SD = .48; 232 boys) in public and private schools from predominantly middle class families in Valencia, Spain. Students completed measures of perspective taking, sympathy, prosocial moral reasoning, prosocial behaviors, and aggressive behaviors. Overall, structural equation modeling analyses showed that moral reasoning and emotions were interrelated and predicted both prosocial behaviors and aggression. Discussion focuses on the relevance of both social cognitions and emotions in moral development.     

Re-examining the contribution of visuospatial working memory to inhibition of return

Castel and colleagues (Percept Psychophys 65(6):970–981, 2003) proposed that visuospatial working memory is needed to retain and update the irrelevant but attended location in an inhibition of return (IOR) procedure. In a series of three experiments, we re-examined this hypothesis by loading visuospatial working memory and manipulating the timing of encoding. When the visuospatial memory items were presented right after the cue, as in Castel et al. (Percept Psychophys 65(6):970–981, 2003), we replicated the lack of IOR in the dual-task condition (Experiment 1). However, when we presented the visuospatial memory items before the spatial cue, to control for retroactive interference in encoding, we found robust IOR effects (Experiment 2); the effect remained strong even when participants were prevented from using verbal labels to rehearse the memory material (Experiment 3). We conclude that IOR does not seem to depend on retaining the position of the irrelevant cue in visuospatial working memory.     

Portfolio Selection from Multiple Benchmarks: A Goal Programming Approach to an Actual Case

This paper deals with benchmark‐based portfolio choice for buy‐and‐hold strategies of investing. Multiple benchmarks for returns are considered, which is more realistic than taking a unique benchmark – a unique aspiration difficult to select in practice among the various aspirations for returns that the investor has in mind. Portfolio selection with multiple benchmarks leads to a multi‐objective problem, which is addressed by mean value – stochastic goal programming. In particular, two benchmarks are considered, which involves two goals. Weights for goals depend on investor's preferences and Arrow's absolute risk aversion coefficients. An efficient frontier of portfolios is obtained. Advantages of this stochastic method in our context are as follows: (i) Mean value‐stochastic goal programming relies on classical utility theory under uncertainty and Arrow's absolute risk aversion, which ensures soundness and strictness, and (ii) the numerical model is easily solved by using available software such as mean–variance software. Numerical results are tabulated and discussed. Copyright © 2011 John Wiley & Sons, Ltd.     

Work-family balance and energy: A day-level study on recovery conditions

The present study examines whether daily recovery inhibiting and enhancing conditions predict day-levels of work-family conflict (WFC), work-family facilitation (WFF), exhaustion and vigor. Forty-nine individuals from various professional backgrounds in Spain provided questionnaire and daily survey measures over a period of five working days. Multilevel analyses showed that day-levels of work pressure and recovery after breaks at work significantly predicted WFC and exhaustion, and WFF and vigor, respectively. Moreover, daily fluctuations in expression of emotions had different effects depending on the expressed content (negative or positive) and the setting where it took place (work or home). Furthermore, additional analyses provided some evidence for a moderating role of expression of emotions at work on the relationship between recovery inhibiting and enhancing conditions and exhaustion. These findings reveal practical implications for individuals and organizations and suggest possible avenues for future research.     

Illegitimacy improves goal pursuit in powerless individuals

The effects of power legitimacy on self-regulation during goal pursuit were examined. Study 1 focused on goal-setting and goal-striving. Specifically, it examined how much time legitimate and illegitimate powerless individuals needed to set goals, and how many means they generated to pursue these goals. Study 2 examined persistence in the face of difficulties. Consistently across these studies illegitimacy improved self-regulation in powerless individuals. Illegitimate powerless individuals behaved similarly as control participants. They took less time to decide on a course of action, used more flexible means to strive for goals, and persisted longer in the face of difficulties, compared to their legitimate counterparts. The implications of these findings are discussed.