Looking for Trouble: Preventive Genomic Sequencing in the General Population and the Role of Patient Choice

Advances in genomics have led to calls for developing population-based preventive genomic sequencing (PGS) programs with the goal of identifying genetic health risks in adults without known risk factors. One critical issue for minimizing the harms and maximizing the benefits of PGS is determining the kind and degree of control individuals should have over the generation, use, and handling of their genomic information. In this article we examine whether PGS programs should offer individuals the opportunity to selectively opt out of the sequencing or analysis of specific genomic conditions (the menu approach) or whether PGS should be implemented using an all-or-nothing panel approach. We conclude that any responsible scale-up of PGS will require a menu approach that may seem impractical to some, but that draws its justification from a rich mix of normative, legal, and practical considerations.     

Relationships Between Physical Symptoms,Emotional Distress,and Pain Appraisal in Fibromyalgia: The Moderator Effect of Alexithymia

Alexithymia is a personality construct that is frequently identified in fibromyalgia (FM). Previous studies have explored the relationship between alexithymia and emotional distress in this disease. Yet, the additional link with factors of pain appraisal is unknown. This study examined the moderating effect of alexithymia in the relationship between emotional distress and pain appraisal in 97 FM women. A control group of 100 healthy women also participated in the study. All participants completed several self-reports about pain experience, sleep quality, impairment, emotional distress, pain appraisal, and alexithymia. FM women showed significantly more difficulty in identifying and describing feelings, but less externally oriented thinking than healthy women. In the clinical group, difficulty in identifying feelings and difficulty in describing feelings significantly correlated with lower sleep quality, higher anxiety and depression, and increased pain catastrophizing and fear of pain. Difficulty in describing feelings significantly correlated with higher pain experience and vigilance to pain. Externally oriented thinking was not correlated with any of the clinical variables. Difficulty in identifying feelings moderated the relationship between anxiety and pain catastrophizing, and difficulty in describing feelings moderated the relationship between anxiety and fear of pain. Implications of the findings for the optimization of care of FM patients are discussed.     

Overlap in Facebook Profiles Reflects Relationship Closeness

We assessed the association between self-reported Inclusion of Other in the Self (IOS) and Facebook overlap. Ninety-two participants completed online measures of IOS and investment model constructs. Researchers then recorded Facebook data from participants’ profile pages. Results from multilevel models revealed that IOS predicted Facebook overlap. Furthermore, Facebook overlap was associated with commitment and investment in ways comparable to self-reported IOS. These findings suggest that overlap in Facebook profiles can be used to measure relationship closeness.     

COMT and DAT1 polymorphisms moderate the indirect effect of parenting behavior on youth ADHD symptoms through neurocognitive functioning

Although gene × environment interactions contribute to youth attention-deficit/hyperactivity disorder (ADHD) symptoms, the pathways mediating these influences are unknown. We tested genetic moderation of indirect effects from parenting behavior to youth ADHD symptoms through multiple neurocognitive factors. Two hundred and twenty-nine youth with and without ADHD were assessed at baseline (Wave 1; ages 5–10) and at a 2-year follow-up (Wave 2; ages 7–13). At Wave 1, youth completed a neurocognitive battery including measures of response inhibition, visuospatial working memory, and fluid reasoning, and a standardized parent–child interaction task yielding observational measures of positive and negative parenting. At Wave 2, youth psychopathology was rated by parents and teachers using multiple methods (i.e., structured interview, rating scale). We employed moderated multiple mediation and compared conditional indirect effects across youth genotypes at two biologically plausible genetic loci. Controlling for parent ADHD symptoms as well as youth demographic factors and co-occurring externalizing symptoms, these genetic factors moderated the indirect effect from Wave 1 parenting to multi-method/informant Wave 2 ADHD symptoms through Wave 1 neurocognitive functioning. This preliminary study is the first to identify genetic moderation of mediated effects underlying ADHD symptoms and suggests that specific gene × parenting interactions may underlie neurocognitive functioning deficits and subsequent ADHD.     

Making Sense of Non-refuting Anomalies

As emphasized by Larry Laudan in developing the notion of non-refuting anomalies (Laudan 1977; Nola and Sankey 2000), traditional analyses of empirical adequacy have not paid enough attention to the fact that the latter does not only depend on a theory’s empirical consequences being true but also on them corresponding to the most salient phenomena in its domain of application. The purpose of this paper is to elucidate the notion of non-refuting anomaly. To this end, I critically examine Laudan’s account and provide a criterion to determine when a non-refuting anomaly can be ascribed to the applicative domain of a theory. Unless this latter issue is clarified, no proper sense can be made of non-refuting anomalies, and no argument could be opposed to those cases where an arbitrary restriction in a theory’s domain of application dramatically reduces the possibilities for its empirical scrutiny. In arguing for the importance of this notion, I show how several semanticist resources can help to reveal its crucial implications, not only for theory evaluation, but also for understanding the nature of a theory’s applicative domain.     

Experiencing the mastership in transdisciplinary studies for sustainability

In this article, we describe the transdisciplinarity process in our education postgraduate program at the University of Veracruz. The program emphasizes the main processes of the eco-formation experience for sustainability through a transdisciplinarity methodology that is focused on three processes: (a) Re-Learning; (b) Eco-literacy; and (c) Dialogue of Knowledge. The experience of self-knowledge is described through our specific re-learning practices in the Mastership program, which represents a central tenet in the process for creating our Learning Community through holarchy practices, profound dialogues, and self-organization processes. Finally we discuss three central ideas: creativity, spirituality, and play, which express and nurture our Learning Community.     

Effects of lifestyles and the Mediterranean diet on elderly people’s quality of life according to gender / Efectos de los estilos de vida y la dieta mediterránea en la calidad de vida en personas mayores en función del género

Abstract

Health-related quality of life (HRQoL) has been associated with certain eating habits, such as the Mediterranean diet (MD) and lifestyles. However, the specific role of gender in this association is not yet known. The objective of this study was to analyse the relationship between the consumption of the MD essential foods and lifestyle (tobacco and alcohol consumption and exercise) with the HRQoL of 340 elderly people aged over 60 living in the Spanish Mediterranean area. The results show a better HRQoL in males. Compared to females, the lifestyles of males include a moderate consumption of alcohol and tobacco in addition to a greater frequency of physical activity. The predictive models of HRQoL were also different between males and females, as the influence of lifestyles and MD were greater in males. These results are clinically useful for the designing of programmes that promote successful ageing as they can be specified for sex.     

Autism: Hard to Switch from Details to the Whole

It has long been proposed that individuals with autism exhibit a superior processing of details at the expense of an impaired global processing. This theory has received some empirical support, but results are mixed. In this research we have studied local and global processing in ASD and Typically Developing children, with an adaptation of the Navon task, designed to measure congruency effects between local and global stimuli and switching cost between local and global tasks. ASD children showed preserved global processing; however, compared to Typically Developing children, they exhibited more facilitation from congruent local stimuli when they performed the global task. In addition, children with ASD had more switching cost than Typically Developing children only when they switched from the local to the global task, reflecting a specific difficulty to disengage from local stimuli. Together, results suggest that ASD is characterized by a tendency to process local details, they benefit from the processing of local stimuli at the expense of increasing cost to disengage from local stimuli when global processing is needed. Thus, this work demonstrates experimentally the advantages and disadvantages of the increased local processing in children with ASD.     

Children’s Maternal Representations Moderate the Efficacy of Parent–Child Interaction Therapy—Emotion Development (PCIT-ED) Treatment For Preschool Depression

Research on Child and Adolescent Psychopathology - A randomized controlled trial (RCT) demonstrated that a novel psychotherapy, Parent–Child Interaction Therapy—Emotion Development...     

Integrative review on career interventions with unemployed people: Nature,outcomes, and recommendations

The study of career development among unemployed people is vital for effective institutional responses. This integrative review based on Torraco's protocol fills a literature gap by synthesizing research on interventions for this population. Seven keywords, five databases, and six eligibility criteria were defined. Among 324 articles, 36 were reviewed. Findings highlight diverse counseling modalities, emphasizing group interventions and remote delivery. Tailored approaches, including length, frequency, and social-emotional and career dimensions, are crucial. Practical recommendations emphasize comprehensive, psychological support, goal-oriented counseling, and postintervention assistance. These insights underscore vocational psychology's importance in addressing unemployment, impacting government policies, career services, and psychologists.