Complexities of Genetic Counseling for ALS: A Case of Two Siblings with Discordant Genetic Test Results

Rapid advances in the genetics of amyotrophic lateral sclerosis (ALS) have dramatically changed the approach of clinicians and researchers to the motor neuron diseases. We report two siblings in whom the genetic study provided conflicting results, hence raising a number of issues which deserve to be considered by clinicians involved in genetic testing for ALS. The first patient died within 2 years of ALS onset, while her brother still manages to walk unaided, 7 years into onset. Genetic analyses, performed on the first patient as part of a research protocol, and as clinical genetic testing on the brother, provided different results. Results for Patient 1 were negative for all investigated genes, thus suggesting that her disease may be a phenocopy, while her brother carried an autosomal dominant TARDBP mutation (p.A382T). A multidisciplinary approach may help patients and clinicians face the emerging dilemmas in such a complex field. Sharing and updating of advances, not to mention uncertainties inherent to current knowledge, with patients and families may prove to be an effective way to support them and to make them aware of the present limits of our knowledge and of the blurred border between research and clinical practice.     

Cross-Cultural Patterns of Student Victimization in Israel and Chile

School violence is a global concern that calls for international research using cross context methods. Although there are several international surveys that compare school violence across countries, they do not clearly address issues of similarities and differences in relative prevalence of different types of victimization and their relations with age, sex, and cultural group. We explored these questions among Israeli-Arab (n?=?13,606), Israeli-Jewish (n?=?10,637), and Chilean students in poor schools in a large Chilean city (n?=?4557), using the same self-report questionnaire that measures verbal-social victimization, victimization by threats, physical victimization, and sexual harassment. As hypothesized, we found similarities in the patterns of relative prevalence of victimization types, as well as study group, sex, and age main effects and interactions. These effects were evident even when the lowest third SES group in Israel was compared with the Chilean students. These findings suggest group differences in prevalence of student victimization, and at the same time cultural invariance in relative prevalence of victimization types and their relations with sex and age. We discuss the need for more international comparative research in this field that takes into account cultural values and the structure and organizations of schools within the different educational systems.     

Are There Gender Differences in Emotion Comprehension? Analysis of the Test of Emotion Comprehension

This article examines whether there are gender differences in understanding the emotions evaluated by the Test of Emotion Comprehension (TEC). The TEC provides a global index of emotion comprehension in children 3–11 years of age, which is the sum of the nine components that constitute emotion comprehension: (1) recognition of facial expressions, (2) understanding of external causes of emotions, (3) understanding of desire-based emotions, (4) understanding of belief-based emotions, (5) understanding of the influence of a reminder on present emotional states, (6) understanding of the possibility to regulate emotional states, (7) understanding of the possibility of hiding emotional states, (8) understanding of mixed emotions, and (9) understanding of moral emotions. We used the answers to the TEC given by 172 English girls and 181 boys from 3 to 8 years of age. First, the nine components into which the TEC is subdivided were analysed for differential item functioning (DIF), taking gender as the grouping variable. To evaluate DIF, the Mantel–Haenszel method and logistic regression analysis were used applying the Educational Testing Service DIF classification criteria. The results show that the TEC did not display gender DIF. Second, when absence of DIF had been corroborated, it was analysed for differences between boys and girls in the total TEC score and its components controlling for age. Our data are compatible with the hypothesis of independence between gender and level of comprehension in 8 of the 9 components of the TEC. Several hypotheses are discussed that could explain the differences found between boys and girls in the belief component. Given that the Belief component is basically a false belief task, the differences found seem to support findings in the literature indicating that girls perform better on this task     

Always look on the bright side of students: does valence of teacher perceptions relate to students’ educational performance?

Social Psychology of Education - We studied the role of the valence of female teachers’ perceptions in predicting various student outcomes. Using a prospective design, at the beginning of...     

The influence of in-group and out-group favouritism on the disciplinary practice of ethnic majority and minority preservice teachers

Social Psychology of Education - Teacher judgments and the disciplinary sanctioning of pupils can be understood as a function of the ethnic match, which means whether or not teachers and pupils...