Effects of post-trial administration of naloxone and beta-endorphin on shock-induced fighting in rats

To study the involvement of endogenous opioid peptides in the development of shock-induced fighting, naloxone (2 mg/kg) or beta-endorphin (10 micrograms/kg) was administered subcutaneously immediately after the session and during nine consecutive daily sessions to rats repeatedly exposed to electric shocks. beta-Endorphin blocked the development of shock-induced fighting while naloxone facilitated it but only when shock-induced fighting occurred at a low rate. The effects of beta-endorphin were time dependent since when beta-endorphin was injected 90 min after the shock session instead of immediately after, its impairing effect disappeared. In addition, naloxone blocked the impairment produced by beta-endorphin. Differential postsession treatment of each member of pairs of rats with naloxone and beta-endorphin resulted in a higher probability of rats treated with naloxone to be dominant over rats treated with beta-endorphin in the test situation. These results are discussed in relation with the possible involvement of endogenous opioids in the modulation of the physiological consequences of defensive behavioral responses to shock.     

Choice, experience, and the generalized matching law

Five pigeons were exposed to different pairs of concurrent variable-interval, variable-interval schedules on nine experimental conditions of 30 sessions each. For every session, the parameters of the generalized matching equation were computed for the first five, six, seven, eight, and nine experimental conditions. The exponent a, both for response and time distribution, tended to decrease with increases in number of experimental conditions and to increase with number of sessions per condition, but values of k (bias) varied unsystematically. When the subjects were exposed to five new pairs of schedules, with 55 sessions per condition, the findings were confirmed. Data from the literature on the generalized matching law suggest that the variability of exponent values may be explained in part by the use of naive or experienced subjects in different investigations and by the variability in number of experimental conditions and in number of sessions per condition.     

Mixed models,random utilities,and the triangle inequality

A new probabilistic binary choice model, which we call the mixed model is proposed. This model is used to give an interpretation of probabilistic choice behavior in terms of complete and partial orders. The model is used as a guide to disprove Jacob Marschak's conjecture that the binary random utility model is equivalent to the triangle inequality. Another result is presented concerning the relation between moderate stochastic transitivity and the triangle inequality.     

DISCRIMINATIVE CONTROL OF THERAPISTS' PERFORMANCE1

In order to examine therapists' discriminative responding to normal and idiosyncratic patient responses, naive subjects were presented with a simulated “patient” for treatment. The subjects were made to believe they were reinforcing normal verbalizations emitted by this patient In fact, they were listening to a tape on which normal and idiosyncratic verbalizations had been recorded. Different probabilities of normal and idiosyncratic “patient” verbalizations could be presented to the subjects by means of a digital programming unit. In one of a number of conditions, the subjects' accurate reinforcing responses were followed by an increased probability of the patient's normal verbalizations. Accurate reinforcing responses emitted by the subjects were brought under the control of normal and idiosyncratic patient responses, by use of contingent feedback, change in patient responding, and monetary reinforcers. When the patient's normal verbalizations increased in probability, so did the subjects' accurate reinforcing responses following the patient's normal verbalizations, and to a lesser degree, the subjects' inaccurate reinforcing responses following the patient's idiosyncratic verbalizations. When the patient's idiosyncratic verbalizations increased in probability, the subjects' accurate and inaccurate reinforcing responses decreased in probability. The clinical implications of these tendencies are discussed.     

On the failure of transfer of control from separately conducted Pavlovian conditioning to free-operant avoidance conditioning in rats

In Experiment 1, presentation of a tone previously correlated with foot shock produced an increase in the rate of rats' foot-shock avoidance responding, while presentation of a tone previously correlated with tail shock had no reliable effect on the rate of foot-shock avoidance responding. In Experiment 2, a tone correlated with tail shock elicited heart-rate conditioned responses, but had no reliable effect on the rate of subsequent foot-shock avoidance responding. In Experiment 3, presentation of a tone previously correlated with foot shock, and a tone previously correlated with tail shock in separate groups produced increases in the rate of tail-shock avoidance responding. In Experiment 4, a tone correlated with tail shock in one setting accelerated tail-shock avoidance responding in a second setting. Interaction between US and negative reinforcer modifiability by skeletal responding may contribute to the pattern of results obtained.     

Discrimination of a response-independent component in a multiple schedule

Pigeons were trained to respond in non-differential reinforcement pre-discrimination training, with a multiple variable-interval 1-min variable-interval 1-min schedule. Each bird then received discrimination training with a multiple variable-interval 1-min variable-time 1-min schedule. Thus, discrimination training was between response-dependent (variable-interval) and response-independent (variable-time) schedules with the rate of reinforcement equated. In Experiment I, only three sessions of non-differential reinforcement preceded discrimination training and for half the birds, a 0° line was correlated with the response-dependent schedule; for the remaining birds the 0° line was correlated with the response-independent schedule. Post-discrimination gradients of excitatory stimulus control were obtained from the former group, while the latter group showed little evidence of post-discrimination stimulus control by the 0° line. Differential responding to the variable-time schedule was not accompanied by behavioral contrast to the variable-interval schedule. In Experiment II, 20 sessions of non-differential reinforcement preceded discrimination training and the 0° line was correlated with variable-time reinforcement for each bird. Differential responding to the 0° line was accompanied by negative induction to the variable-interval schedule and by inhibitory stimulus control about the 0° line during a post-discrimination generalization test.     

Additive structure in qualitative data: An alternating least squares method with optimal scaling features

A method is developed to investigate the additive structure of data that (a) may be measured at the nominal, ordinal or cardinal levels, (b) may be obtained from either a discrete or continuous source, (c) may have known degrees of imprecision, or (d) may be obtained in unbalanced designs. The method also permits experimental variables to be measured at the ordinal level. It is shown that the method is convergent, and includes several previously proposed methods as special cases. Both Monte Carlo and empirical evaluations indicate that the method is robust.This research was supported in part by grant MH-10006 from the National Institute of Mental Health to the Psychometric Laboratory of the University of North Carolina. We wish to thank Thomas S. Wallsten for comments on an earlier draft of this paper. Copies of the paper and of ADDALS, a program to perform the analyses discussed herein, may be obtained from the second author.     

SKED systems: Paper tape,Tennecomp, and OS/8

The SKED system has been developed at different levels of complexity and power for differing hardware configurations. The simplest of these, and the least expensive, is the paper-tape SKED system. Some of the drawbacks associated with the use of paper tape are absent in the Tennecomp magnetic tape cartridge system. Users with mass storage capabilities can make use of the OS/8 operating system (copyright DEC) to speed up all aspects of the SKED system (especially editing, compilation, and loading of programs), and take advantage of a file-oriented system structure for data storage and analysis.