A goal activation approach to the study of executive function: an application to antisaccade tasks

We argue that a general control process, responsible for the activation and maintenance of task goals, is central to the concept of executive function. Failures of this process can become manifest as goal neglect: disregard of a task requirement even though it has been understood (Duncan, 1995). We discuss the results of several published and new experiments using various versions of the antisaccade task in order to investigate the circumstances under which goal neglect is likely to occur. Potentially conflicting results in the literature on adaptive control of saccadic eye movements are argued to be attributable to the extent to which different task versions elicit goal neglect. The results suggest an increased susceptibility to goal neglect of high-functioning older adults (Experiment 1) and of first-episode schizophrenia patients (Experiment 2), but not of patients with obsessive-compulsive disorder (Experiment 3). However, the degree to which such differences in susceptibility become manifest in task performance, is shown to be strongly influenced by manipulations of the relative saliency of task requirements. Theoretical and methodological implications for the study of executive function are discussed.     

Interactions between study task, study time, and the low-frequency hit rate advantage in recognition memory

In studies of episodic recognition memory, low-frequency words (LF) have higher hit rates (HR) and lower false alarm rates (FAR) than do high-frequency words (HF), which is known as the mirror pattern. A few findings have suggested that requiring a task at study may reduce or eliminate the LF-HR advantage without altering the LF-FAR effect. Other studies have suggested that the size of the LF-HR advantage interacts with study time. To explore such findings more thoroughly and relate them to theory, the authors conducted 5 experiments, varying study time and study task. The full mirror pattern was found only in 2 cases: the standard condition requiring study for a later memory test and a condition requiring a judgment about unusual letters. The authors explain their findings in terms of the encoding of distinctive features and discuss the implications for current theories of recognition memory and the word frequency effect.     

Verbal mediation of number knowledge: evidence from semantic dementia and corticobasal degeneration

Patients with corticobasal degeneration (CBD) appear to have impaired number knowledge. We examined the nature of their number deficit while we tested the hypothesis that comprehension of larger numbers depends in part on verbal mediation. We evaluated magnitude judgments and performance on number conservation measures rooted in Piagetian theory in nonaphasic patients with CBD (n=13) and patients with a fluent form of progressive aphasia known as semantic dementia (SD; n=15). We manipulated the numbers of the arrays and the visual-spatial properties of the stimuli being compared during magnitude judgments and Piagetian conservation measures. CBD patients were consistently impaired judging the magnitudes of larger numbers (4-9), while they had minimal difficulty with smaller numbers (magnitudes < or = 3). By comparison, SD patients performed all measures of number knowledge at a ceiling level regardless of number magnitude. Neither patient group was significantly impacted by manipulations of the spatial properties of the stimuli. CBD patients' impairment with larger numbers despite minimal aphasia, and SD patients' intact performance despite an aphasia, challenge the proposal that understanding larger numbers depends on verbal mediation.     

Visual discrimination of normal and drug induced behavior in quails (<Emphasis Type="Italic">Coturnix coturnix japonica</Emphasis>)

The ability to discriminate the physical states of others could be an adaptive behavior, especially for social animals. For example, the ability to discriminate illness behavior would be helpful for avoiding spoiled foods. We report on an experiment with Japanese quails testing whether these birds can discriminate the physical states of conspecifics. The quails were trained to discriminate between moving video images of quails injected with psychoactive drugs and those in a normal (not injected) condition. Methamphetamine (stimulant) or ketamine (anesthetic) were used to produce drug-induced behaviors in conspecifics. The former induced hyperactive behavior and the latter hypoactive behavior. The subject quails could learn the discrimination and showed generalization to novel images of the drug-induced behaviors. They did not, however, show discriminative behavior according to the type and dosage of the drugs. Thus, they categorized the behavior not on the basis of degree of activity, but on the basis of abnormality.     

A computational feature binding model of human texture perception

We present a computational model for human texture perception which assigns functional principles to the Gestalt laws of similarity and proximity. Motivated by early vision mechanisms, in the first stage, local texture features are extracted by utilizing multi-scale filtering and nonlinear spatial pooling. In the second stage, features are grouped according to the spatial feature binding model of the competitive layer model (CLM; Wersing et al. 2001). The CLM uses cooperative and competitive interactions in a recurrent network, where binding is expressed by the layer-wise coactivation of feature-representing neurons. The Gestalt law of similarity is expressed by a non-Euclidean distance measure in the abstract feature space with proximity being taken into account by a spatial component. To choose the stimulus dimensions which allow the most salient similarity-based texture segmentation, the feature similarity metrics is reduced to the directions of maximum variance. We show that our combined texture feature extraction and binding model performs segmentation in strong conformity with human perception. The examples range from classical microtextures and Brodatz textures to other classical Gestalt stimuli, which offer a new perspective on the role of texture for more abstract similarity grouping.     

Amygdala and periaqueductal gray lesions only partially attenuate unconditional defensive responses in rats exposed to a cat

Defensive responses to a cat were observed in rats given excitotoxic lesions of the central nucleus of the amygdala (ACe), dorsolateral periaqueductal gray (dlPAG), ventral periaqueductal gray (vPAG), or sham lesions. Rats were placed adjacent to a compartment containing a cat. Sham-lesioned rats avoided the area nearest the cat and preferred the area furthest away from the cat. They also exhibited numerous defensive responses including, climbing, escape from the apparatus, and freezing. Rats with lesions of the ACe reacted like the sham lesioned rats by preferring the area of the apparatus furthest from the cat, however they climbed and escaped significantly less than sham lesioned rats. Avoidance of the area adjacent to the cat was attenuated in rats with lesions of the vPAG. Climbing along the walls of the apparatus was also attenuated in rats with lesions of the vPAG. Escapes from the apparatus were not significantly reduced by lesions of the vPAG and dlPAG. Thus, ACe lesions attenuated climbing and eliminated escapes, but did not impair locomotion of the rat away from the cat.     

Differential mastication kinematics of the rabbit in response to food and water: Implications for conditioned movement

Analysis of naturalistic chewing patterns may provide insight into mapping the neural substrates of jaw movement control systems, including their adaptive modification during the classically conditioned jaw movement (CJM) paradigm. Here, New Zealand White rabbits were administered food and water stimuli orally to evaluate the influence of stimulus consistency on masticatory pattern. Chewing patterns were recorded via video camera and movements were analyzed by computerized image analysis. The mandibular kinematics, specifically the extent of dorsal/ventral, medial/lateral, and rostral/caudal movement, were significantly larger in food-evoked than water-evoked chewing. Water-evoked chewing frequency, however, was significantly higher than that of food-evoked movements. In light of known cortical mastication modulatory centers, our findings implicate different neural substrates for the responses to food and water stimuli in the rabbit. A detailed delineation of jaw movement patterns and circuitry is essential to characterize the neural substrates of CJM.