Selective inactivation of adenosine A(2A) receptors in striatal neurons enhances working memory and reversal learning

The adenosine A(2A) receptor (A(2A)R) is highly enriched in the striatum where it is uniquely positioned to integrate dopaminergic, glutamatergic, and other signals to modulate cognition. Although previous studies support the hypothesis that A(2A)R inactivation can be pro-cognitive, analyses of A(2A)R's effects on cognitive functions have been restricted to a small subset of cognitive domains. Furthermore, the relative contribution of A(2A)Rs in distinct brain regions remains largely unknown. Here, we studied the regulation of multiple memory processes by brain region-specific populations of A(2A)Rs. Specifically, we evaluated the cognitive impacts of conditional A(2A)R deletion restricted to either the entire forebrain (i.e., cerebral cortex, hippocampus, and striatum, fb-A(2A)R KO) or to striatum alone (st-A(2A)R KO) in recognition memory, working memory, reference memory, and reversal learning. This comprehensive, comparative analysis showed for the first time that depletion of A(2A)R-dependent signaling in either the entire forebrain or striatum alone is associated with two specific phenotypes indicative of cognitive flexibility-enhanced working memory and enhanced reversal learning. These selective pro-cognitive phenotypes seemed largely attributed to inactivation of striatal A(2A)Rs as they were captured by A(2A)R deletion restricted to striatal neurons. Neither spatial reference memory acquisition nor spatial recognition memory were grossly affected, and no evidence for compensatory changes in striatal or cortical D(1), D(2), or A(1) receptor expression was found. This study provides the first direct demonstration that targeting striatal A(2A)Rs may be an effective, novel strategy to facilitate cognitive flexibility under normal and pathologic conditions.     

Gender and Relationship Roles in the Analects and the Mencius

In this paper I argue that the conception of gender as illustrated in the Analects and the Mencius is basically a functional one that assigns women a domestic role. I show how this conception might imply the exclusion of women from the moral ideal of chun-tzu, which would result in the further subordination of women as wives to men as husbands in the context of the Confucian role system. On the other hand, I show how the Confucian role system can have a positive influence on the status of women through its elements of reciprocity and respect. Finally, I argue that the conception itself is not justified.     

Associative and strategic components of episodic memory: a life-span dissociation

The authors investigated the strategic component (i.e., elaboration and organization of episodic features) and the associative component (i.e., binding processes) of episodic memory and their interactions in 4 age groups (10-12, 13-15, 20-25, and 70-75 years of age). On the basis of behavioral and neural evidence, the authors hypothesized that the two components are functionally related but follow different life-span gradients. In a fully crossed design, age differences in recognition memory for single words versus word pairs (associative demand manipulation) were examined under instructions that emphasized item, pair, or elaborative-pair encoding (strategy manipulation). As predicted, the results showed that the strategic and associative components follow different life-span trajectories. Relative to younger adults, children's difficulties in episodic memory primarily reflected lower levels of strategic functioning. In contrast, older adults showed impairments in both strategic and associative components. The authors conclude that the comparison of strategic and associative components of episodic memory across the life span helps to delineate the two components' unique and interactive contributions to episodic memory performance.     

Discrimination of vowel sounds of very short duration

An experiment was conducted to investigate the discrimination of six vowel sounds of 10 msec duration. Vowels of equal pitch and intensity level were generated by computer. Both phonetically trained (PT) and untrained (UPT) Ss were used. Rapid learning took place, and the PT Ss showed much better discrimination than the UPT Ss. Confusion matrices of the last four learning blocks indicated that /i/ and /u/ sounded very much alike when they were short. The pattern of the test scores was discussed with reference to pure tone perception.     

Visual working memory for simple and complex visual stimuli

Does the magical number four characterize our visual working memory (VWM) capacity for all kinds of objects, or is the capacity of VWM inversely related to the perceptual complexity of those objects? To find out how perceptual complexity affects VWM, we used a change detection task to measure VWM capacity for six types of stimuli of different complexity: colors, letters, polygons, squiggles, cubes, and faces. We found that the estimated capacity decreased for more complex stimuli, suggesting that perceptual complexity was an important factor in determining VWM capacity. However, the considerable correlation between perceptual complexity and VWM capacity declined significantly if subjects were allowed to view the sample memory display longer. We conclude that when encoding limitations are minimized, perceptual complexity affects, but does not determine, VWM capacity.     

A Profile of Chinese Family Therapists

It is helpful for professional organizations, policy makers and regulators, third-party payers, and clients to have access to empirical data about family therapists and the practice of family therapy. Nevertheless, there is no such data available in China. This study attempts to fill this gap by profiling Chinese family therapists. A questionnaire was designed and delivered to family therapists and trainees. A total of 117 questionnaires were collected and analyzed. The findings show that the majority of Chinese family therapists are female, in the age range of 31–40 years, hold master’s degrees, and attend continuous training programs that last 20–40 days over 2–3 years and short-term workshops for family therapy training. They are mainly motivated by the need for personal growth in their career choice. Most of them work in the institutional setting. They have worked in the counseling field for 6.6 years on average, and they have practiced family therapy for an average of 3.4 years. They perform counseling for 9.2 h per week, and 4 h involve working with families. They received an average of 30.6 h of family therapy supervision in the past year. They mainly see individuals and families with adolescents, and their approach is eclectic. This paper compares the findings in China with findings from North America, discusses possible reasons for differences in the findings, and provides suggestions for future development and studies of family therapy in China.