Outcomes of a Randomized Controlled Trial of Genomic Counseling for Patients Receiving Personalized and Actionable Complex Disease Reports

There has been very limited study of patients with chronic disease receiving potentially actionable genomic based results or the utilization of genetic counselors in the online result delivery process. We conducted a randomized controlled trial on 199 patients with chronic disease each receiving eight personalized and actionable complex disease reports online. Primary study aims were to assess the impact of in-person genomic counseling on 1) causal attribution of disease risk, 2) personal awareness of disease risk, and 3) perceived risk of developing a particular disease. Of 98 intervention arm participants (mean age = 57.8; 39% female) randomized for in-person genomic counseling, 76 (78%) were seen. In contrast, control arm participants (n = 101; mean age = 58.5; 54% female) were initially not offered genomic counseling as part of the study protocol but were able to access in-person genomic counseling, if they requested it, 3-months post viewing of at least one test report and post-completion of the study-specific follow-up survey. A total of 64 intervention arm and 59 control arm participants completed follow-up survey measures. We found that participants receiving in-person genomic counseling had enhanced objective understanding of the genetic variant risk contribution for multiple complex diseases. Genomic counseling was associated with lowered participant causal beliefs in genetic influence across all eight diseases, compared to control participants. Our findings also illustrate that for the majority of diseases under study, intervention arm participants believed they knew their genetic risk status better than control arm subjects. Disease risk was modified for the majority during genomic counseling, due to the assessment of more comprehensive family history. In conclusion, for patients receiving personalized and actionable genomic results through a web portal, genomic counseling enhanced their objective understanding of the genetic variant risk contribution to multiple common diseases. These results support the development of additional genomic counseling interventions to ensure a high level of patient comprehension and improve patient-centered health outcomes.     

Implicit attitudes towards people with visible difference: findings from an Implicit Association Test

Research on implicit and explicit attitudes towards those with a visible difference has provided contradictory findings. While studies suggest explicit attitudes towards those with a visible difference are positive, implicit attitudes are likely to be negative. An Implicit Association Test measured attitudes towards visible differences in 129 adults finding no evidence of negative implicit attitudes. This contrasts with previous findings and accounts of those with a visible difference who report perceiving negative behaviours by the general public. Results are discussed in terms of what is known about perceiving faces that are different, as well as socio-cultural changes. These findings provide preliminary evidence that implicit attitudes towards visible difference are not negative, and that behaviour may be a result of uncertainty regarding how to behave.     

Associations of depression status and hopelessness with blood pressure: a 24-year follow-up study

Hypertension is estimated to cause 12.8% of all deaths worldwide. Both literature and well-supported cognitive models indicate that hopelessness predicts depressive symptoms. This study aimed to test whether high levels of hopelessness are associated with increased blood pressure, as well as whether depression acts as a mediator between hopelessness and blood pressure. Data from the original 24-year longitudinal Baltimore Epidemiologic Catchment Area Study (ECA) were analyzed via linear regression (N = 917; 60.3% female; 62.9% European American; mean age = 42.96 years, SD = 16.94). Hopelessness was found to have a significant direct relationship with systolic blood pressure (SBP, p < .05), but not with diastolic blood pressure (DBP, p > .05); while depression had no significant direct relationship with SBP or with DBP. Overall, findings indicated that hopelessness has a significant relationship with SBP. Limitations and implications are discussed.     

Diffusion of novel foraging behaviour in Amazon parrots through social learning

While social learning has been demonstrated in species across many taxa, the role it plays in everyday foraging decisions is not well understood. Investigating social learning during foraging could shed light on the emergence of cultural variation in different groups. We used an open diffusion experiment to examine the spread of a novel foraging technique in captive Amazon parrots. Three groups were tested using a two-action foraging box, including experimental groups exposed to demonstrators using different techniques and control birds. We also examined the influence of agonistic and pilfering behaviour on task acquisition. We found evidence of social learning: more experimental birds than control birds interacted with and opened the box. The birds were, however, no more likely to use the demonstrated technique than the non-demonstrated one, making local or stimulus enhancement the most likely mechanism. Exhibiting aggression was positively correlated with box opening, whilst receiving aggression did not reduce motivation to engage with the box, indicating that willingness to defend access to the box was important in task acquisition. Pilfering food and success in opening the box were also positively correlated; however, having food pilfered did not affect victims’ motivation to interact with the box. In a group context, pilfering may promote learning of new foraging opportunities. Although previous studies have demonstrated that psittacines are capable of imitation, in this naturalistic set-up there was no evidence that parrots copied the demonstrated opening technique. Foraging behaviour in wild populations of Amazons could therefore be facilitated by low-fidelity social learning mechanisms.     

Couple resilience and life wellbeing in firefighters

The validity of the Couple Resilience Inventory was tested using 102 married or cohabiting firefighters. This instrument measures types of relationship behavior that often occur during stressful life events and that are expected to be associated with an ability to cope with employment in a stressful occupation. It includes scales measuring two nearly orthogonal dimensions, with one dimension pertaining to positive behavior and the other to negative. Firefighters completed an online questionnaire that included the Couple Resilience Inventory and measures of relationship satisfaction, exposure to traumatic events, and life wellbeing. In line with hypotheses, scales measuring positive and negative couple resilience were nearly orthogonal to each other, and distinct from a measure of relationship satisfaction, but both scales correlated positively with exposure to traumatic events, and both correlated in opposite directions with relationship satisfaction and life wellbeing. Results were consistent with the theoretical model and they supported instrument validity.     

At 11 months,prosody still outranks statistics

English‐learning 7.5‐month‐olds are heavily biased to perceive stressed syllables as word onsets. By 11 months, however, infants begin segmenting non‐initially stressed words from speech. Using the same artificial language methodology as Johnson and Jusczyk (2001 ), we explored the possibility that the emergence of this ability is linked to a decreased reliance on prosodic cues to word boundaries accompanied by an increased reliance on syllable distribution cues. In a baseline study, where only statistical cues to word boundaries were present, infants exhibited a familiarity preference for statistical words. When conflicting stress cues were added to the speech stream, infants exhibited a familiarity preference for stress as opposed to statistical words. This was interpreted as evidence that 11‐month‐olds weight stress cues to word boundaries more heavily than statistical cues. Experiment 2 further investigated these results with a language containing convergent cues to word boundaries. The results of Experiment 2 were not conclusive. A third experiment using new stimuli and a different experimental design supported the conclusion that 11‐month‐olds rely more heavily on prosodic than statistical cues to word boundaries. We conclude that the emergence of the ability to segment non‐initially stressed words from speech is not likely to be tied to an increased reliance on syllable distribution cues relative to stress cues, but instead may emerge due to an increased reliance on and integration of a broad array of segmentation cues.     

Factors of the psychopathic personality inventory: criterion-related validity and relationship to the BIS/BAS and five-factor models of personality

Psychopathy is a personality disorder that includes interpersonal-affective and antisocial deviance features. The Psychopathic Personality Inventory (PPI) contains two underlying factors (fearless dominance and impulsive antisociality) that may differentially tap these two sets of features. In a mixed-gender sample of undergraduates and prisoners, we found that PPI fearless dominance was related to low Behavioral Inhibition System activity, high Behavioral Activation System (BAS) activity, expert prototype psychopathy scores, and primary psychopathy. Impulsive antisociality was related to high BAS activity and all psychopathy measures. High Extraversion and Openness and low Neuroticism and Agreeableness predicted fearless dominance, whereas high Neuroticism and low Agreeableness and Conscientiousness predicted impulsive antisociality. Although low levels of Agreeableness predicted both PPI factors, their differential relations with other five-factor model traits highlight differences in the way psychopathy manifests itself. Consistent with movements toward assessing personality disorder using the five-factor model, the authors report regression-based equations for the clinical assessment of these psychopathy dimensions using the NEO Personality Inventory-Revised (NEO-PI-R).     

Detecting changes in simulated events II: Using variations of momentary time‐sampling to measure changes in duration events

The extent to which a greater proportion of small behavior changes could be detected with momentary time‐sampling (MTS) was evaluated by (a) combining various interval sizes of partial‐interval recording (PIR) with 20 s, 30 s, 1 min MTS and (b) using variable interval sizes of MTS that were based on means of 20 s and 1 min. For each targeted percentage, low, moderate, and high inter‐response times (IRTs) to event‐run ratios were compared with reversal designs to determine whether sensitivity increased with either variation of MTS. The results showed that (a) combinations of 30 s and 1 min MTS/PIR yielded increased sensitivity over MTS alone; however, the increased sensitivity was offset by an increased probability of generating false positives and (b) variable‐interval MTS produced comparable sensitivity to fixed‐interval MTS. Thus, none of the methods increased detection of small behavior changes (decreased false negatives) without also increasing false positives. Copyright © 2009 John Wiley & Sons, Ltd.     

An exploratory field experiment of the effect of subconscious and conscious goals on employee performance

The effect of both a primed and a conscious goal on performance in the workplace was investigated. The primed goal was pilot tested. People on their way to work (n = 52) shown a photo of a woman winning a race performed better on a brainstorming task within a 2-min time period than people in the control group. A laboratory experiment (n = 71) revealed that this primed goal significantly increased the participants’ subconscious need for achievement, as measured by a projective test, relative to those in the control group. A 2 (primed goal vs. control group) × 2 (conscious goal vs. do best goal) factorial design involving call center employees (n = 81) revealed a main effect for this primed goal, as well as a main effect for a conscious goal for money solicited from donors.     

Cross-linguistic relations between quantifiers and numerals in language acquisition: Evidence from Japanese

A study of 104 Japanese-speaking 2- to 5-year-olds tested the relation between numeral and quantifier acquisition. A first study assessed Japanese children’s comprehension of quantifiers, numerals, and classifiers. Relative to English-speaking counterparts, Japanese children were delayed in numeral comprehension at 2 years of age but showed no difference at 3 and 4 years of age. Also, Japanese 2-year-olds had better comprehension of quantifiers, indicating that their delay was specific to numerals. A second study examined the speech of Japanese and English caregivers to explore the syntactic cues that might affect integer acquisition. Quantifiers and numerals occurred in similar syntactic positions and overlapped to a greater degree in English than in Japanese. Also, Japanese nouns were often dropped, and both quantifiers and numerals exhibited variable positions relative to the nouns they modified. We conclude that syntactic cues in English facilitate bootstrapping numeral meanings from quantifier meanings and that such cues are weaker in classifier languages such as Japanese.