The Portuguese version of Addenbrooke’s Cognitive Examination–Revised (ACE-R) in the diagnosis of subcortical vascular dementia and Alzheimer’s disease

The aim of this study was to investigate the accuracy of the Portuguese version of Addenbrooke’s Cognitive Examination–Revised (ACE-R) in detecting and differentiating early stage subcortical vascular dementia (SVD) from early stage Alzheimer’s disease (AD). Ninety-two subjects (18 SVD patients, 36 AD patients, and 38 healthy controls) were assessed using the ACE-R. Between-group’s differences were evaluated using the Quade’s rank analysis of covariance. The diagnostic accuracy and discriminatory ability of the ACE-R were examined via receiver operating characteristic (ROC) analysis. The ACE-R was able to successfully discriminate between patients and healthy subjects. The mean ACE-R total scores differed between SVD and AD patients; there were also significant differences in attention and orientation and in memory measures between the groups. An optimal cut-off of 72/73 was found for the detection of AD (sensitivity: 97%; specificity: 92%) and SVD (sensitivity: 100%; specificity: 92%).     

Jan Patočka’s sacrifice: philosophy as dissent

This article attempts to bring together the life, situation, and philosophical work of the Czech phenomenologist Jan Pato?ka in order to present his conception of philosophy and sacrifice and to understand his action of dissent and his own sacrifice as spokesman for Charter 77 in light of these concepts. Pato?ka philosophized despite being barred from teaching under the German occupation and under the communist regime, even after he was forced to retire and banned from publication. He also refused the official philosophical categories of communism and, what is more, criticized the very manner in which its ideology allowed it to function. Against the destruction of moral and political life by communist and liberal regimes alike, he outlined the necessity of a “life in the idea” that would be responsive to the notion of sacrifice. Such a position of distance from the things of the world which remains anchored among them is meant to respond to dissatisfaction with the world as it is found and is the very movement of human freedom. Taken together, these three aspects of his philosophical practice made him a dissident, a role he took on more completely when, as part of the Charter 77 movement, he publicly opposed the state, in a course of action that led to his death.     

Object and action picture naming in English and Greek

When two orthographically similar words are displayed using rapid serial visual presentation (RSVP), the repeated letters in the second critical word (W2) are not detected, leading to a deficit in reporting this word known as repetition blindness (RB). In Turkish, letters containing diacritic markings (e.g., y, ö) are considered separate letters, yet are visually highly similar to their non-diacritic analogues (s,o). Two experiments used the phenomenon of RB to investigate whether diacritic letters are represented as more similar to their non-diacritic analogues than are two unrelated letters. In Experiment 1, substantially more RB was found for words differing in just a diacritic (i y im-isim) compared to orthographic neighbours (words differing in a visually non-similar letter, such as ilim-isim). In Experiment 2, the amount of RB for identical words (isim-isim) was comparable to words that differed by a single diacritic marking (i y im-isim). We conclude that diacritic letters are mentally represented as variants of their non-diacritic analogue. Letter / word recognition researchers may be interested in pursuing these findings using standard techniques such as backward masking and orthographic priming.     

Film Review

Tell Me Who Is Haunting You and I'll Tell You Who You Are. A Reading of the film Sixth Sense dir. M. Night Shyamalan (1999)     

Probabilistic numerical discrimination in mice

Previous studies showed that both human and non-human animals can discriminate between different quantities (i.e., time intervals, numerosities) with a limited level of precision due to their endogenous/representational uncertainty. In addition, other studies have shown that subjects can modulate their temporal categorization responses adaptively by incorporating information gathered regarding probabilistic contingencies into their time-based decisions. Despite the psychophysical similarities between the interval timing and nonverbal counting functions, the sensitivity of count-based decisions to probabilistic information remains an unanswered question. In the current study, we investigated whether exogenous probabilistic information can be integrated into numerosity-based judgments by mice. In the task employed in this study, reward was presented either after few (i.e., 10) or many (i.e., 20) lever presses, the last of which had to be emitted on the lever associated with the corresponding trial type. In order to investigate the effect of probabilistic information on performance in this task, we manipulated the relative frequency of different trial types across different experimental conditions. We evaluated the behavioral performance of the animals under models that differed in terms of their assumptions regarding the cost of responding (e.g., logarithmically increasing vs. no response cost). Our results showed for the first time that mice could adaptively modulate their count-based decisions based on the experienced probabilistic contingencies in directions predicted by optimality.     

Perceived risk: an experimental investigation of consumer behavior when buying wine

The purpose of this paper is to investigate differences in expressed attitude as a function of the manner in which information on perceived risk is communicated. The experiments are conducted through a choice‐based questionnaire to reflect the consumer‐oriented decision of the purchase of a bottle of wine based on posted prices. The experiments reported in this paper are based on questionnaires distributed to 323 participants in multiple samples and examine the behavior of people when faced with different information on the probability of loss. The present study demonstrates that changes in the manner in which information is presented, without any underlying change in problem structure, affects observed preferences when buying wine. The impact of perceived risk and character on the willingness to buy and to pay for a bottle is analyzed and show that price habits and perceived risk are the main factors affecting the willingness to pay for a bottle of wine. Copyright © 2016 John Wiley & Sons, Ltd.