Developing the Individual: Life Skills and Family Therapy

Two bodies of literature on life skills and on family therapy have developed from different sources but have interesting similarities. Life skills comes from training and educational thinking, and concentrates upon the skills of and strategies for coping. Family therapy focuses upon the disturbance of an individual as symbolic of the dynamics of the family, but has at its roots a more-or-less explicit model of what constitutes an effective family, where the interactions can be readily understood in life-skill terms. The two approaches are compared and contrasted.     

Blood glucose and brain function: interactions with CNS cholinergic systems

We recently found that glucose injections attenuate amnesia and hyperactivity produced by scopolamine, a muscarinic antagonist. The present study examined whether glucose would augment behavioral effects produced by a muscarinic agonist, physostigmine. In experiment I, doses were first determined for which neither glucose (10 mg/kg) nor physostigmine (0.05 mg/kg) altered scopolamine-induced hyperactivity. However, combined glucose-physostigmine injections significantly reduced scopolamine hyperactivity. Experiment II evaluated the effects of glucose on physostigmine-induced tremors. Glucose (10, 100, and 250 mg/kg) or saline injections were given 20 min before physostigmine injections (0.4 or 0.05 mg/kg). Observations of glucose effects on the severity of physostigmine-induced tremors were then obtained at 5-min intervals for 25 min after physostigmine injections. Glucose (100 mg/kg) significantly facilitated the onset of tremors when injected before either dose of physostigmine, and augmented (at 100 and 250 mg/kg) tremor severity when injected before the lower dose of physostigmine. These findings indicate that glucose can facilitate the actions of a cholinergic agonist on two behaviors, locomotor activity and tremors, adding support to the view that circulating glucose levels can modulate central cholinergic function. More generally, the results provide additional evidence that circulating glucose levels can influence brain function.     

Novel effect of chronic corticosterone treatment on escape behavior in rats

Chronic administration of corticosterone in rats (4-35 mg/kg/day) produces a marked dose-dependent increase in the frequency of escape behavior observed when animals are held by the tail on a flat surface. The effect is fully developed after 3 days treatment. It is not the result of an increase in spontaneous motor activity since the hormone tends to reduce the latter behavior. Adrenalectomy decreases the escape behavior and tends to do so to a greater degree in rats subjected to chronic stress (restraint) than in nonstressed controls. The results suggest that endogenous corticosterone serves to maintain the above escape behavior during chronic stress.     

Evidence for a possible functional interaction between serotonergic and cholinergic mechanisms in memory retrieval

A total of three experiments were conducted. In Experiment 1, the dose-dependent effects of the pretest administration of the serotonergic agonist alaproclate and the selective muscarinic cholinergic agonist oxotremorine, alone and in combination, were assessed in a one-trial inhibitory avoidance task. A clear dose-dependent enhancement of performance was demonstrated as a result of all three treatment conditions, which could not be explained in terms of nonspecific effects of the drugs on behavior in general. In addition, the facilitation of retrieval performance produced by the combined treatment of alaproclate and oxotremorine was observed at dose levels well below those observed following administration of either compound alone. In Experiment 2 attempts were made to block the enhancements of retention resulting from the different treatment conditions (alaproclate, oxotremorine, or the combination of alaproclate and oxotremorine) by pretreating the mice with either scopolamine (a muscarinic cholinergic antagonist) or quipazine (a serotonergic agonist). The results of these experiments indicate that (a) quipazine completely blocked the enhancement of retrieval resulting from alaproclate but not that following oxotremorine or oxotremorine in combination with alaproclate, while (b) scopolamine blocked the enhancement of retrieval resulting from oxotremorine alone as well as that resulting from alaproclate plus oxotremorine but failed to block the memory enhancement resulting from alaproclate. The present results lend further support to the view that both serotonin and acetylcholine play important roles in memory retrieval. More importantly, the results of the present series of experiments provide additional support for a functional interaction between the serotonergic and cholinergic nervous systems in the mediation of behavior.     

Beidler’s theory and human taste stimulation

Beidler’s fundamental taste equation, relating response magnitude and stimulus concentration, was found to be a useful means of expressing data derived from chemoreception experiments with man. Seven L-amino acids and glycine were studied over a wide range in concentration. To a first approximation, the data are in accord with Beidler’s taste equation. Interestingly, the change in free energy (ΔF) for each stimulus was found to be small, in agreement with earlier published conclusions that the initial step in chemoreception is most likely one of adsorption. Several means of depicting these data are evaluated and their contribution to a better understanding of chemoreception is discussed.     

Memory access: The effects of fact-oriented versus problem-oriented acquisition

This study examined the effects of similarity between the processing of acquisition and the processing of test materials on performance in a problem solving task. Previous work by Perfetto, Bransford, and Franks (1983) demonstrated that uninformed subjects’ failure to utilize relevant acquisition information in a later problem solving task is the result of a failure to spontaneously access such information. The present study demonstrated that spontaneous access can be enhanced when both acquisition and test materials are processed in a similar manner, that is, in a problem-oriented manner. Furthermore, the present findings indicate that the processing similarity leading to enhanced access is specific to particular acquisition and test items, rather than a general problem solving set induced at acquisition and the subsequent testing situation. Results are interpreted within a transfer-appropriate processing perspective.