原发灶切除在转移性乳腺癌治疗中的地位

无论是国内还是世界其他国家,乳腺癌近年来已成为女性常患恶性肿瘤之首。早期乳腺癌通过手术、化疗、放疗及内分泌治疗等综合治疗后可以达到长期生存。然而对于晚期乳腺癌,特别是伴有远处转移的乳腺癌,疗效却不尽如人意。对于转移性乳腺癌,目前治疗优先选择毒性尽可能小的全身系统性治疗方案;而对于需要缓解症状或避免即将发生并发症（如皮肤溃疡、出血、真菌感染以及疼痛等）的情况可于全身治疗后行相应手术。然而对于转移性乳腺癌是否手术切除原发灶以及是否可从手术中获益,仍然充满争议。     

Mechanisms of motivation–cognition interaction: challenges and opportunities

Recent years have seen a rejuvenation of interest in studies of motivation–cognition interactions arising from many different areas of psychology and neuroscience. The present issue of Cognitive, Affective, & Behavioral Neuroscience provides a sampling of some of the latest research from a number of these different areas. In this introductory article, we provide an overview of the current state of the field, in terms of key research developments and candidate neural mechanisms receiving focused investigation as potential sources of motivation–cognition interaction. However, our primary goal is conceptual: to highlight the distinct perspectives taken by different research areas, in terms of how motivation is defined, the relevant dimensions and dissociations that are emphasized, and the theoretical questions being targeted. Together, these distinctions present both challenges and opportunities for efforts aiming toward a more unified and cross-disciplinary approach. We identify a set of pressing research questions calling for this sort of cross-disciplinary approach, with the explicit goal of encouraging integrative and collaborative investigations directed toward them.     

集体主义-个体主义文化视角下工作-家庭关系差异分析

工作-家庭关系研究是组织与管理心理学中研究的热点议题,社会文化因素是工作-家庭关系研究中的重要影响因素。本文在分析已有相关文献的基础之上,总结发现:个体主义文化下的员工工作和家庭之间的关系对等并且领域之间界限明晰,而集体主义文化下个体的工作-家庭之间的关系并非完全对等,且员工的工作和家庭之间存在更多联结。如何在现有的工作-家庭关系研究的基础上明晰适合我国文化背景的研究理论以及挖掘能够体现我国工作-家庭关系特征的研究主题是今后研究的方向与任务。     

Whatever does not kill us: cumulative lifetime adversity, vulnerability, and resilience

Exposure to adverse life events typically predicts subsequent negative effects on mental health and well-being, such that more adversity predicts worse outcomes. However, adverse experiences may also foster subsequent resilience, with resulting advantages for mental health and well-being. In a multiyear longitudinal study of a national sample, people with a history of some lifetime adversity reported better mental health and well-being outcomes than not only people with a high history of adversity but also than people with no history of adversity. Specifically, U-shaped quadratic relationships indicated that a history of some but nonzero lifetime adversity predicted relatively lower global distress, lower self-rated functional impairment, fewer posttraumatic stress symptoms, and higher life satisfaction over time. Furthermore, people with some prior lifetime adversity were the least affected by recent adverse events. These results suggest that, in moderation, whatever does not kill us may indeed make us stronger.     

试论《周易》象思维对石涛山水画的影响

象思维是中华民族的传统思维.深深影响着中国文化.<周易>蕴含着丰富的象思维,可以分为观物取象、立象尽意、得意忘象三个层面.中国画作为中华传统文化的典型代表,深受中国哲学的影响.石涛是清初著名画家,以擅长山水画闻名于世.他的画论<苦瓜和尚画语录>和其题画诗清晰地展现了其山水画深受<周易>象思维的影响,认为"画者形天地万物"、"画者从于心者也"、"不似似之当下拜".石涛山水画创作的这个过程与<周易>象思维的三个层面是一致的.     

Occupational and Industry Sex Segregation and the Work–Family Interface

This study examines how gender interacts with the extent of occupational and industry sex segregation to affect family-to-work conflict, work-to-family conflict, coworker support, and supportive work-family culture. Using a theoretical framework that highlights the negative ramifications of working in a sex-atypical occupation or industry, we hypothesized that men and women would be impacted differently by the percentage of women in an occupation or industry. The data (N?=?2,810) are from the 2002 National Study of the Changing Workforce (a US sample). Findings suggest that gender interacts with the percentage of women in an industry in significantly predicting coworker support and supportive work–family culture. Gender also interacts with the percentage of women in an occupation in significantly predicting family-to-work conflict.     

Hands-On,Shoes-Off: Multisensory Tools Enhance Family Engagement Within an Art Museum

Families with young children typically struggle to engage with traditional art museum environments. This research examined the impact of multisensory tools on family engagement within Mathaf: Arab Museum of Modern Art, Qatar. Sixty families with at least one child aged 0–11 were observed during two tasks. One task required participants to look at a series of paintings to select their favorite. In another task, families were given a toolkit of multisensory items to facilitate interaction with a painting. A semi-structured observational method produced quantitative and qualitative data about participant engagement and intergenerational interaction. Self-rating scores of task enjoyment were also collected. Results indicate that multisensory tools enhance family engagement with museums, artworks, and each other. Results also suggest that word-based interpretation was not necessary. We consider the potential implications of these findings in relation to family programming within art museums and museums more generally.     

Associations between Race and Eating Disorder Symptom Trajectories in Black and White Girls

Epidemiological research suggests racial differences in the presentation of eating disorder symptoms. However, no studies have examined associations between race and eating disorder symptom trajectories across youth and adolescence, which is necessary to inform culturally sensitive prevention programs. The purpose of the current study was to examine the trajectories of eating disorder symptoms from childhood to young adulthood and to examine whether race was associated with trajectory group membership. Data were drawn from 2,305 Black and White girls who participated in a community-based longitudinal cohort study (Pittsburgh Girls Study) examining the development of psychopathology. The child and adult versions of the Eating Attitudes Test assessed self-reported eating disorder symptoms at six time points between ages 9 and 21 years. Growth mixture modeling was used to examine developmental trajectories of dieting, bulimia/food preoccupation, and total eating disorder symptom scores. Given potential confounds with race and disordered eating, financial strain (i.e., receiving public assistance) and weight were included as covariates. Four to six distinct developmental patterns were found across eating disorder symptoms, including none, increasing, decreasing, or increasing-decreasing trajectories. Black girls had a greater likelihood of being in the decreasing trajectories for dieting, bulimia/food preoccupation, and total eating disorder symptom scores. White girls were more likely to follow increasing trajectories of dieting and total eating disorder symptom scores compared to Black girls. These results highlight the importance of examining the influence of racial background on eating disorder symptoms and the potential need for differences in the timing and focus of prevention interventions in these groups.