Characterizing the musical phenotype in individuals with Williams Syndrome.

Williams Syndrome (WS), a neurodevelopmental genetic disorder, is characterized by peaks and valleys in mental function: substantial impairments in cognitive domains such as reasoning, arithmetic ability, and spatial cognition, alongside relatively preserved skills in social domains, face processing, language, and music. We report the results of a comprehensive survey on musical behaviors and background administered to the largest sample of individuals with WS to date (n = 118, mean age = 20.4), and compare the results to those obtained from a control group of typically developing normal individuals (n = 118, mean age = 20.9) and two groups of individuals with other neurodevelopmental genetic disorders, Autism (n = 30, mean age = 18.2) and Down Syndrome (n = 40, mean age = 17.2). Individuals with WS were found to be rated higher in musical accomplishment, engagement, and interest than either of the comparison groups, and equivalent on most measures to the control group. Compared to all other groups including the controls, the WS individuals displayed greater emotional responses to music, manifested interest in music at an earlier age, and spent more hours per week listening to music. In addition, the effects of music listening (whether positive or negative) tended to last longer in the WS group. A factor analysis extracted seven principal components that characterize the musical phenotype in our sample, and discriminant function analysis of those factors was able to successfully predict group membership for the majority of cases. We discuss the neurobiological implications of these findings.     

中国消费者价格容忍度的特点

运用多维线性模型,对我国消费者对不同产品价格涨落的容忍态度进行了研究。研究对象为26384名购买过各类产品的消费者。结果表明：（1）消费者对不同产品的价格容忍度不同,对日用消费品的价格容忍度较高,对耐用消费品的价格容忍度相对较低;（2）消费者的年龄和受教育程度对价格容忍度有负向的影响,消费者的年龄和受教育程度越高,对产品的价格容忍度越低;（3）男性消费者的价格容忍度高于女性消费者,女性消费者对价格较为敏感。     

Translating Genetics Leaflets into Languages Other Than English: Lessons from an Assessment of Urdu Materials

Genetic counselors frequently counsel clients whose first language is not English, relying on interpreters and on supplementary translated written material. This paper highlights factors that counselors need to consider before using or commissioning translated leaflets. It is based on an assessment of leaflets translated into Urdu, the national language of Pakistan, which are available through U.K. genetics clinics for use with Pakistani-origin clients. The 2 authors, who know Urdu as their 2nd and 1st languages respectively, independently read each leaflet, checking for accuracy of information, ease of reading and understanding, cultural sensitivity, and contact details for Urdu-speaking professionals. There were factual errors and confusing or very difficult text in all leaflets; some leaflets also contained culturally insensitive messages that could alienate users of genetics services. The paper discusses the reasons for these pitfalls and makes recommendations to guide the future production of translated genetics leaflets.     

中等强度情绪性图片的神经机制——一项fMRI研究

采用修订后的中等唤起度的国际情绪图片为刺激材料,以12名女性大学生为被试,考察情绪性图片引起的脑激活模式。结果发现,与中性条件相比,消极情绪图片激活了枕叶、杏仁核、海马旁回和壳核。积极情绪图片引起枕叶、内侧眶额、额中回等脑区的激活,研究结果再次验证了杏仁核与消极情绪的密切关系,同时推测,内侧眶额可能是中等唤起度的趋近性积极情绪的一个脑功能区。     

A Tale of Two Standards: An Examination of Young Adults�� Endorsement of Gendered and Ageist Sexual Double Standards

Current North American sexual standards allow women to be sexual within committed relationships but may still restrict women??s sexuality to a greater extent than men??s. We investigated whether these gender double standards interact with an age double standard that describes the elderly as less sexual than the young, to create particularly limiting sexual standards for older women. 305 Canadian undergraduates completed a 2 (target age) × 2 (target gender) × 2 (participant gender) within-subjects study measuring perceptions of younger (own age) and older (over 65 years old) men??s and women??s interest in traditional sex (e.g., cuddling, intercourse with main partner) and experimental sex (e.g., extra-relationship sex, viewing erotic materials). ANCOVAs controlling for ageist and sexist beliefs revealed the ageist double standard; the elderly were perceived to be less interested in sex overall than the young. There was also a sexual double standard; women were perceived to be more interested in traditional sex than men, and men more interested in experimental sex than women. For traditional sex, women perceived younger targets as more interested than the older targets, and women targets as more interested than men. For experimental sex, a three-way interaction showed the interplay between the sexual and ageist double standards. Elderly female targets were perceived as least interested, and young male targets as most interested. Results reinforce that the current sexual standards distinguish between sex for intimacy and sex for other reasons (e.g., pleasure) and that the standards are particularly restrictive for older women.     

Ecstasy use and suicidal behavior among adolescents: findings from a national survey

The relationship between ecstasy use and suicidal behavior among adolescents in the United States was examined. Data from the adolescent subsample (ages 12-17, N = 19,301) of the 2000 National Household Survey on Drug Abuse were used in the analyses. Information on adolescent substance use, suicidal behaviors, and related sociodemographic, family, and individual factors was obtained in the survey. The rate of past year suicide attempt among adolescents with lifetime ecstasy use was almost double that of adolescents who had used other drugs only, and nine times that of adolescents with no history of illicit drug use. In multinomial logistic regression analyses controlling for related factors, the effect of ecstasy use remained significant. Adolescent ecstasy users may require enhanced suicide prevention and intervention efforts.     

The Influence of Temporal Orientation and Affective Frame on use of Ethical Decision-Making Strategies

This study examined the role of temporal orientation and affective frame in the execution of ethical decision-making strategies. In reflecting on a past experience or imagining a future experience, participants thought about experiences that they considered either positive or negative. The participants recorded their thinking about that experience by responding to several questions, and their responses were content-analyzed for the use of ethical decision-making strategies. The findings indicated that a future temporal orientation was associated with greater strategy use. Likewise, a positive affective frame was associated with greater strategy use. Future orientation may permit better strategy execution than a past orientation because it facilitates more objective, balanced contemplation of the reflected-upon situation, and minimizes potential self-threat associated with past behavior. A positive affective frame likely improves strategy execution because it facilitates active analysis of the experience. Future directions and implications of these findings are discussed.     

A STIMULUS CONTROL PROCEDURE TO DECREASE MOTOR AND VOCAL STEREOTYPY

A changing criterion design was used to examine the effects of two stimuli (a green card and a red card), conditioned via discrimination training, on reducing motor and vocal stereotypy in a youngster with autism while he looked at books. During discrimination training, motor and vocal stereotypy was not interrupted in the presence of a green stimulus, but was interrupted in the presence of a red stimulus using manual guidance and appropriate behavior was reinforced. After the participant demonstrated successful discrimination of the stimuli (i.e., the absence of stereotypy in the presence of a red stimulus and the engagement in stereotypy in the presence of a green stimulus), intervention began. During intervention, upon meeting criterion for latency to engage in motor and vocal stereotypy in the presence of the red stimulus for a target duration, the participant was provided access to the green stimulus, which signaled that motor and vocal stereotypy would not be interrupted. The criterion latency to engage in stereotypy in the presence of the red stimulus was systematically increased. Simultaneously, the duration of access to the green stimulus was systematically decreased. The red and green stimuli were faded from poster boards to colored 10 × 10 cm cards, and stimulus control was generalized to the participant's classroom and to a community setting (i.e., public library). Results are discussed in terms of discrimination training as a useful intervention for reducing motor and vocal stereotypy. Copyright © 2011 John Wiley & Sons, Ltd.     

The association between infants' self-regulatory behavior and MAOA gene polymorphism

Self-regulatory behavior in early childhood is an important characteristic that has considerable implications for the development of adaptive and maladaptive functioning. The present study investigated the relations between a functional polymorphism in the upstream region of monoamine oxidase A gene (MAOA) and self-regulatory behavior in a sample of Chinese infants at 6 months of age. Self-regulation was assessed by observing infants' behavior of orienting visual attention away from a threatening event in the laboratory situation. The results indicated that regulatory behavior was associated with the functional MAOA gene polymorphism in girls, but not boys. Girls with 4/4 genotypes displayed significantly higher regulation than girls with 3/3 and 3/4 genotypes. The present study provided evidence for gender differences on the role of MAOA gene polymorphism in socioemotional functioning in the early years.