Genetic Modulation of Neurocognitive Development in Cancer Patients throughout the Lifespan: a Systematic Review

Neuropsychology Review - The rise in cancer survival rates has raised concerns about the long-term adverse effects of cancer treatment, including neurocognitive impairment. Neurocognitive deficits...     

Relative weight of local and global properties depends on both the position of local elements and the saliency of global form

Love, Rouder, and Wisniewski (1999) and Ripoll and Marty (2005) showed that subjects could process global properties very quickly in a same/different task on abstract visual scenes for which the conspicuity of local and global properties had been controlled. In this new experiment, two important new factors were manipulated: saliency of the global pattern and location of local similarity. The results showed that the saliency of the global form as well as the location of local similarity determines the strength of global and local effects. Global effects continue to manifest themselves even when the extraction of the global form is difficult. Finally, the whole pattern of results suggests that local and global processing proceeds simultaneously and involves two attentional systems whose spatial characteristics are very different.     

Foreground contextual fear memory consolidation requires two independent phases of hippocampal ERK/CREB activation

Fear conditioning is a popular model for investigating physiological and cellular mechanisms of memory formation. In this paradigm, a footshock is either systematically associated to a tone (paired conditioning) or is pseudorandomly distributed (unpaired conditioning). In the former procedure, the tone/shock association is acquired, whereas in the latter procedure, the context/shock association will prevail. Animals with chronically implanted recording electrodes show enhanced amplitude of the extracellularly recorded field EPSP in CA1 pyramidal cells for up to 24 h after unpaired, but not paired, fear conditioning. This is paralleled by a differential activation of the ERK/CREB pathway in CA1, which is monophasic in paired conditioning (0-15 min post-conditioning), but biphasic (0-1 h and 9-12 h post-conditioning) in unpaired conditioning as revealed by immunocytochemistry and Western blotting. Intrahippocampal injection of the MEK inhibitor U0126 prior to each phase prevents the activation of both ERK1/2 and CREB after unpaired conditioning. Block of any activation phase leads to memory impairment. We finally reveal that the biphasic activation of ERK/CREB activity is independently regulated, yet both phases are critically required for the consolidation of long-term memories following unpaired fear conditioning. These data provide compelling evidence that CA1 serves different forms of memory by expressing differential cellular mechanisms that are dependent on the training regime.     

Task demand effects on postural control in older adults

The literature shows conflicting results regarding older adults' (OA) postural control performance. Differing task demands amongst scientific studies may contribute to such ambiguous results. Therefore, the purpose of this study was to examine the performance of postural control in older adults and the relationship between visual information and body sway as a function of task demands. Old and young adults (YA) maintained an upright stance on different bases of support (normal, tandem and reduced), both with and without vision, and both with and without room movement. In the more demanding tasks, the older adults displayed greater body sway than the younger adults and older adults were more influenced by the manipulation of the visual information due to the room movement. However, in the normal support condition, the influence of the moving room was similar for the two groups. These results suggest that task demand is an important aspect to consider when examining postural control in older adults.     

Dating couples' attachment styles and patterns of cortisol reactivity and recovery in response to a relationship conflict

This study investigated theoretically predicted links between attachment style and a physiological indicator of stress, salivary cortisol levels, in 124 heterosexual dating couples. Cortisol was assessed at 7 points before and after an experimental conflict negotiation task, creating a trajectory of stress reactivity and recovery for each participant. Growth modeling of cortisol data tested hypotheses that (a) insecurely attached individuals show patterns of greater physiological stress reactions to interpersonal conflict than do securely attached individuals and (b) people with insecurely attached partners show patterns of greater stress in reaction to relationship conflict than those with securely attached partners. Hypothesis 1 was supported, but men and women differed in the type of insecure attachment that predicted stress trajectories. Hypothesis 2 was supported for men, but not for women. The discussion emphasizes the role of gender role norms and partner characteristics in understanding connections between adult attachment and patterns of cortisol responses to interpersonal stress.     

The use of Tholos software for combining measures of mental workload: Toward theoretical and methodological improvements

Mental workload is a concept central to a range of disciplines (including cognitive psychology and ergonomics) that has given rise to various theoretical and methodological debates. As a result, researchers have used a number of techniques for measuring mental workload. Traditionally, three categories of measurement technique have been recognized: performance measures (e.g., the dual-task paradigm), subjective measures (e.g., rating scales), and physiological measures (e.g., heart, respiration, and blink rates). Each technique has advantages and limitations; however, some limitations may prevent an accurate evaluation of the mental workload. In this article, we focus on the benefits of combining multiple measures of mental workload. However, because combining several techniques is a very complex process, we have developed the Tholos software in an attempt to reduce this complexity. This software package uses measures from each of the three categories: a dual-task paradigm with auditory signals; the National Aeronautics and Space Administration task load index (NASA-TLX) scale and its simplified version, the “raw” task load index (RTLX); and physiological (such as pupil-dilation) measurements with which our software can merge results from the dual-task paradigm. To illustrate the benefits of using Tholos, we describe a puzzle-solving experiment in which we combined multiple measures of mental workload. The results indicate the importance of combining multiple measures to build upon the theoretical and methodological foundations of mental workload.     

Division of Household and Childcare Labor and Relationship Conflict Among Low-Income New Parents

We examine the relationships among the division of housework and childcare labor, perceptions of its fairness for two types of family labor (housework and childcare), and parents’ relationship conflict across the transition to parenthood. Perceived fairness is examined as a mediator of the relationships between change in the division of housework and childcare and relationship conflict. Working-class, dual-earner couples (n?=?108) in the U.S Northeast were interviewed at five time points from the third trimester of pregnancy and across the first year of parenthood. Research questions addressed whether change in the division of housework and childcare across the transition to parenthood predicted mothers’ and fathers’ relationship conflict, with attention to the mediating role of perceived fairness of these chores. Findings for housework indicated that perceived fairness was related to relationship conflict for mothers and fathers, such that when spouses perceived the change in the division of household tasks to be unfair to either partner, they reported more conflict, However, fairness did not significantly mediate relations between changes in division of household tasks and later relationship conflict. For childcare, fairness mediated relations between mothers’ violated expectations concerning the division of childcare and later conflict such that mothers reported less conflict when they perceived the division of childcare as less unfair to themselves; there was no relationship for fathers. Findings highlight the importance of considering both childcare and household tasks independently in our models and suggest that the division of housework and childcare holds different implications for mothers’ and fathers’ assessments of relationship conflict.     

Truth table tasks: Irrelevance and cognitive ability

Two types of truth table task are used to examine people's mental representation of conditionals. In two within-participants experiments, participants either receive the same task-type twice (Experiment 1) or are presented successively with both a possibilities task and a truth task (Experiment 2). Experiment 3 examines how people interpret the three-option possibilities task and whether they have a clear understanding of it. The present study aims to examine, for both task-types, how participants' cognitive ability relates to the classification of the truth table cases as irrelevant, and their consistency in doing so. Looking at the answer patterns, participants' cognitive ability influences their classification of the truth table cases: A positive correlation exists between cognitive ability and the number of false-antecedent cases classified as “irrelevant”, both in the possibilities task and the truth task. This favours a suppositional representation of conditionals.     

Diet and gender influences on processing and discrimination of speech sounds in 3- and 6-month-old infants: a developmental ERP study

Early post-natal nutrition influences later development, but there are no studies comparing brain function in healthy infants as a function of dietary intake even though the major infant diets differ significantly in nutrient composition. We studied brain responses (event-related potentials; ERPs) to speech sounds for infants who were fed either breast milk (BF), milk-based formula (MF), or soy formula (SF) during the first 6 months of life. Two syllables presented in an oddball paradigm elicited a late positive wave (P350) from temporal and frontal brain regions involved in language processes. All groups showed significantly greater response amplitudes to the infrequent syllable across sites at 3 months and frontally at 6 months, but significant discrimination at temporal sites was only observed at 6 months in BF infants. Decreases in response amplitudes from 3 to 6 months were greater for the frequently presented syllable, most prominent in BF infants, and greater in females than males. The results indicate greater syllable discrimination in BF than formula-fed infants, but whether this can be attributed to dietary influences alone remains unclear. Feeding method and background factor differences between breastfed and formula-fed infants may also contribute to the observed differences. The general absence of differences between formula-fed groups is notable and suggests that milk-based formula and soy formula equally support brain development and function during the first post-natal 6 months. Finally, the results indicate gender differences in the development of neural and temporal processes involved in sensory discrimination, and suggest that at 6 months these processes are better developed in females.