Chronic restraint stress impairs T-cell immunity and promotes tumor progression in mice

Long-term exposure to stressful situations can affect the immune system. The T-cell response is an important component of anti-tumoral immunity. Hence, impairment of the immune function induced by a chronic stressor has been postulated to alter the immunosurveillance of tumors, thus leading to a worse neoplastic prognosis. Here, we show that chronic restraint stress affects T-cell mediated immunity in mice. This was evidenced by a decrease of mitogen-induced T-cell proliferation, a reduction in CD4(+)T lymphocyte number and a decrease of tumor necrosis factor-alpha (TNF-alpha) and Interferon-gamma (IFN-gamma) production in stressed mice. Additionally, mice subjected to chronic restraint stress displayed an enhancement of tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival. Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the therapeutic management of stress to improve the prognosis of cancer patients.     

Ovals of time: time-space associations in synaesthesia

We examine a condition in which units of time, such as months of the year, are associated with specific locations in space. For individuals with this time-space synaesthesia, contiguous time units such as months are spatially linked forming idiosyncratically shaped patterns such as ovals, oblongs or circles. For some individuals, each time unit appears in a highly specific colour. For instance, one of the synaesthetes we studied experienced December as a red area located at arms length to the left of their body. For the same individual May was a blue area located roughly at arms length to the right of their body. We studied four synaesthetes who report spatial associations for the months of the year. We found that the time-space associations experienced by these individuals were consistent across test-retest. In addition, month names directed visual attention to particular locations in space. For some synaesthetes, this directing of spatial attention was quite rapid-in accord with their reports that month names involuntarily bring to mind spatial locations.     

Are spatial and temporal attention independent?

Participants searched for one of two target letters in a rapid serial visual presentation (RSVP) sequence of 17 successive frames, each containing four letters arranged into a box around a central fixation point. In control trial blocks, the participants had no information about when or where one of the target letters would appear. In other trial blocks, visual cues were given to indicate with 100% validity either the spatial location of the target, the time at which it would be presented, or both where and when it would appear. The results showed that both types of cues were effective on their own in speeding target identification, and their effects combined additively when the cues were presented and used together. These results support a growing body of evidence indicating that early attentional selection of information in vision is independently attuned to spatial and temporal properties of the environment.     

Aggression and sexuality in relation to toddler attachment: Implications for the caregiving system

Sexuality and aggression emerge in the second year of life as important motivational systems that organize substantial aspects of the toddler's behavior, affecting the operation of the attachment system and transforming the parents' perceptions and behaviors toward the child. The interconnection between different motivational systems in the parent and child is discussed as an important dimension in broadening our understanding of attachment in the context of the caregiving system. Normative and clinical examples are presented to illustrate how aggression and sexuality affect attachment and caregiving behaviors and representations in toddlerhood.     

Serial homicide: an investigation of behavioural consistency

To examine if serial homicide offenders are consistent across their crimes, a model was developed empirically that could be used to distinguish between crimes that were instrumental and those that were expressive. The first known three offences in each series of 69 US serial homicides committed by 23 offenders, were examined and the instrumental and expressive themes determined. Three models were then explored that test for consistency across these themes. The most liberal model was found to classify all of the offences effectively and to reveal complete consistency across the three crimes for all offenders. The implications of these results for offender profiling and further study of serial homicide are discussed. Copyright © 2005 John Wiley & Sons, Ltd.     

Comparing Personality Characteristics,Values, and Goals as Antecedents of Organizational Attractiveness

Person–organization (P–O) fit was examined as an antecedent of individuals’ attraction to organizations by operationalizing P–O fit as the similarity between individuals and organizations on three points of comparison: personality dimensions, values, and goals. It was hypothesized that compared to P–O fit on values and on goals, P–O fit on personality dimensions would be related more strongly to organizational attractiveness. It was also hypothesized that relative to P–O fit on goals, P–O fit on values would be related more strongly to organizational attractiveness. The results indicated that each of the points of comparison had a unique effect on organizational attractiveness and that individuals were more attracted to organizations that were similar to them than to organizations that were dissimilar to them.     

Affective States and Traits in the Workplace: Diary and Survey Data from Young Workers

This study investigated proposed paths of the affective events theory (AET; H. M. Weiss & R. Cropanzano, 1996), with part-time employees completing surveys at 2 points in time and completing an event-contingent diary over 2 weeks. In support of AET, negative affectivity (Time 1) related to negative emotional reactions at work. Negative emotional reactions were associated with intention to leave the job (Time 2). This relationship was especially strong for the sadness emotions (disappointed, depressed, unhappy). Positive affectivity (Time 1) directly related to job satisfaction (Time 2), but only weakly predicted positive emotional reactions at work (aggregated over 2 weeks). Qualitative data provided information about work affective events and affect-driven behaviors. Interpersonal mistreatment from customers were the most frequent cause of anger and resulted in faking expressions about 50% of the time. Recognition from supervisors for work performance was the main cause of pride.     

The Development and Evaluation of a Statewide Training Center for Home Visitors and Supervisors

This paper informs practice in community‐based home visiting workforce development by describing the development and evaluation of a university‐based training certificate program for home visitors and supervisors. The Interactive Systems Framework for Dissemination and Implementation (ISF; Wandersman et al., 2008) guides our conceptualization and paper organization. The ISF describes the components involved in translating research findings into effective implementation of prevention programs. We describe implementation and lessons learned from seven development activities: (a) review of the literature, (b) survey of other training initiatives across the country, (c) focus groups with home visitors and supervisors, (d) consultation with individual home visitors, (e) creation of a state advisory board of home visiting providers and stakeholders, (f) evaluation of two pilot trainings, and (g) video development. We then present evaluation data from 49 home visitors and 23 supervisors who completed the training certificate program after the pilot trainings. Both home visitors and supervisors rated training satisfaction highly, reported significant increases in self‐efficacy related to the training topics, and reported extensive use of motivational communication techniques, which are the foundational skills of the training content. These and other favorable results reflect the benefits of building on advances in theory and science‐based practice and of involving providers and stakeholders repeatedly throughout the development process.