Systemic and intrahippocampal administrations of the glucocorticoid receptor antagonist RU38486 impairs fear memory reconsolidation in rats

Reconsolidation is the process by which previously consolidated memories are stabilized after retrieval. Several lines of evidence indicate that glucocorticoids modulate distinct phases of learning and memory. These effects are considered to be mediated by mineralocorticoid receptors and glucocorticoid receptors (GRs), which display a high concentration and distinct distribution in the hippocampus. The role of glucocorticoid system in fear memory reconsolidation is the subject of some controversy. Moreover, we found no studies that assessed the role of hippocampal GRs in fear memory reconsolidation. Here, we investigated the effect of GR blockade on fear memory reconsolidation in rats. Rats were trained and tested in an inhibitory avoidance task. Intrahippocampal or systemic administration of the GR antagonist RU38486 immediately following memory reactivation produced a deficit in post-retrieval long-term memory that persisted over test sessions, and memory did not re-emerge following a footshock reminder. These results indicate that hippocampal GRs are required for reconsolidation of fear-based memory.     

The parenting dimensions of British Pakistani and White mothers of primary school children

There is increasing emphasis internationally on the use of parenting programmes to support the development of appropriate social behaviour in children. However, in such programmes diversity is often ignored. Research into the parenting styles and practices (dimensions) of different ethnic groups is needed in order to investigate the applicability of universal programmes, to guide their design and implementation in the future. Thirty‐four British Pakistani and 34 British White mothers of primary aged children, comprising equal numbers of males and females, completed English or Urdu versions of the Parental Dimensions Inventory—Short Version (PDI‐S), (Power, Int. J. Behav. Dev. 67 : 302–313) and a child behavioural screening instrument, the SDQ (Goodman, J. Child Psychol. Psychiatry 38 : 581–586). More similarities than differences between the parenting dimensions of Pakistani and White mothers were found overall. However, compared with White mothers, Pakistani mothers reported more ‘following through on discipline’ as well as ‘reminding’ as a disciplinary action. Further, Pakistani mothers reported following through on discipline more with boys than White mothers did and the more they reported inconsistent parenting, the more their children reportedly had behaviour problems. It is concluded that while these findings provide some support for the cross‐cultural applicability of generic parenting programmes, programme efficacy studies are also needed. Copyright © 2010 John Wiley & Sons, Ltd.     

Acceptance and commitment therapy versus tinnitus retraining therapy in the treatment of tinnitus: a randomised controlled trial

The study compared the effects of Acceptance and Commitment Therapy (ACT) with Tinnitus Retraining Therapy (TRT) on tinnitus impact in a randomised controlled trial. Sixty-four normal hearing subjects with tinnitus were randomised to one of the active treatments or a wait-list control (WLC). The ACT treatment consisted of 10 weekly 60 min sessions. The TRT treatment consisted of one 150 min session, one 30 min follow-up and continued daily use of wearable sound generators for a recommended period of at least 8 h/day for 18 months. Assessments were made at baseline, 10 weeks, 6 months and 18 months. At 10 weeks, results showed a superior effect of ACT in comparison with the WLC regarding tinnitus impact (Cohen’s d = 1.04), problems with sleep and anxiety. The results were mediated by tinnitus acceptance. A comparison between the active treatments, including all assessment points, revealed significant differences in favour of ACT regarding tinnitus impact (Cohen’s d = 0.75) and problems with sleep. At 6 months, reliable improvement on the main outcome measure was found for 54.5% in the ACT condition and 20% in the TRT condition. The results suggest that ACT can reduce tinnitus distress and impact in a group of normal hearing tinnitus patients.     

The mental representation of causal conditional reasoning: mental models or causal models

In this paper, two experiments are reported investigating the nature of the cognitive representations underlying causal conditional reasoning performance. The predictions of causal and logical interpretations of the conditional diverge sharply when inferences involving pairs of conditionals—such as if P₁then Q and if P₂then Q—are considered. From a causal perspective, the causal direction of these conditionals is critical: are the P_icauses of Q; or symptoms caused byQ. The rich variety of inference patterns can naturally be modelled by Bayesian networks. A pair of causal conditionals where Q is an effect corresponds to a “collider” structure where the two causes (P_i) converge on a common effect. In contrast, a pair of causal conditionals where Q is a cause corresponds to a network where two effects (P_i) diverge from a common cause. Very different predictions are made by fully explicit or initial mental models interpretations. These predictions were tested in two experiments, each of which yielded data most consistent with causal model theory, rather than with mental models.     

Spatial memory during progressive disorientation

Human spatial representations of object locations in a room-sized environment were probed for evidence that the object locations were encoded relative not just to the observer (egocentrically) but also to each other (allocentrically). Participants learned the locations of 4 objects and then were blindfolded and either (a) underwent a succession of 70 degrees and 200 degrees whole-body rotations or (b) were fully disoriented and then underwent a similar sequence of 70 degrees and 200 degrees rotations. After each rotation, participants pointed to the objects without vision. Analyses of the pointing errors suggest that as participants lost orientation, represented object directions generally "drifted" off of their true directions as an ensemble, not in random, unrelated directions. This is interpreted as evidence that object-to-object (allocentric) relationships play a large part in the human spatial updating system. However, there was also some evidence that represented object directions occasionally drifted off of their true directions independently of one another, suggesting a lack of allocentric influence. Implications regarding the interplay of egocentric and allocentric information are considered.     

Specificity of episodic and semantic aspects of autobiographical memory in relation to symptoms of posttraumatic stress disorder (PTSD)

Two studies examined the relationship between the ability to access specific autobiographical material in memory and presence/symptoms of posttraumatic stress. In Study 1, a sample of refugees with a diagnosis of posttraumatic stress disorder (PTSD) completed the Autobiographical Memory Test (AMT) in which they had to generate specific episodic autobiographical memories in response to emotion-related cue words. Results showed that reduced specificity of memories on the AMT was associated with an increased frequency of trauma-related flashbacks but with reduced use of effortful avoidance to deal with trauma-related intrusions in the day-to-day. Study 2 examined retrieval of semantic autobiographical information from previous lifetime periods in groups of cancer survivors with posttraumatic stress and healthy controls. The cancer survivors were able to generate fewer specific semantic details about the personal past compared to the controls. The more symptomatic survivors showed the greatest memory impairment. The data from both studies are discussed in terms of compromised access to specific autobiographical material in distressed trauma survivors reflecting a process of affect regulation.     

Genetic Counseling in Southern Iran: Consanguinity and Reason for Referral

Population based genetic counseling that promotes public health goals is an appropriate health care service. The genetic counseling center in Shiraz, southern Iran serves most of the clients in the region. During a 4-year period, 2,686 couples presented for genetic counseling. Data files revealed that 85% had consanguineous relationships (1.5% double first cousin, 74% first cousin, 8% second cousin, 1.5% beyond second cousin). Most prevalent reasons for referral were premarital counseling (80%), with 89% consanguinity, followed by preconception (12%), postnatal (7%), and prenatal counseling (1%). The most common abnormalities in probands or relatives were intellectual and developmental disabilities, hearing loss/impairment, and neuromuscular dystrophies. Family history of medical problem(s) and/or consanguinity was the main indication for referral in nearly every family. Premarital consanguinity poses unique challenges and opportunities. There is considerable opportunity for genetic counseling and education for couples in this population. The tradition of consanguinity, which is likely to persist in Iran, requires multidisciplinary agreement regarding the appropriate process of genetic counseling. Effective genetic counseling in Iran hinges on inclusion of data from genetic counseling services in national genomic and epidemiologic research programs.     

The Endorsement of Minority Rights: The Role of Group Position, National Context, and Ideological Beliefs

The present research was conducted in the Netherlands and used an experimental design to examine the endorsement of minority rights among Turkish and Kurdish participants in two framed, national contexts: the Netherlands and Turkey. In the Dutch context, each group is a minority, whereas in the Turkish context the Kurds are an oppressed national minority and the Turks are the national majority. The results showed that the Turks were less in favor of minority rights in the Turkish context than in the Dutch context, whereas the Kurds were more in favor of minority rights in the Turkish than in the Dutch context. In addition, the endorsement of minority rights was related to beliefs about majority rule, state unity, and ingroup identification, as well as to cultural diversity and perceived pervasive discrimination. The associations with the former three measures differed between the two groups and the two national contexts, whereas the latter two measures had main effects on the endorsement of minority rights.     

Philosophy of Science in Iran

First steps are taken in the following toward the study of present‐day philosophy of science in Iran, by choosing various examples in the hope of showing that philosophy of science in Iran has emerged predominantly as an apologetic and ideological discourse. I start by pointing out the complexities of method in such a study. I then criticise two writing samples by two well‐known Iranian scholars, which exemplify the first Iranian reaction to logical positivism. The study continues with a survey of the mistakes in the Persian translation of T. S. Kuhn’s The Structure of Scientific Revolutions, a study of the status of research in philosophy of science in Iran, and a critique of attempts by Iranian scholars at indigenising philosophy of science through the reconciliation of modern science with Islamic faith.