Topiramate attenuates a transient learning deficit after lesions inducing intracerebral hemorrhage

28 male Long-Evans rats prepared with lesions of the middle cerebral artery displayed deficits in spatial navigational learning in a simple version of the Morris Water Maze task not seen in animals prepared with the same injury but administered 4 treatments with topiramate after surgery.     

Noradrenergic control of odor recognition in a nonassociative olfactory learning task in the mouse

The present study examined the influence of pharmacological modulations of the locus coeruleus noradrenergic system on odor recognition in the mouse. Mice exposed to a nonrewarded olfactory stimulation (training) were able to memorize this odor and to discriminate it from a new odor in a recall test performed 15 min later. At longer delays (30 or 60 min), the familiar odor was no longer retained, and both stimuli were perceived as new ones. Following a post-training injection of the alpha(2)-adrenoceptor antagonist dexefaroxan, the familiar odor was still remembered 30 min after training. In contrast, both the alpha(2)-adrenoceptor agonist UK 14304 and the noradrenergic neurotoxin DSP-4 prevented the recognition of the familiar odor 15 min after the first exposure. Noradrenaline release in the olfactory bulb, assessed by measurement of the extracellular noradrenaline metabolite normetanephrine, was increased by 62% following dexefaroxan injection, and was decreased by 38%-44% after treatment with UK 14304 and DSP-4. Performance of mice in the recall test was reduced by a post-training injection of the beta-adrenoceptor antagonist propranolol or the alpha(1)-antagonist prazosin, thus implicating a role for beta- and alpha(1)-adrenoceptors in the facilitating effects of noradrenaline on short-term olfactory recognition in this model.     

Evaluation of communicative and linguistic development using the Spanish version of the MacArthur-Bates inventories

The MacArthur-Bates Inventories are a valid and reliable method for assessing communicative and linguistic skills in infants (8-15 months) and young children (16-30 months), and have been adapted to many languages. This paper presents their adaptation to Spanish. Structure, innovations included in the Spanish version, and the standardisation process are described, and some results obtained from the analysis of a sample of 1150 children are presented. The advantages and limitations of the use of parental report inventories are highlighted. For children before three years of age, there are very few assessment tools of language and communicative development with sufficient guarantees produced and edited in Spain. The Spanish version of the MacArthur-Bates Inventories represents an important contribution for early identification of language delays or disorders, and for follow-up of these cases.     

Addressing social determinants of health: Supporting ex-offenders’ employment through use of the Systems Theory Framework

There remains a need for counselors well-prepared to work with ex-offenders. As counselors aim to meet ethical obligations toward advocacy, they often seek to address social determinants of health (SDOH) challenges. Those working with ex-offenders should be aware of unique employment challenges ex-offenders may face and possess a baseline knowledge of the justice system for pertinent collaboration. This paper provides an explanation of how the Systems Theory Framework may be used to address ex-offenders’ employment-related needs through addressing SDOH challenges and collaborating with the justice system. Implications for employment counselors, counselor educators, and supervisors and steps for future research conclude.     

Defining and Measuring Mechanisms of Change in Psychological Therapies: The Path Not Taken

Metcalf and Dimidjian (this issue) have provided an important review of the current evidence base for mindfulness‐based cognitive therapy (MBCT) and presented a helpful summary of the proposed mechanisms of change. It is necessary to engage in a continuous dialogue regarding the evidence base for change mechanisms, and the article by Metcalf and Dimidjian highlights an important barrier of concern to the field of treatment outcome research. The present commentary aims to expand the discussion regarding the definition, measurement, and evaluation of “mechanisms of change.” Using MBCT as an example, this commentary addresses the ambiguity surrounding the definition and operationalisation of these mechanisms in research on psychological therapies and how the method of measurement may impact the results obtained in clinical trials. It is argued that a potentially fruitful avenue of future research would involve investigation of techniques, important client‐therapeutic processes, and mechanisms in a single study in order to comprehensively evaluate how change occurs.     

Where is the Faith? Using a CBPR Approach to Propose Adaptations to an Evidence-Based HIV Prevention Intervention for Adolescents in African American Faith Settings

African American adolescents are at increased risk for HIV/AIDS. Using a community-based participatory research approach, we engaged three black churches in adapting an evidence-based HIV prevention intervention, Focus on Youth (FOY)+ImPACT, for faith settings. To identify potential adaptations to increase FOY’s relevance, utility, and efficacy for faith settings, we conducted eight focus groups pre- and post-intervention. Recommendations for maintaining FOY’s core elements and enhancing its cultural authenticity include the following: incorporating faith tools, building pastor capacity, strengthening parent–child communication skills, and expanding social support for parents and youth. Engaging faith communities in adapting and implementing evidence-based HIV prevention programs could reduce HIV/AIDS disparities.     

Quality assurance in university guidance services

In Europe there is no common quality assurance framework for the delivery of guidance in higher education. Using a case study approach in four university career guidance services in England, France and Spain, this article aims to study how quality is implemented in university career guidance services in terms of strategy, standards and models, relationship with main stakeholders and quality assessment. The case study findings reveal that the services articulate their strategy and mission as dedication to providing a quality service. However, little objective assessment of programmes and procedures is actually being conducted.     

An Evaluation of the Two-Factor Model of Emotion: Clinical Moderators Within a Large,Multi-Ethnic Sample of Youth

The two-factor model of emotion clarifies the complexities of the relationship between anxiety and depression through their varying associations with positive and negative affect. Although this model’s structure has been validated in community samples of children, little research has evaluated the model among clinically referred youth. The present investigation aimed to confirm the two-factor model of emotion within a sample of clinically-referred children (N?=?879) and to investigate potential moderators of the model’s relationships within that group. Structural equation modeling demonstrated excellent fit for the two-factor model, and moderating effects for the model structure were found related to age and diagnostic category. These results support the model’s usefulness in describing patterns of psychopathology and temperament for clinically referred children and suggest the potential for a unified treatment approach to internalizing psychopathology.