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161.
Alexander Kelle 《Science and engineering ethics》2013,19(3):1121-1139
The emergence of synthetic biology holds the potential of a major breakthrough in the life sciences by transforming biology into a predictive science. The dual-use characteristics of similar breakthroughs during the twentieth century have led to the application of benignly intended research in e.g. virology, bacteriology and aerobiology in offensive biological weapons programmes. Against this background the article raises the question whether the precautionary governance of synthetic biology can aid in preventing this techno-science witnessing the same fate? In order to address this question, this paper proceeds in four steps: it firstly introduces the emerging techno-science of synthetic biology and presents some of its potential beneficial applications. It secondly analyses contributions to the bioethical discourse on synthetic biology as well as precautionary reasoning and its application to life science research in general and synthetic biology more specifically. The paper then identifies manifestations of a moderate precautionary principle in the emerging synthetic biology dual-use governance discourse. Using a dual-use governance matrix as heuristic device to analyse some of the proposed measures, it concludes that the identified measures can best be described as “patchwork precaution” and that a more systematic approach to construct a web of dual-use precaution for synthetic biology is needed in order to guard more effectively against the field’s future misuse for harmful applications. 相似文献
162.
Nicolas Feuerhahn Sabine Sonnentag Alexander Woll 《European Journal of Work and Organizational Psychology》2013,22(1):62-79
In this diary study, we tested the recovery potential of exercise activities during leisure time and examined the psychological mechanisms underlying the relation between exercise activities and affect. We hypothesized that spending time on exercise activities after work will be related to subsequent affect in the evening, and that psychological detachment from work, sense of belonging, and physical self-perceptions explain why exercise activities are related to subsequent affect. One-hundred and twenty-six participants from diverse occupations completed a diary twice a day over five consecutive work days. Multilevel analyses showed that exercise activities after work were related to positive, but not to negative affect in the evening. As proposed, psychological detachment, sense of belonging, and physical self-perceptions mediated the relation between exercise activities after work and positive affect in the evening. 相似文献
163.
Alexander J. Mussap 《Mental health, religion & culture》2013,16(2):121-127
A questionnaire was completed by 98 Muslim and 91 non-Muslim Australian women to examine the relationship between Islam and body image. Path analyses revealed that for Muslim women (but not non-Muslim women) strength of religious faith was inversely related to body dissatisfaction, body self-objectification, and dietary restraint. These relationships were mediated by increased use of modest clothing and by reduced media consumption. These results are consistent with the proposition that adherence to Islam can indirectly protect women's body image from appearance-based public scrutiny and from exposure to Western media. 相似文献
164.
Julie A. Testa Alexander I. Tröster Julie A. Fields Angela C. Gleason David P. Salmon William W. Beatty 《Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition》2013,20(3):203-214
Previous studies using the Animals Fluency Test have shown that dementia patients with Alzheimer's disease (AD), Huntington's disease (HD), or Parkinson's disease (PD) produce fewer correct words and have smaller semantic cluster sizes than controls or PD patients without dementia (PDND). Although the number of correct words generated by the patients with AD was positively correlated with mental status, cluster size, surprisingly, was not. To increase word output and increase the reliability of estimates of cluster size, semantic fluency was reexamined using the Supermarket Fluency Task. Overall, patients with HD or PD with dementia (PDD) exhibited reduced cluster sizes compared to older controls or PDND patients, but cluster sizes were only marginally reduced for patients with AD. These effects were evident only for female participants, because the cluster sizes for elderly control men were substantially smaller than those of elderly women. For the female patients with AD, cluster size was correlated with mental status, but the relationship was nonlinear. Cluster size was normal for mildly demented patients with AD, but much reduced for moderately or severely demented participants. In contrast to a previous report, in the present study the proportion of category labels generated was increased for patients with HD with dementia but not for patients with AD. This finding questions one line of evidence that semantic memory stores undergo “bottom-up” degradation in AD. Together with previous results, these findings indicate that semantic cluster size reflects efficiency of access to semantic knowledge which is similarly compromised in subcortical and cortical diseases. 相似文献
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Luigi Trojano David Linden Elia Formisano Rainer Goebel Alexander Sack Francesco Di Salle 《Journal of Cognitive Psychology》2013,25(5):653-672
We review a series of experimental studies aimed at answering some critical questions about the neural basis of spatial imagery. Our group used functional magnetic resonance imaging (fMRI) to explore the neural correlates of an online behaviourally controlled spatial imagery task without need for visual presentation—the mental clock task. Subjects are asked to imagine pairs of times that are presented acoustically and to judge at which of the two times the clock hands form the greater angle. The cortical activation elicited by this task was contrasted with that obtained during other visual, perceptual, verbal, and spatial imagery tasks in several block design studies. Moreover, our group performed an event‐related fMRI study on the clock task to investigate the representation of component cognitive processes in spatial imagery. The bulk of our findings demonstrates that cortical areas in the posterior parietal cortex (PPC), along the intraparietal sulcus, are robustly involved in spatial mental imagery and in other tasks requiring spatial transformations. PPC is bilaterally involved in different kinds of spatial judgement. Yet the degree to which right and left PPC are activated in different tasks is a function of task requirements. From event‐related fMRI data we obtained evidence that left and right PPC are activated asynchronously during the clock task and this could reflect their different functional role in subserving cognitive components of visuospatial imagery. 相似文献
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168.
Kristin L. Croyle Alexander I. Tröster Julie A. Fields Kristy A. Straits-Tröster Kelly E. Lyons Rajesh Pahwa 《Journal of clinical psychology in medical settings》2003,10(2):101-107
This study describes utilization of coping strategies and evaluates the interaction between coping strategies, depression, and quality of life (QOL) in patients with Parkinson's disease (PD) who are being considered for neurosurgical intervention. Eighty patients (mean age 61.7 years) with PD being evaluated for possible deep brain stimulation completed self-report instruments of coping strategies (Coping Responses Inventory), depression (Beck Depression Inventory), and disease-specific QOL (Parkinson's Disease Questionnaire-39). Analyses showed that patients with PD cope with the acute stressor of approaching neurosurgery through a variety of strategies, but particularly avoidant and behavioral strategies. When the correlated but apparently opposing effects of cognitive and behavioral strategies were teased apart, greater use of cognitive strategies was associated with more severe depressive symptomatology (and poorer QOL), while greater use of behavioral strategies appeared to be associated with less depression. Depressive symptomatology, in turn, was associated with poorer QOL. However, coping had minimal direct association with QOL. From this it was concluded that patients with advanced PD generate a variety of coping responses to an acute stressor such as surgery, and the use of behavioral strategies, in particular seeking of alternative enjoyable activities, may be associated with better mood if salutary effects are not overwhelmed by less helpful cognitive coping techniques. The minimization of depressive symptomatology, in turn, is associated with better QOL. 相似文献
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