Epistemic contextualism can be stated properly

It has been argued that epistemic contextualism faces the so-called factivity problem and hence cannot be stated properly. The basic idea behind this charge is that contextualists supposedly have to say, on the one hand, that knowledge ascribing sentences like “S knows that S has hands” are true when used in ordinary contexts while, on the other hand, they are not true by the standard of their own context. In my paper, I want to show that the argument to the factivity problem fails because it rests on the mistaken premise that contextualists are committed to the truth of particular ordinary knowledge attributions.     

The Twofold Task of Union

Love is practical, having to do with how we live our lives, and a central aspect of its practical orientation is the wish for union. Union is often considered in two forms—as a union of affections and as union in relationship. This paper considers both sorts of union and argues for their connection. I first discuss the union of interests in terms of the idea of attentive awareness that is focused upon the beloved individual and his or her concerns, life, and history. I then discuss union in relationship and show how this emerges from the attentive awareness in a desire to specify a determinate way of responding to the concerns that attentive awareness opens us to. I use the example of Jane Austen’s Emma throughout; the conduct of Austen’s heroine, who fails badly at loving well, shows by means of anti-example what is at stake in pursuing union as well as illustrating the close connection between the two aspects of union.     

Counter‐intuitive moral judgement following traumatic brain injury

Several neurological patient populations, including traumatic brain injury (TBI), appear to produce an abnormally ‘utilitarian’ pattern of judgements to moral dilemmas; they tend to make judgements that maximize the welfare of the majority, rather than deontological judgements based on the following of moral rules (e.g., do not harm others). However, this patient research has always used extreme dilemmas with highly valued moral rules (e.g., do not kill). Data from healthy participants, however, suggest that when a wider range of dilemmas are employed, involving less valued moral rules (e.g., do not lie), moral judgements demonstrate sensitivity to the psychological intuitiveness of the judgements, rather than their deontological or utilitarian content (Kahane et al., Social Cognitive and Affective Neuroscience, 7, 2011, 393). We sought the moral judgements of 30 TBI participants and 30 controls on moral dilemmas where content (utilitarian/deontological) and intuition (intuitive/counter‐intuitive) were measured concurrently. Overall TBI participants made utilitarian judgements in equal proportions to controls; disproportionately favouring utilitarian judgements only when they were counter‐intuitive, and deontological judgements only when they were counter‐intuitive. These results speak against the view that TBI causes a specific utilitarian bias, suggesting instead that moral intuition is broadly disrupted following TBI.     

Emergence,Reduction and the Identity and Individuation of Powers

Topoi - One recently popular way to characterise strong emergence is to say that emergent entities possess novel causal powers. However, there is little agreement concerning the nature of powers....     

Application scenarios for nonstandard log-linear models

In this article, the authors have 2 aims. First, hierarchical, nonhierarchical, and nonstandard log-linear models are defined. Second, application scenarios are presented for nonhierarchical and nonstandard models, with illustrations of where these scenarios can occur. Parameters can be interpreted in regard to their formal meaning and in regard to their magnitude. The interpretation of the meaning of parameters is the main focus of this article. Design matrices are used to describe the hypotheses tested in models and to illustrate cases in which parameters are interpretable. Also, design matrices are used to show where and how nonstandard models differ from standard hierarchical models. Coding schemes are discussed, in particular, dummy coding and effects coding. Data examples are given with data and models discussed in the literature.     

Normative Developmental Trajectories of Aggressive Behaviors in African American,American Indian,Asian American,Caucasian, and Hispanic Children and Early Adolescents

The current 5-year accelerated longitudinal investigation modeled the developmental trajectories of aggressive behaviors in 10,107 predominantly minority (>70%; African American, American Indian, Asian American, and Hispanic) children and early adolescents (Kindergarten through 8th grade, 49% female youth) from lower to lower-middle socioeconomic strata. Based on a two-part latent growth model, findings suggest that the probability and frequency of aggressive behavior use decreases slightly (linear) through the elementary school years and then increases as children move into middle school (quadratic). Though mean level differences were found across ethnic and racial groups, socioeconomic strata, and particularly by sex at initial status, rates of change over time across all groups were invariant. Findings suggest that potential socialization differences, if any, occur pre-Kindergarten in all groups.     

The Social Psychology of Black–White Interracial Interactions: Implications for Culturally Competent Clinical Practice

Social psychological research suggests that because of concerns about being perceived in stereotypical ways, people may experience negative affect and diminished attention and cognitive capacity during interracial interactions. The authors discuss this research in relation to therapy and assessment and also offer practical suggestions for ensuring culturally competent professional practice. La investigación en el campo de la psicología social sugiere que, debido a la preocupación por ser percibida de forma estereotipada, la gente puede experimentar sentimientos negativos y un nivel reducido de atención y capacidad cognitiva durante interacciones interraciales. Los autores discuten esta investigación en relación a la terapia y evaluación, y también ofrecen sugerencias prácticas para asegurar una práctica profesional culturalmente competente.     

New insights into the regulation of synaptic plasticity from an unexpected place: Hippocampal area CA2

The search for molecules that restrict synaptic plasticity in the brain has focused primarily on sensory systems during early postnatal development, as critical periods for inducing plasticity in sensory regions are easily defined. The recent discovery that Schaffer collateral inputs to hippocampal area CA2 do not readily support canonical activity-dependent long-term potentiation (LTP) serves as a reminder that the capacity for synaptic modification is also regulated anatomically across different brain regions. Hippocampal CA2 shares features with other similarly "LTP-resistant" brain areas in that many of the genes linked to synaptic function and the associated proteins known to restrict synaptic plasticity are expressed there. Add to this a rich complement of receptors and signaling molecules permissive for induction of atypical forms of synaptic potentiation, and area CA2 becomes an ideal model system for studying specific modulators of brain plasticity. Additionally, recent evidence suggests that hippocampal CA2 is instrumental for certain forms of learning, memory, and social behavior, but the links between CA2-enriched molecules and putative CA2-dependent behaviors are only just beginning to be made. In this review, we offer a detailed look at what is currently known about the synaptic plasticity in this important, yet largely overlooked component of the hippocampus and consider how the study of CA2 may provide clues to understanding the molecular signals critical to the modulation of synaptic function in different brain regions and across different stages of development.     

A Randomized, Double-Blind, Crossover Comparison of MK-0929 and Placebo in the Treatment of Adults With ADHD

Objective: Preclinical models, receptor localization, and genetic linkage data support the role of D4 receptors in the etiology of ADHD. This proof-of-concept study was designed to evaluate MK-0929, a selective D4 receptor antagonist as treatment for adult ADHD. Method: A randomized, double-blind, placebo-controlled, crossover study was conducted in adults with primary ADHD. The primary end point was changed from baseline in total score on the Adult ADHD Investigator Symptom Rating Scale following a 4-week treatment regimen. Additional measures included Clinical Global Impression-Severity Scale, Hospital Anxiety and Depression Scale, and Brown Attention Deficit Disorder Scale and D4 genotype analysis. Results: No statistically significant treatment differences were found between MK-0929 and placebo in any of the primary or secondary assessments. Conclusion: Results from this study suggest that blockade of the D4 receptor alone is not efficacious in the treatment of adult ADHD.     

Motor deficits associated with mild, chronic hyponatremia: a factor analytic study

ABSTRACT Chronic hyponatremia (CHN) has traditionally been considered asymptomatic. If symptoms are observed, they are often mistakenly attributed to the underlying disorder. However, in recent studies neuropsychological deficits have been associated with CHN. The authors sought to determine the association between CHN and motor deficits. They used previously collected data, and 41 subjects with hyponatremia were included. An exploratory factor analysis with principal component analysis (PCA) was performed (eigenvalues >1.0). Factor scores were generated for each subject based on the resultant PCA factor structure. Finally, partial correlations were computed to measure the degree of association between baseline serum sodium concentration [Na+] and individual neuropsychological factor scores with the effect of age removed. All significance tests were performed using 2-tailed comparisons with alpha level of p ≤ .05. A 3-factor model emerged accounting for 70.17% of the total variance, including 1 factor that loaded primarily with motor speed and reaction time. A significant correlation was observed between this motor factor and serum [Na+] (r = -.477, p = .002). These findings add to previous observations suggesting that CHN is associated with subtle yet harmful motor deficits.