Neurobiological Markers of Illness Onset in Psychosis and Schizophrenia: The Search for a Moving Target

In this review, we describe neuropsychological and brain imaging findings in the early stages of psychosis and schizophrenia. We focus on recent clinical high-risk studies and consider whether the evidence supports these as ‘endophenotypes’ of a vulnerability to the illness or as ‘biomarkers’ of illness onset and transition. The findings suggest that there are a number of processes at psychosis onset that may represent biomarkers of incipient illness. These neurobiological indices particularly implicate the integrity of frontal and temporal cortices, which may or may not be related to the genetics of psychosis (i.e. potential ‘endophenotypes’). However, these brain regions are dynamically changing during normal maturation, meaning that any putative neurobiological markers identified at the earliest stages of illness may be relatively unstable. We suggest that, while such measures may be readily identified as potential neurobiological markers of established illness, they are inconsistent at (or around) the time of illness onset when assessed cross-sectionally. Instead, identification of more valid risk markers may require longitudinal assessment to ascertain normal or abnormal trajectories of neurodevelopment. Accordingly, we assert that the current conceptualisations of potential biomarkers and/or ‘endophenotypes’ for schizophrenia may need to be reconsidered in the context of normal and abnormal brain maturational processes at the time of onset of psychotic disorders.     

Diversion of attention in everyday concept learning: Identification in the service of use

Many people tend to believe that natural categories have perfectly predictive defining features. They do not easily accept the family resemblance view that the features characteristic of a category are not individually sufficient to predict the category. However, common category-learning tasks do not produce this simpler-than-it-is belief. If there is no simple classification principle in a task, the participants know that fact and can report it. We argue that most category-learning tasks in which family resemblance categories are used fail to produce the everyday simpler-than-it-is belief because they encourage analysis of identification criteria during training. To simulate the learning occurring in many natural circumstances, we developed a procedure in which participants' analytic activity is diverted from the way in which the stimuli are identified to the use to which the stimuli will be put. Finally, we discuss the prevalence of this diverted analysis in everyday categorization.     

From Speechlessness to Presence

Spiritual direction, or the directed art of inner conversation, emerges from a psychological inflection in which we learn that radical inner otherness is the fuel of spirit. Spirit, manifesting between self and other incarnates through and in the subject, as well as through the other encountered as authentic subject. One individuates, then, by relating to the Self as a desiring subject. Moving in the direction of spirit, we push back dimension by dimension to get to one dimension. Eventually, we may encounter a numinous silence, an emptiness that is full.     

Do Colours Look Like Dispositions? Reply to Langsam and Others

Dispositional theories of colour have been attacked by McGinn and others on the ground that 'Colours do not look like dispositions'. Langsam has argued that on the contrary they do, in 'Why Colours Do Look Like Dispositions', The Philosophical Quarterly , 50 (2000), pp. 68–75. I make three claims. First, neither side has made its case. Secondly, it is true, at least on one interpretation, that colours do not look like dispositions. Thirdly, this does not show that dispositionalism about colours is false.     

Structural Solutions to Social Dilemmas: A Field Study on Commuters’ Willingness to Fund Improvements in Public Transit1

The present field study examined commuters’(N= 152) willingness to fund improvements in public transit. Consistent with Samuelson's (1993; Samuelson & Messick, 1995) multiattribute evaluation model of structural change in social dilemmas, support for the transit plan was higher when it was perceived to be (a) effective at reducing congestion and pollution, (b) personally beneficial, and (c) fair in terms of taxes and benefits. Also consistent with predictions, these relationships were moderated by individual differences in social value orientation (MClintock, 1968) and the consideration of future consequences (CFC; Strathman, Gleicher, Boninger, & Edwards, 1994). Prosocials responded more to the perceived fairness of the plan, while proselfs responded more to the plan's effectiveness in reducing congestion. Low CFCs responded more to the plan's personal benefits and effectiveness in reducing congestion, while high CFCs responded more to the plan's effectiveness in reducing pollution.     

Kant on Duties Regarding Nonrational Nature: Allen W. Wood

Kant's moral philosophy is grounded on the dignity of humanity as its sole fundamental value, and involves the claim that human beings are to be regarded as the ultimate end of nature. It might be thought that a theory of this kind would be incapable of grounding any conception of our relation to other living things or to the natural world which would value nonhuman creatures or respect humanity's natural environment. This paper criticizes Kant's argumentative strategy for dealing with our duties in regard to animals, but defends both his theory and most of his conclusions on these topics.     

Evaluation of meditation and relaxation on physiological response during the performance of fine motor and gross motor tasks

This study investigated the effects of meditation/relaxation on physiological responses during the performance of a fine motor and a gross motor task. A pretest-posttest control group, randomized-blocks design was used to study a group of 16 meditators and a group of 16 nonmeditators, subgroups of each who relaxed prior to performing on a pursuit-rotor tracking device as a fine motor task and to performing the Luft cycle ergometer protocol to a heart rate of 70% of age-adjusted maximum heart rate as a gross motor task. During each of these tasks heart rate, systolic blood pressure, rate-pressure-product, and EMG activity of the frontalis muscle were monitored. No significant difference in the performance of either the fine motor or the gross motor task was noted for persons practicing meditation and persons who were nonmeditators but were given the opportunity to relax prior to a motor task. Likewise, no significant difference was noted in the pattern of response to the imposed fine motor or gross motor task by meditators or relaxed nonmeditators.