Brief treatment with alprazolam and behavioral guidance in panic disorder

Abstract

Thirty-two patients with panic disorder, with or without agoraphobic limitations, were treated with alprazolam (mean dose 3.5 mg/d) plus brief behavioral guidance in an open study during eight weeks. The sample had a notorious severity in the frequency of panics and phobic avoidance but was only mildly depressed. Before starting treatment the presence of demoralized mood and extensive avoidance were significant indicators of clinical severity, whereas the presence of dizziness as a relevant somatic complaint was not related to higher severity. After eight weeks of treatment a clinical improvement equal to or exceeding 80% of change was obtained in all cases (29) who completed treatment. Ninety-two percent of the patients were panic free at the end of treatment. There were significant reductions in all the scales with comparable declines in the subgroups formed according to the presence or absence of agoraphobic avoidance and demoralization. The data suggested that moderate doses of alprazolam could be a quick and effective treatment for panic-agoraphobic patients in the short term. The behavioral guidance probably helped in reducing agoraphobic avoidance and in obtaining global good effectiveness although this awaits controlled tests. Finally, the similarity in the response to treatment regardless of the presence of extensive avoidance or demoralized mood argues in favor of not considering the different variants of panic-agoraphobic syndrome differently, at least in samples with similar severity to the present one.     

The personalisation method applied to a working memory task: Evidence of long-term working memory effects

Ericsson and Kintsch (1995) proposed that, in situations of expertise, individuals can overcome working memory limitations by using long-term working memory. It allows a greater capacity than working memory thanks to long-term memory encoding and retrieving. To test this characteristic, an adaptation of Daneman and Carpenter's (1980) reading span was used. To operationalise expertise, the personalisation method (Guida & Tardieu, 2005) was employed. In Experiment 1, a personalised group, which read reading span sentences that mentioned familiar locations, was compared to a nonpersonalised group, which read sentences with unfamiliar locations. In Experiment 2, a personalised group, which read reading span sentences with neutral locations, was encouraged to mentally personalise these locations by thinking about known locations. This group was compared to a nonpersonalised group, which was encouraged to think about unknown locations. The personalised groups were expected to store and retrieve information in long-term memory via long-term working memory more easily than the nonpersonalised groups, which had to count massively on working memory. The results showed that personalisation enhanced reading span and confirmed one implication of the long-term working memory theory: high- and low-reading-span differences could also be due to long-term memory retrieval. Finally, these results are interpreted in terms of interaction between working memory size and long-term memory knowledge, showing that participants with a lower reading span benefited more from high domain knowledge than participants with a higher reading span.     

John Wesley's Doctrine of Grace in Light of the Christian Tradition

This ecumenically minded article explores Wesley's understanding of grace both in its relation to experience – inward religion – and in relation to his doctrines of justification and sanctification. Wesley's treatments of justification and sanctification are compared to those of Luther, Calvin and Trent. His unique and ecumenical blending of traditions allowed Wesley to develop a doctrine of grace which offers significant resources to contemporary understandings of Christian life and practice.     

Paradoxes in Aulus Gellius

The noctes Atticae of Aulus Gellius contain almost all the ancient paradoxes. Nevertheless, in comparison with his philosophical sources, the author shows a shift in the perspective of his approach. He analyses the `master argument' of Diodorus Chronus only from an ethical point of view and, among the seven paradoxes attributed to Eubulides of Milet, he quotes the `heap' as an absurdity (absurdum), the `horned one' and the `not-someone' as a trap (captio), the `liar' as a sophism (sophisma). Following the advice of Cynics, Gellius mistrusts deceptive manoeuvres, which highlight gaps in binary logic. At the same time, however, he is interested in argumentative structures, which lead one of two opponents on to victory. The extensive report of the quarrel between Protagoras and Evathlus, and many observations of Gellius on convertible forms of reasoning in literary texts fall within this rhetorical field.     

Testing the Factor Structure and Measurement Invariance Across Gender of the Big Five Inventory Through Exploratory Structural Equation Modeling

Confirmatory factor analyses (CFAs) typically fail to support the a priori 5-factor structure of Big Five self-report instruments, due in part to the overly restrictive CFA assumptions. We show that exploratory structural equation modeling (ESEM), an integration of CFA and exploratory factor analysis, overcomes these problems in relation to responses to the 44-item Big Five Inventory (BFI) administered to a large Italian community sample. ESEM fitted the data better and resulted in less correlated factors than CFA, although ESEM and CFA factor scores correlated at near unity with observed raw scores. Tests of gender invariance with a 13-model taxonomy of full measurement invariance showed that the factor structure of the BFI is gender-invariant and that women score higher on Neuroticism, Agreeableness, Extraversion, and Conscientiousness. Through ESEM one could address substantively important issues about BFI psychometric properties that could not be appropriately addressed through traditional approaches.