Different involvement of type 1, 2, and 3 ryanodine receptors in memory processes

The administration of the ryanodine receptor (RyR) agonist 4-Cmc (0.003-9 nmol per mouse intracerebroventricularly [i.c.v.]) ameliorated memory functions, whereas the RyR antagonist ryanodine (0.0001-1 nmol per mouse i.c.v.) induced amnesia in the mouse passive avoidance test. The role of the type 1, 2, and 3 RyR isoforms in memory processes was then evaluated by inhibiting the expression of the three RyR proteins in the mouse brain. A selective knockdown of the RyR isoforms was obtained by the i.c.v. administration of antisense oligonucleotides (aODNs) complementary to the sequence of RyR1, RyR2 and RyR3 proteins, as demonstrated by immunoblotting experiments. RyR1 (5-9 nmol per mouse i.c.v.) knockdown mice did not show any memory dysfunction. Conversely, RyR2 (1-7 nmol per mouse i.c.v.) and RyR3 (1-7 nmol per mouse i.c.v.) knockdown animals showed an impairment of memory processes. This detrimental effect was temporary and reversible, disappearing 7 d after the end of the aODN treatment. At the highest effective doses, none of the compounds used impaired motor coordination, as revealed by the rota rod test, nor modified spontaneous mobility and inspection activity, as revealed by the hole-board test. In conclusion, the lack of any involvement of cerebral RyR1 was demonstrated. These findings also showed the involvement of type 2 and type 3 RyR in the modulation of memory functions identifying these cerebral RyR isoforms as critical targets underlying memory processes.     

Hedwig Conrad-Martius’ Phenomenological Approach to Life Sciences and the Question of Vitalism

The philosophy of Hedwig Conrad-Martius represents a very important intersection point between phenomenological research and the natural sciences in the twentieth century. She tried to open a common pattern from the ontology of the physical being up to anthropology, passing from the biological sciences. An intersection point that, for the particular features of her thought, is rather a perspective point from which to observe, in an interesting and original way, both natural sciences and phenomenology. The 1923 essay entitled Real Ontology (Conrad-Martius 1923) is the starting point for her reflections about science, but it is also the point that marks a separation from Husserl (for a detailed discussion, see: Ales Bello 2003, pp. 184–195), even if not from phenomenology. A fundamental question is faced: “why something instead of nothing?” or: “what is the reality?,” shifting the focus from essence to existence. Whichever the answer, a deeply realistic position must be assumed, based on the assumption of a clear distinction between the subject and the world, and the possibility of knowledge, intended as adaequatio of the subject’s intellectus to the external reality.     

Attachment and God representations among lay Catholics, priests, and religious: a matched comparison study based on the Adult Attachment Interview

Based on the idea that believers' perceived relationships with God develop from their attachment-related experiences with primary caregivers, the authors explored the quality of such experiences and their representations among individuals who differed in likelihood of experiencing a principal attachment to God. Using the Adult Attachment Interview (AAI), they compared attachment-related experiences and representations in a group of 30 Catholic priests and religious with a matched group of lay Catholics and with the worldwide normal distribution of AAI classifications. They found an overrepresentation of secure-autonomous states regarding attachment among those more likely to experience a principal attachment to God (i.e., the priests and religious) compared with the other groups and an underrepresentation of unresolved-disorganized states in the two groups of Catholics compared with the worldwide normal distribution. Key findings also included links between secure-autonomous states regarding attachment and estimated experiences with loving or nonrejecting parents on the one hand and loving God imagery on the other. These results extend the literature on religion from an attachment perspective and support the idea that generalized working models derived from attachment experiences with parents are reflected in believers' perceptions of God.     

Technology from the Standpoint of Sunyata

Keiji Nishitani's critique of technology as a dehumanizing force is objected to by showing that it is possible to establish a relationship with technology characterized by the standpoint of sunyata. In order to support my claim, I offer an interpretation of sunyata as a lived experience in which knowing and being are unified. One method used to experience the identity of knowing and being is the method of negatio negationis. I argue that technology embodies this method, and that thus has a built-in process that allows users of technology to achieve a samadhi experience in the use of tools and machines. Hubert Dreyfus’ theory of embodiment is offered in support of this claim. If it is possible to establish an intimate relation with certain technologies, then the nature of technology cannot be reduced to its most obvious dehumanizing and destructive effects.     

Computer-supported learning tools: A bi-circular bi-directional framework

The paper proposes a psychological framework aimed at integrating software developers’ and teachers’ opinions about computer-supported learning tools (CSLT) with learners’ beliefs. The framework highlights how a mental model of CSLT modulates the needs and goals that motivate the use of technical instructional devices, the ways in which they are used, and the expected outcomes. The framework goes beyond a simplistic conception of the relationships between the CSLT and their effects. It stresses the importance of subjective representations and describes the network of causal relationships connecting the features of the CSLT, the user's beliefs, and the user's behaviours. The framework shows that the implementation of the CSLT is influenced by the user's mental model and that representations can change as a consequence of the use of the CSLT. The framework has implications for applied issues, suggesting a possible way to respond to a request to intervene and support an institution's attempt to introduce CSLT in training activities. In fact, the framework invites educators to clarify their tacit assumptions about CSLT and to consider trainees’ opinions; it encourages tool developers, teachers, and students to exchange their opinions in order to reach a shared conception of why and how to employ the CSLT.     

Psychometric characteristics of the Parenting Scale in a Vietnamese sample

The Parenting Scale (PS) is a well‐established instrument for measuring discipline practices in Western populations. However, whether the PS is a valid and reliable measure in Eastern populations is not known. Thus, this study examined the psychometric properties of the PS in a sample of 433 Vietnamese parents of children aged 2–7 years. Confirmatory factor analyses (CFAs) examined the commonly used Reitman et al.'s two‐factor and Rhoades and O'Leary's three‐factor solutions. Neither factor structure fit the data. An exploratory factor analysis identified a 12‐item one‐factor and 14‐item two‐factor solutions that overlapped substantially with established factor structures. The one‐factor solution reflected Lax/Overreactive parenting and the two‐factor solution consisted of Lax/Overreactive and Hostile subscales. The factor structures were confirmed via multigroup CFA. Internal consistencies were acceptable and ranged between .70 and .85. Each factor was positively associated with parent anger, dysfunctional cognitions about child behaviour, and externalising child behaviour problems. However, when entered simultaneously in a regression, Hostile discipline was not uniquely associated with child behaviour. Overall, results support the potential utility of the 12‐item one‐factor PS as a measure of dysfunctional parenting practices for Vietnamese parents.