“Nanostandardization” in Action: Implementing Standardization Processes in a Multidisciplinary Nanoparticle-Based Research and Development Project

Nanomaterials have attracted much interest in the medical field and related applications as their distinct properties in the nanorange enable new and improved diagnosis and therapies. Owing to these properties and their potential interactions with the human body and the environment, the impact of nanomaterials on humans and their potential toxicity have been regarded a very significant issue. Consequently, nanomaterials are the subject of a wide range of cutting-edge research efforts in the medical and related fields to thoroughly probe their potential beneficial utilizations and their more negative effects. We posit that the lack of standardization in the field is a serious shortcoming as it has led to the establishment of methods and results that do not ensure sufficient consistency and thus in our view can possibly result in research outputs that are not as robust as they should be. The main aim of this article is to present how NanoDiaRA, a large FP7 European multidisciplinary project that seeks to investigate and develop nanotechnology-based diagnostic systems, has developed and implemented robust, standardized methods to support research practices involving the engineering and manipulation of nanomaterials. First, to contextualize this research, an overview of the measures defined by different regulatory bodies concerning nanosafety is presented. Although these authorities have been very active in the past several years, many questions remain unanswered in our view. Second, a number of national and international projects that attempted to ensure more reliable exchanges of methods and results are discussed. However, the frequent lack of publication of procedures and protocols in research can often be a hindrance for sharing those good practices. Subsequently, the efforts made through NanoDiaRA to introduce standardized methods and techniques to support the development and utilization of nanomaterials are discussed in depth. A series of semi-structured interviews were conducted with the partners of this project, and the interviews were analyzed thematically to highlight the determined efforts of the researchers to standardize their methods. Finally, some recommendations are made toward the setting up of well-defined methods to support the high-quality work of collaborative nanoparticle-based research and development projects and to enhance standardization processes.     

Everything is subjective under water surface,too: visual illusions in fish

Animal Cognition - The study of visual illusions has captured the attention of comparative psychologists since the last century, given the unquestionable advantage of investigating complex...     

Grafting Modalities onto Substructural Implication Systems

We investigate the semantics of the logical systems obtained by introducing the modalities and into the family of substructural implication logics (including relevant, linear and intuitionistic implication). Then, in the spirit of the LDS (Labelled Deductive Systems) methodology, we "import" this semantics into the classical proof system KE. This leads to the formulation of a uniform labelled refutation system for the new logics which is a natural extension of a system for substructural implication developed by the first two authors in a previous paper.     

The Dual Value of the Web: Risks and Benefits of the Use of the Internet in Disorders with A Self-Destructive Component in Adolescents and Young Adults

Eating disorders (ED) and non-suicidal self-injury (NSSI) present common aspects and factors which contribute to their onset and development. The last decade has seen an increasing circulation of online materials and interactions connected to ED and NSSI. There is a general agreement among mental health clinicians and researchers that this kind of online content involves serious risks, such as normalization and reinforcement of unhealthy behaviors, alongside with some benefits, like receiving peer support and validation. The aim of this paper is to offer an overview of major research contributions on this topic. After describing common aspects between these disorders, we analyze data concerning the usage of harm-advocating websites on internet and the characteristics of users. Furthermore, we define and explore the contents of both pro-ED and NSSI websites, and we extensively inspect risks and benefits of the exposure to these online content. Finally, we present clinical guidelines for assessment, intervention and prevention, particularly focusing on family interventions. Due to the rapidity of changes when technology is involved, the research on this topic is far from being concluded; more in-depth studies are needed, not only to explore long term effects of the use of the websites described, but also to investigate new alarming tendencies such as the diffusion of websites challenging self-destructive behaviors.     

What’s the point? Golden and Labrador retrievers living in kennels do not understand human pointing gestures

In many studies that have investigated whether dogs’ capacities to understand human pointing gestures are aspects of evolutionary or developmental social competences, family-owned dogs have been compared to shelter dogs. However, for most of these studies, the origins of shelter dogs were unknown. Some shelter dogs may have lived with families before entering shelters, and from these past experiences, they may have learned to understand human gestures. Furthermore, there is substantial variation in the methodology and analytic approaches used in such studies (e.g. different pointing protocols, different treatment of trials with no-choice response and indoor vs. outdoor experimental arenas). Such differences in methodologies and analysis techniques used make it difficult to compare results obtained from different studies and may account for the divergent results obtained. We thus attempted to control for several parameters by carrying out a test on dynamic proximal and distal pointing. We studied eleven kennel dogs of known origin that were born and raised in a kennels with limited human interaction. This group was compared to a group of eleven dogs comparable in terms of breed, sex and age that had lived with human families since they were puppies. Our results demonstrate that pet dogs outperform kennel dogs in their comprehension of proximal and distal pointing, regardless of whether trials where no-choice was made were considered as errors or were excluded from statistical analysis, meaning that dogs living in kennels do not understand pointing gestures. Even if genetic effects of the domestication process on human–dog relationships cannot be considered as negligible, our data suggest that dogs need to learn human pointing gestures and thus underscore the importance of ontogenetic processes.     

The contributions of visual and central attention to visual working memory

We investigated the role of two kinds of attention—visual and central attention—for the maintenance of visual representations in working memory (WM). In Experiment 1 we directed attention to individual items in WM by presenting cues during the retention interval of a continuous delayed-estimation task, and instructing participants to think of the cued items. Attending to items improved recall commensurate with the frequency with which items were attended (0, 1, or 2 times). Experiments 1 and 3 further tested which kind of attention—visual or central—was involved in WM maintenance. We assessed the dual-task costs of two types of distractor tasks, one tapping sustained visual attention and one tapping central attention. Only the central attention task yielded substantial dual-task costs, implying that central attention substantially contributes to maintenance of visual information in WM. Experiment 2 confirmed that the visual-attention distractor task was demanding enough to disrupt performance in a task relying on visual attention. We combined the visual-attention and the central-attention distractor tasks with a multiple object tracking (MOT) task. Distracting visual attention, but not central attention, impaired MOT performance. Jointly, the three experiments provide a double dissociation between visual and central attention, and between visual WM and visual object tracking: Whereas tracking multiple targets across the visual filed depends on visual attention, visual WM depends mostly on central attention.     

Antonyms and Paradoxes

Adjectives can be gradable or non-gradable and this aspect of their meaning is responsible for their different distribution and also for their classification into two different classes of antonyms. Non-gradable antonyms are called contradictories: they are neither true nor false together and exclude any middle term; gradable antonyms are called contraries: they are not simultaneously true, but may be simultaneously false. While with contraries a negative disjunction (neque...neque) can define an intermediate level, with contradictories it simply means that either term of the disjunction is excluded. There are however some Latin examples, such as neque vivus neque mortuus (`neither alive nor dead'), where the negation of a contradictory pair is used to convey a third, intermediate value. This third possibility is precisely what gives place to a paradox. Such an intermediate level can be defined also by terms like semivivus, semianimis (`half-dead'). Following Ducrot's theory on argumentation, such terms represent an argumentative attenuation, not with respect to life, rather with respect to death. With contradictories, in fact, the use of semi-, like the use of negation, gives the assertion of the opposite term as a result.     

Efficient personality questionnaire for professional training

This study falls within the theoretical framework of the construct of the Efficient Personality. In this work, we present the study of validity and reliability of an original questionnaire made up of 60 items, applied to students from formative cycles of higher Professional Training. The questionnaire was reduced to 24 items, surpassing its initial .84 Cronbach alpha coefficient. Six first-order factors were obtained: Social Self-concept, Academic Self-concept, Solving Ability, Self-esteem, and Problem Coping. One second-order factor was obtained: Efficient Personality. The six-component factorial solution is similar both to the Spanish version for secondary school and to the Chilean versions for secondary and university populations, dividing the initial dimension of Self-concept into Self-concept and Self-esteem.