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111.
Angiotensin-(1-7)-induced plasticity changes in the lateral amygdala are mediated by COX-2 and NO 总被引:1,自引:1,他引:0
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Albrecht D 《Learning & memory (Cold Spring Harbor, N.Y.)》2007,14(3):177-184
It is known from studies outside the brain that upon binding to its receptor, angiotensin-(1-7) elicits the release of prostanoids and nitric oxide (NO). Cyclooxygenase (COX) is a key enzyme that converts arachidonic acid to prostaglandins. Since there are no data available so far on the role of COX-2 in the amygdala, in a first step we demonstrated that the selective COX-2 inhibitor NS-398 significantly reduced the probability of long-term potentiation (LTP) induction in the lateral nucleus of the amygdala. Similarly, in COX-2−/− mice, LTP induced by external capsule (EC) stimulation was impaired. Second, we evaluated the action of angiotensin-(1-7) in the amygdala. In wild-type mice, angiotensin-(1-7) increased LTP. This LTP-enhancing effect of Ang-(1-7) was not observed in COX-2+/− mice. However, in COX-2−/− mice, Ang-(1-7) caused an enhancement of LTP similar to that in wild-type mice. The NO synthetase inhibitor L-NAME blocked this angiotensin-(1-7)-induced increase in LTP in COX-2−/− mice. Low-frequency stimulation of external capsule fibers did not cause long-term depression (LTD) in drug-free and angiotensin-(1-7)-treated brain slices in wild-type mice. In contrast, in COX-2−/− mice, angiotensin-(1-7) caused stable LTD. Increasing NO concentration by the NO-donor SNAP also caused LTD in wild-type mice. Our study shows for the first time that LTP in the amygdala is dependent on COX-2 activity. Moreover, COX-2 is involved in the mediation of angiotensin-(1-7) effects on LTP. Finally, it is recognized that there is a molecular cross-talk between COX-2 and NO that may regulate synaptic plasticity. 相似文献
112.
The authors used the frameworks of reciprocal determinism and occupational socialization to study the effects of work characteristics (consisting of control and complexity of work) on personal initiative (PI)--mediated by control orientation (a 2nd-order factor consisting of control aspiration, perceived opportunity for control, and self-efficacy) and the reciprocal effects of PI on changes in work characteristics. They applied structural equation modeling to a longitudinal study with 4 measurement waves (N = 268) in a transitional economy: East Germany. Results confirm the model plus 1 additional, nonhypothesized effect. Work characteristics had a synchronous effect on PI via control orientation (full mediation). There were also effects of control orientation and of PI on later changes in work characteristics: As predicted, PI functioned as partial mediator, changing work characteristics in the long term (reciprocal effect); unexpectedly, there was a 2nd reciprocal effect of an additional lagged partial mediation of control orientation on later work characteristics. 相似文献
113.
Telephone versus print delivery of an individualized motivationally tailored physical activity intervention: Project STRIDE. 总被引:3,自引:0,他引:3
Bess H Marcus Melissa A Napolitano Abby C King Beth A Lewis Jessica A Whiteley Anna Albrecht Alfred Parisi Beth Bock Bernardine Pinto Christopher Sciamanna John Jakicic George D Papandonatos 《Health psychology》2007,26(4):401-409
OBJECTIVE: Given that only 25% of Americans meet physical activity recommendations, there is a need to develop and disseminate effective, evidence-based interventions to promote physical activity. The authors tested 2 delivery channels, telephone and print, to determine whether one was more effective in promoting physical activity. DESIGN: The authors randomly assigned 239 healthy, sedentary adults to (a) telephone-based individualized feedback, (b) print-based individualized feedback, or (c) contact control. Both intervention arms were guided by a motivationally tailored, theoretically driven computer expert system. MAIN OUTCOME MEASURES: Physical activity as measured by the 7-day Physical Activity Recall interview. RESULTS: At 6 months, both telephone and print arms significantly increased in minutes of moderate intensity physical activity compared with control, with no differences between the intervention arms. At 12 months, print participants reported a significantly greater number of moderate intensity minutes than both telephone and control participants, who did not differ. CONCLUSION: Results suggest that both telephone and print enhance the adoption of physical activity among sedentary adults; however, print interventions may be particularly effective in maintaining physical activity in the longer term. 相似文献
114.
When an observer looks at a hollow mask of a face, a normal convex face is often perceived [the hollow-face illusion--Gregory 1973, in Illusion in Nature and Art (London: Duckworth) pp 49-96]. We show that in exploring an illusory face, the eyes converge at the illusory and not at the real distances of fixated targets like the tip of the nose. The 'vergence error' appears even though the resulting disparities of the two retinal images of the target provide feedback that would allow an immediate correction. It is presumably the success of recognising a familiar object (a face) which overrides the correction of convergence. This suggests that the brain strives for a congruency of eye vergence and distance perception. 相似文献
115.
Kaili Chen Zhang C. Harry Hui Jasmine Lam Esther Yuet Ying Lau Shu-fai Cheung Doris Shui Ying Mok 《Journal of religion and health》2014,53(4):986-1002
Values are guiding principles in our life. While some studies found spiritual values to be “healthier,” Sagiv and Schwartz (Eur J Soc Psychol 30:177–198, 2000) showed that people holding non-spiritual values were higher on affective well-being. We examined the predictive power of these two types of values with a longitudinal data set collected from Chinese students mainly in Hong Kong. Structural equation modeling revealed that spiritual values (as well as family income) positively predicted quality of life a year later. Non-spiritual, self-enhancement values, did not show any association. Results suggest that developing spiritual values may promote well-being through enabling individuals to find meaning and purpose in life. 相似文献
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ulc Michal Hughes Anna E. Mari Lisandrina Troscianko Jolyon Tomek Oldich Albrecht Tom Jelnek Vclav 《Animal cognition》2022,25(4):991-1002
Animal Cognition - Egg rejection is a crucial defence strategy against brood parasitism that requires the host to correctly recognise the foreign egg. Rejection behaviour has, thus, evolved in many... 相似文献
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119.
Arnold B. Bakker Simon L. Albrecht Michael P. Leiter 《European Journal of Work and Organizational Psychology》2013,22(1):4-28
This article discusses the concept of work engagement and summarizes research on its most important antecedents. The authors formulate 10 key questions and shape a research agenda for engagement. In addition to the conceptual development and measurement of enduring work engagement, the authors discuss the importance of state work engagement. Further, they argue that the social context is crucial and may set the stage for a climate for engagement with an important role for management. Engaged employees conserve their own engagement through a process of job crafting. After discussing possible dark sides of engagement and the relationship between engagement and health, the article closes with a discussion of organizational interventions to increase work engagement. 相似文献
120.