A variant on promoter of the cannabinoid receptor 1 gene (CNR1) moderates the effect of valence on working memory

Cannabinoid receptor 1 gene (CNR1) variants have been related to affective information processing and, in particular, to stress release. Here, we aimed to examine whether the endocannabinoid system via CNR1 signaling modulates affective working memory, the memory system that transiently maintains and manipulates emotionally charged material. We focused on rs2180619 (A?>?G) polymorphism and examined genotype data collected from 231 healthy females. Analyses showed how a general positivity bias in working memory (i.e., better memory for positive words) emerged as task strings lengthened only in carriers of the major allele (AA/AG). Differently, GG carriers showed better memory for affective items in general (i.e., positive and negative words). These findings are some of the first to directly highlight the role of variant on promoter of the CNR1 gene in affective working memory and to evidence a differentiation among CNR1 genotypes in terms of larger difficulties in disengaging from negative stimuli in GG carriers.     

Subjective organization in the episodic memory of individuals with Parkinson’s disease associated with mild cognitive impairment

Word clustering (i.e., the ability to reproduce the same word pairs in consecutive recall trials of an unrelated word list) has been extensively investigated as a proxy of subjective organization (SO) of memorandum. In healthy subjects and in groups of brain-damaged patients, the rate of SO generally predicts accuracy of word list recall. This study aimed at evaluating SO in the performance of patients with Parkinson’s disease (PD) on a word list recall task in order to investigate the basic mechanisms of episodic memory impairment that are frequently observed in these patients. For this purpose, 56 PD patients, who were stratified according to the presence and quality of mild cognitive impairment (MCI), and a group of healthy controls (HCs) were administered a word list task and an extensive battery of neuropsychological tests. Results showed that recall accuracy on the word list task progressively decreased passing from HC to PD patients without cognitive impairment, to patients with single-domain dysexecutive MCI and to patients with multiple-domain dysexecutive and amnesic MCI. Conversely, only the latter PD group showed a lower SO score than that achieved by the other groups. In the overall PD group, correlational and regression analyses demonstrated that SO scores and a composite score of executive functions were not reciprocally related, but both provided an independent and significant contribution to the prediction of word list recall accuracy. These data are discussed in terms of the contribution of executive functions and hippocampal storage processes to the onset of memory impairment in PD.     

Sensori-motor integration during stance: Time adaptation of control mechanisms on adding or removing vision

Sudden addition or removal of visual information can be particularly critical to balance control. The promptness of adaptation of stance control mechanisms is quantified by the latency at which body oscillation and postural muscle activity vary after a shift in visual condition. In the present study, volunteers stood on a force platform with feet parallel or in tandem. Shifts in visual condition were produced by electronic spectacles. Ground reaction force (center of foot pressure, CoP) and EMG of leg postural muscles were acquired, and latency of CoP and EMG changes estimated by t-tests on the averaged traces. Time-to-reach steady-state was estimated by means of an exponential model. On allowing or occluding vision, decrements and increments in CoP position and oscillation occurred within about 2 s. These were preceded by changes in muscle activity, regardless of visual-shift direction, foot position or front or rear leg in tandem. These time intervals were longer than simple reaction-time responses. The time course of recovery to steady-state was about 3 s, shorter for oscillation than position. The capacity of modifying balance control at very short intervals both during quiet standing and under more critical balance conditions speaks in favor of a necessary coupling between vision, postural reference, and postural muscle activity, and of the swiftness of this sensory reweighing process.     

Jews in the diaspora with <Emphasis Type="Italic">Sepharad</Emphasis> in the mirror: ruptures,relations, and forms of identity: a theme examined through three cases

Recent historiography has led to a reevaluation of the diachronic paradigm that undergirds the classic story of Iberian Jews and conversos. In line with that reevaluation, this article investigates what motivated diasporic Sephardim, especially ones with cultural and other ties to Portugal, to conserve elements of an identity that pointed to their Iberian past, such as the Portuguese and Castilian languages, as well as what one might call “Ibero-conscious” forms of self-identification. What benefits, beyond expressing a nostalgic and otherwise emotive sensibility, could accrue from the retention of these forms? How did they and similar forms facilitate the building internal, group cohesion on the basis of shared connections to a common past? How did the forms articulate the relations of New Christians to the Iberian countries and to the Iberian Empires? To reflect on these and related questions, which focus on the continuity of ties between diasporic Jews and the Iberian Peninsula, we analyze here various temporally and geographically distinct cases: The case of the converso financier and politican Joseph Nasi (formerly João Micas); the case of the Sephardi convert and anti-Jewish polemicist, João Baptista D’Este (formerly Abraham Bendanan Serfatim); and the case of Portuguese Jews in Salé, Morocco, whose wide-ranging relations with the Portuguese Jews Community of Amsterdam and with Christian Dutchmen made for complex phenomena of identity-construction.     

Exaggerated NMDA mediated LTD in a mouse model of Down syndrome and pharmacological rescuing by memantine

The Ts65Dn mouse is the best-studied animal model for Down syndrome. In the experiments described here, NMDA-mediated or mGluR-mediated LTD was induced in the CA1 region of hippocampal slices from Ts65Dn and euploid control mice by bath application of 20 μM NMDA for 3 min and 50 μM DHPG for 5 min, respectively. We found that Ts65Dn mice display exaggerated NMDA-induced, but not mGluR-induced, LTD in the CA1 region of the hippocampus compared with euploid control animals. In addition, this abnormal level of LTD can be pharmacologically rescued by the NMDA receptor antagonist memantine.     

Predicting right-wing authoritarianism via personality and dangerous world beliefs: direct, indirect, and interactive effects

In an Italian sample (N = 483, 78.23% women, mean age = 27.61 years old), we used structural equation modeling with latent variables and interactions to analyze the direct, indirect, and interactive effects exerted on right-wing authoritarianism by the Big Five factors of personality and by dangerous world beliefs. Openness, Neuroticism, and Conscientiousness exerted direct effects on right-wing authoritarianism; the first two relationships were partially mediated by dangerous world beliefs. Most importantly, the relationship between dangerous world beliefs and right-wing authoritarianism was moderated by Openness: dangerous world beliefs significantly influenced right-wing authoritarianism solely for participants high in Openness. Limitations and possible developments of this research are discussed.     

Effect of visual field presentation on action planning (estimating reach) in children

In this article, the authors examined the effects of target information presented in different visual fields (lower, upper, central) on estimates of reach via use of motor imagery in children (5-11 years old) and young adults. Results indicated an advantage for estimating reach movements for targets placed in lower visual field (LoVF), with all groups having greater difficulty in the upper visual field (UpVF) condition, especially 5- and 7-year-olds. Complementing these results was an overall age-related increase in accuracy. Based in part on the equivalence hypothesis suggesting that motor imagery and motor planning and execution are similar, the findings support previous work of executed behaviors showing that there is a LoVF bias for motor skill actions of the hand. Given that previous research hints that the UpVF may be bias for visuospatial (perceptual) qualities, research in that area and its association with visuomotor processing (LoVF) should be considered.     

Identification of risk factors for suffering fear of hypoglycemia in type 1 Diabetes Mellitus patients

Hypoglycemia is one of the main burdens for type I Diabetes Mellitus (DM I) patients. The consequences of hypoglycemia can be quite unpleasant due to the variety of disagreeable physical and psychological symptoms it triggers. The patient's previous experience with hypoglycemia episodes will condition his psychological reaction to future episodes, promoting behavioral modifications that associate with poor glycemic control and worse prognosis, and even with developing psychological disorders, leading to fear of hypoglycemia (FH). To be able to provide tailored prevention and treatment of patients with FH it is necessary to identify the risk factors in DM I patients. We developed and validated the FH‐15 scale, a novel instrument to assess FH, which showed good concurrent and predictive validity in DM I patients. In this work we aim to identify the risk factors for suffering FH by detecting DM I patients with FH using the FH‐15 scale and then analyzing the association of clinical and sociodemographic variables. We found that age, needing help to resolve an episode of hypoglycemia, and a perceived lack of social support are risk factors for suffering FH.     

Sublexical and Lexico-Syntactic Factors in Gender Access in Spanish

The influence of sublexical and lexico-syntactic factors during the grammatical gender assignment process in Spanish was studied in two experiments using the gender decision task. In Experiment 1, the regularity of the ending of gender-marked nouns (masculine nouns ended in $-o$ and feminine nouns ended in $-a$ ) and of nouns with gender-correlated but unmarked word-endings (e.g., $-ad$ ) was manipulated. The results showed that regularity affected reaction times and error rates only in the case of gender-marked nouns, suggesting that the mere statistical distribution of a word-ending across genders is not responsible for the regularity effect. In Experiment 2, gender-marked nouns and gender-unmarked nouns were preceded by a masked prime which could be a definite article (which provides information about the gender of the noun) or a possessive pronoun (which does not contain gender information). The presentation of the definite article led to shorter reaction times and less errors only when the word-ending was different from $-o$ or $-a$ . Taken together, these results indicate that gender assignment in Spanish is carried out through different processes depending on the noun ending: gender decisions for gender-marked nouns are based on the gender-to-ending distribution. Meanwhile, gender decisions for unmarked nouns seem to require the retrieval of the corresponding definite grammatical article, regardless of the statistical distribution of the noun ending across genders.     

Reduced habituation to angry faces: increased attentional capture as to override inhibition of return

The aim of this paper was to study whether real angry faces do capture attention to the extent of overcoming the inhibition of return (IOR) effect and whether the anxiety level of participants modulates this effect by stressing biases toward threatening stimuli. With this purpose, participants categorized the emotional valence of face targets in a standard spatial cueing procedure suitable to measure IOR. In Experiment 1, participants were selected according to their high vs. low-trait anxiety, whereas in Experiment 2 participants were induced a positive vs. anxiety mood state. The typical IOR effect was observed with neutral and happy face targets, which disappeared with angry face targets. Similar results were observed for all anxiety groups and in both experiments. The results indicate that IOR is overridden when the target is a biologically relevant angry face, as highly relevant targets should suffer less from habituation to attentional capture regardless of anxiety. We suggest that these data show that attentional capture is less likely to habituate for threatening information, so that no cost is measured in detecting new threatening information appearing at recently cued locations.