Subjective organization in the episodic memory of individuals with Parkinson’s disease associated with mild cognitive impairment

Word clustering (i.e., the ability to reproduce the same word pairs in consecutive recall trials of an unrelated word list) has been extensively investigated as a proxy of subjective organization (SO) of memorandum. In healthy subjects and in groups of brain-damaged patients, the rate of SO generally predicts accuracy of word list recall. This study aimed at evaluating SO in the performance of patients with Parkinson’s disease (PD) on a word list recall task in order to investigate the basic mechanisms of episodic memory impairment that are frequently observed in these patients. For this purpose, 56 PD patients, who were stratified according to the presence and quality of mild cognitive impairment (MCI), and a group of healthy controls (HCs) were administered a word list task and an extensive battery of neuropsychological tests. Results showed that recall accuracy on the word list task progressively decreased passing from HC to PD patients without cognitive impairment, to patients with single-domain dysexecutive MCI and to patients with multiple-domain dysexecutive and amnesic MCI. Conversely, only the latter PD group showed a lower SO score than that achieved by the other groups. In the overall PD group, correlational and regression analyses demonstrated that SO scores and a composite score of executive functions were not reciprocally related, but both provided an independent and significant contribution to the prediction of word list recall accuracy. These data are discussed in terms of the contribution of executive functions and hippocampal storage processes to the onset of memory impairment in PD.     

Making and Unmaking Prejudice: Religious Affiliation Mitigates the Impact of Mortality Salience on Out‐Group Attitudes

Research inspired by terror management theory has established that being reminded of the inevitability of death (i.e., “mortality salience”) leads people to express more negative attitudes toward out‐groups. We examined the hypothesis that being affiliated with a religion may buffer individuals against this negative impact of mortality salience. Two studies, conducted in two cultures that differ in their emphasis on religiosity (the United Kingdom and Italy), supported this hypothesis. Specifically, we found that mortality salience resulted in more negative out‐group attitudes only among participants not affiliated with any religion. Further, this buffering effect of religious affiliation was not moderated by participants’ specific religious orientations or by their levels of social dominance orientation. In addition, the buffering effect did not hold when prejudice against the target out‐group was not proscribed by religious authorities. Implications for research on religion, prejudice, and terror management are discussed.     

Introduction

The articles in the symposium “Teaching Early Modern Philosophy: New Approaches” provide theoretical reflections and practical advice on new ways of teaching undergraduate survey courses in early modern philosophy. This introduction lays out the rationale for the symposium and summarizes the articles that compose it.     

Classwide Teacher Implementation of Self-Regulated Strategy Development for Writing with Students with E/BD in a Residential Facility

One promising intervention to support the writing skills of students with and at risk for emotional and behavioral disorders is self-regulated strategy development (SRSD). The purpose of this study was to extend this line of inquiry to a residential setting with teachers serving as interventionists and determine the effects of the SRSD using the STOP and DARE mnemonic for persuasive writing on the writing performance (Correct Word Sequences, Essay Elements, and Essay Quality), and academic engagement of secondary students. In addition, this study extended this line of inquiry by looking at implementation of the intervention only 2 days per week, a lower treatment intensity than previous research has used to find statistically significant gains in writing. Results of a piecewise hierarchical linear model suggest statistically significant gains were made over the course of the intervention in writing and academic engagement when compared to baseline. In addition, student variables such as writing achievement, externalizing/internalizing behavior patterns, age, and attendance predicted writing and engagement. Results of generalization, fidelity, and social validity also are reported.     

A variant on promoter of the cannabinoid receptor 1 gene (CNR1) moderates the effect of valence on working memory

Cannabinoid receptor 1 gene (CNR1) variants have been related to affective information processing and, in particular, to stress release. Here, we aimed to examine whether the endocannabinoid system via CNR1 signaling modulates affective working memory, the memory system that transiently maintains and manipulates emotionally charged material. We focused on rs2180619 (A?>?G) polymorphism and examined genotype data collected from 231 healthy females. Analyses showed how a general positivity bias in working memory (i.e., better memory for positive words) emerged as task strings lengthened only in carriers of the major allele (AA/AG). Differently, GG carriers showed better memory for affective items in general (i.e., positive and negative words). These findings are some of the first to directly highlight the role of variant on promoter of the CNR1 gene in affective working memory and to evidence a differentiation among CNR1 genotypes in terms of larger difficulties in disengaging from negative stimuli in GG carriers.     

Long-term memory for performed and observed actions: Retrieval awareness and source monitoring

The self-performed task (SPT) paradigm was employed to investigate incidental memory for action events, focusing on states of awareness at retrieval (Remembering–Knowing) and source monitoring in performed and observed actions, at delays of 1 and 2 weeks. Recognition was better for performed than observed actions, but this effect was visible only after 1 week of retention. Conversely, observed actions were associated with better source memory at both delays. When the source was correctly identified, performed and observed actions were accompanied by equal proportions of Remember judgements. However, when source monitoring was incorrect, performed actions were more frequently associated with a feeling of re-experiencing the original event, thus suggesting an enactment-related recollective superiority, although secondary to the availability of reliable contextual information.     

How much does the human medial gastrocnemius muscle contribute to ankle torques outside the sagittal plane?

Ankle movements in the frontal plane are less prominent though not less relevant than movements in the plantar or dorsal flexion direction. Walking on uneven terrains and standing on narrow stances are examples of circumstances likely imposing marked demands on the ankle medio-lateral stabilization. Following our previous evidence associating lateral bodily sways in quiet standing to activation of the medial gastrocnemius (MG) muscle, in this study we ask: how large is the MG contribution to ankle torque in the frontal plane? By arranging stimulation electrodes in a selective configuration, current pulses were applied primarily to the MG nerve branch of ten subjects. The contribution of populations of MG motor units of progressively smaller recruitment threshold to ankle torque was evaluated by increasing the stimulation amplitude by fixed amounts. From smallest intensities (12–32 mA) leading to the firstly observable MG twitches in force-plate recordings, current pulses reached intensities (56–90 mA) below which twitches in other muscles could not be observed from the skin. Key results showed a substantial MG torque contribution tending to rotate upward the foot medial aspect (ankle inversion). Nerve stimulation further revealed a linear relationship between the peak torque of ankle plantar flexion and inversion, across participants (Pearson R > .81, p < .01). Specifically, regardless of the current intensity applied, the peak torque of ankle inversion amounted to about 13% of plantar flexion peak torque. Physiologically, these results provide experimental evidence that MG activation may contribute to stabilize the body in the frontal plane, especially under situations of challenged stability.     

Perversion: a clinical possibility

Abstract

Clinical work with perverse patients presents numerous difficulties to psychoanalysis, be that due to the characteristics typical of the perverse structure, which is founded on the mechanism of disavowal, or to the inefficiency of neutrality and free association in this kind of practice. A study of existing literature on the subject and a thorough examination of their own clinical findings led the authors to propose a different kind of strategy for dealing with transference that would make clinical work with these patients plausible and indicate options for the paralyzing position that is imposed on the analyst by the perverse patient in order to derange the analytic process. By proposing an alternative for the “semblance subject-supposed-knowledge,” the authors defend the idea that clinical work with perverse patients is possible, resulting in a subject less captive of the phantasmagoric scene.

Drummond S et al. Perversion: eine klinische Möglichkeit

Klinische Arbeit mit perversen Patienten bildet zahlreiche Schwierigkeiten für die Psychoanalyse, sei es wegen der Eigenart der perversen Struktur, welche durch den Mechanismus der Verleugnung begründet wird oder sei es wegen der Ineffektivität der Neutralität und freien Assoziation bei dieser Art von Praxis. Ein Studium der vorhandenen Literatur über das Thema und eine gründliche Überprüfung eigener klinischer Befunde führte die Autoren dazu, eine unterschiedliche Art von Strategie des Umgangs mit Übertragung vorzuschlagen. Das würde klinische Arbeit mit diesen Patienten plausibel machen und auf Optionen für die paralysierende Position hinweisen, die dem Analytiker durch den perversen Patienten aufgebürdet wird, um den analytischen Prozess zu stören. Ein Alternative für das “semblance subject-supposed knowledge” vorschlagend, verteidigen die Autoren die Idee, daß klinische Arbeit mit perversen Patienten möglich ist, mit dem Ergebnis eines Subjekts, welches weniger durch die phantasmagorische Szene gefesselt ist.

Drummond S et al. perversión: una posibilidad clínica.

El trabajo clínico con pacientes perversos presenta numerosas dificultades para el psicoanálisis, puede ser debido a las características típicas de la estructura perversa, fundamentado en le mecanismo de repudio, o debido a la ineficacia de la neutralidad y asociación libre en este tipo de práctica. Un estudio de la literatura existente sobre el tema y un examen completo de los hallazgos clínicos, llevó a los autores a proponer un tipo diferente de estrategia para el manejo de la transferencia, que pudiera hacer posible el trabajo clínico con estos pacientes, también indicar opciones para la situación de paralización que estos pacientes imponen al analista para desorganizar el proceso analítico. Con la proposición de una alternativa para la “semblance-subject-supposed knowledge(apariencia del sujeto-supuesto saber),” el autor defiende la idea de que el trabajo clínico con pacientes perversos es posible, resultando un asunto menos cautivo de la escena fantasmagórica.     

Sensori-motor integration during stance: Time adaptation of control mechanisms on adding or removing vision

Sudden addition or removal of visual information can be particularly critical to balance control. The promptness of adaptation of stance control mechanisms is quantified by the latency at which body oscillation and postural muscle activity vary after a shift in visual condition. In the present study, volunteers stood on a force platform with feet parallel or in tandem. Shifts in visual condition were produced by electronic spectacles. Ground reaction force (center of foot pressure, CoP) and EMG of leg postural muscles were acquired, and latency of CoP and EMG changes estimated by t-tests on the averaged traces. Time-to-reach steady-state was estimated by means of an exponential model. On allowing or occluding vision, decrements and increments in CoP position and oscillation occurred within about 2 s. These were preceded by changes in muscle activity, regardless of visual-shift direction, foot position or front or rear leg in tandem. These time intervals were longer than simple reaction-time responses. The time course of recovery to steady-state was about 3 s, shorter for oscillation than position. The capacity of modifying balance control at very short intervals both during quiet standing and under more critical balance conditions speaks in favor of a necessary coupling between vision, postural reference, and postural muscle activity, and of the swiftness of this sensory reweighing process.