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11.
Rodrigues CS de Oliveira VZ Camargo G Osório CM de Castilhos RM Saraiva-Pereira ML Schuler-Faccini L Jardim LB 《Journal of genetic counseling》2012,21(1):101-112
Diagnostic tests are available to detect several mutations related to adult-onset, autosomal dominant, neurodegenerative diseases.
We aimed to describe our experience in a presymptomatic testing program run by the Brazilian Public Health System from 1999
to 2009. A total of 184 individuals were eligible for presymptomatic testing due to a risk for spinocerebellar ataxia (SCA)
- SCA3 (80%), Huntington’s disease (11.9%), familial amyloidotic neuropathy (4.3%), SCA1, SCA2, SCA6, or SCA7. Most were women
(70%), married (54%), and had children prior to presymptomatic testing (67%). Their mean age at entrance was 34 (SD = 11 years).
Educational level was above the average Brazilian standard. After receipt of genetic counseling, 100 individuals (54%) decided
to undergo testing; of these, 51 were carriers. Since no individual returned for post-test psychological evaluation, we conducted
a subsequent survey, unrelated to test disclosures. We contacted 57 individuals of whom 31 agreed to participate (24 had been
tested, 7 had not). Several ascertainment concerns relating to these numerous losses prevented us from generalizing our results
from this second survey. We concluded that: decision-making regarding presymptomatic testing seems to be genuinely autonomous,
since after genetic counseling half the individuals who asked for presymptomatic testing decided in favor and half decided
against it; general characteristics of Brazilians who sought presymptomatic testing were similar to many European samples
studied previously; and individuals at risk for SCA3 may be at greater risk of depression. Although no clear-cut reason emerged
for rejection of follow-up psychological sessions after presymptomatic testing, this finding suggests adjustments to our presymptomatic
testing program are necessary. 相似文献
12.
Leandro L. Di Stasi Alberto Megías Antonio Cándido Antonio Maldonado Andrés Catena 《Transportation Research Part F: Traffic Psychology and Behaviour》2012,15(4):438-444
In the last five decades, cognitive scientists and the psychologists of reasoning have dedicated a lot of effort designing usable traffic signs. This study investigated the interference effect produced by the position of the sign elements in traffic signage on response accuracy and reaction time. Sixteen drivers performed a flanker interference reaction time task. Incongruent graphical/space solutions, actually used for the airport stack-type sign, lead to increased reaction time and a reduction in the proportion of correct answers. These results suggest that incongruent visual information should be avoided, as this might impair drivers’ performance. These findings provide important information for the specification of future signage design guidelines and for improving road safety. 相似文献
13.
In a temporal double bisection task, animals learn two discriminations. In the presence of Red and Green keys, responses to Red are reinforced after 1-s samples and responses to Green are reinforced after 4-s samples; in the presence of Blue and Yellow keys, responses to Blue are reinforced after 4-s samples and responses to Yellow are reinforced after 16-s samples. Subsequently, given a choice between Green and Blue, the probability of choosing Green increases with the sample duration-the context effect. In the present study we asked whether this effect could be predicted from the stimulus generalization gradients induced by the two basic discriminations. Six pigeons learned to peck Green following 4-s samples (S(+)) but not following 1-s samples (S(-)) and to peck Red following 4-s samples (S(+)) but not following 16-s samples (S(-)). Temporal generalization gradients for Green and Red were then obtained. Finally, the pigeons were given a choice between Green and Red following sample durations ranging from 1 to 16 s. Results showed that a) the two generalization gradients had the minimum at the S(-) duration, an intermediate value between the S(-) and the S(+) durations, and the maximum at the S(+) as well as more extreme durations; b) on choice trials, preference for Green over Red increased with sample duration, the context effect; and c) the two generalization gradients predicted the average context effect well. The Learning-to-Time model accounts for the major trends in the data. 相似文献
14.
Ferrucci R Giannicola G Rosa M Fumagalli M Boggio PS Hallett M Zago S Priori A 《Cognition & emotion》2012,26(5):786-799
Some evidence suggests that the cerebellum participates in the complex network processing emotional facial expression. To evaluate the role of the cerebellum in recognising facial expressions we delivered transcranial direct current stimulation (tDCS) over the cerebellum and prefrontal cortex. A facial emotion recognition task was administered to 21 healthy subjects before and after cerebellar tDCS; we also tested subjects with a visual attention task and a visual analogue scale (VAS) for mood. Anodal and cathodal cerebellar tDCS both significantly enhanced sensory processing in response to negative facial expressions (anodal tDCS, p=.0021; cathodal tDCS, p=.018), but left positive emotion and neutral facial expressions unchanged (p>.05). tDCS over the right prefrontal cortex left facial expressions of both negative and positive emotion unchanged. These findings suggest that the cerebellum is specifically involved in processing facial expressions of negative emotion. 相似文献
15.
Predictive methods estimating mechanical internal work (Wint, i.e., work to accelerate limbs with respect to BCOM during locomotion) are needed in absence of experimental measurements. A previously proposed model equation predicts such a parameter based upon velocity, stride frequency, duty factor, and a compound critical term (q) accounting for limb geometry and inertial properties. That first predicted Wint estimate (PWint) has been validated only for young males and for a limited number of horses. The present study aimed to extend the comparison between model predictions and experimentally measured Wint (MWint) data on humans with varying gender, age, gait, velocity, and gradient. Seventy healthy subjects (males and females; 7 age groups: 6-65 years) carried out level walking and running on treadmill, at different velocities. Moreover, one of the subject groups (25-35 years) walked and ran also at several uphill/downhill gradients. Reference values of q represent the main important results: (a) males and females have similar q values; (b) q is independent on velocity and gradient. Also, different data filtering depth was found to affect MWint and, indirectly, PWint, thus also the reference q values here obtained (0.08 in level, 0.10 in gradient) suffer a - 20% underestimation with respect to the previous predicting model. Despite of this effect, the close match between MWint and PWint trends indicates that the model equation could be satisfactorily applied, in various locomotion conditions. 相似文献
16.
Espelage Dorothy L. Valido Alberto Robinson Luz E. Ingram Katherine M. El Sheikh America Woolweaver Ashley M. Koritz Laura Vincent Claudia G. Marquez Brion Walker Hill M. Svanks Rita Marmolejos Roslyn Reynoso Medina Courtney Meltsner Zeke Yalamanchi Kovida Pennefather Jordan 《Social Psychology of Education》2022,25(5):1177-1203
Social Psychology of Education - Creating effective school-wide safety mechanisms depends on understanding students' previous experiences of reporting, however, students may also be... 相似文献
17.
Maria Cotelli Mauro Adenzato Valentina Cantoni Rosa Manenti Antonella Alberici Ivan Enrici Alberto Benussi Valentina Dell’Era Elisa Bonetta Alessandro Padovani Barbara Borroni 《Cognitive, affective & behavioral neuroscience》2018,18(6):1065-1075
Behavioural variant frontotemporal dementia (bvFTD) is a form of frontotemporal degeneration characterized by early changes in personality, emotional blunting, and/or loss of empathy. Recent research has highlighted that these features may be at least partially explained by impairments in the theory of mind (ToM; i.e., the ability to understand and predict other people’s behaviour by attributing independent mental states to them). The aim of this randomized, double-blind, placebo-controlled study was to test the hypothesis that transcranial direct current stimulation (tDCS) over the medial frontal cortex (MFC) selectively enhances communicative intention processing, a specific ToM ability. Using a single-session online design, we administered a ToM task that measures the ability to represent other people’s private and communicative intentions during active or sham tDCS to 16 bvFTD patients. To assess the impact of dementia on performance on the ToM task, we included 16 age-matched healthy volunteers who were asked to perform the entire experimental ToM task. BvFTD is characterized by an impairment in the comprehension of both communicative and private intentions relative to a healthy control group and by a disproportional impairment in communicative intention compared with private intention processing. Significant and selective accuracy improvement in the comprehension of communicative intentions after active stimulation was observed in patients with bvFTD. This is the first study that analyses ToM ability in patients with bvFTD using tDCS stimulation. Our findings could potentially contribute to the development of an effective, noninvasive brain stimulation treatment of ToM impairments in patients with bvFTD. 相似文献
18.
The present study examined the psychometric properties of a brief measure of the Triarchic model of psychopathy based on the Youth Psychopathic Traits Inventory (YPI-Tri-S) among a forensic sample of detained female youth offenders (M = 16.41 years; SD = 1.19 years) from Portugal. Results supported the expected three-factor structure and cross-gender measurement invariance. The YPI-Tri-S showed good psychometric properties in terms of factor structure, internal consistency, convergent validity, discriminant validity, and criterion-related validity. Findings suggest that the YPI-Tri-S is a valid and reliable measure of the Triarchic model of psychopathy, which can be used to assess female juvenile offenders. 相似文献
19.
Exploring the social side of self‐compassion: Relations with empathy and outgroup attitudes
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Giulia Fuochi Chiara A. Veneziani Alberto Voci 《European journal of social psychology》2018,48(6):769-783
Self‐compassion is a disposition involving compassionate attitudes toward the self when facing difficulties. We argued that specific self‐compassion components might influence indicators of openness to others, such as empathy and outgroup attitudes. We hypothesized that the component called common humanity versus isolation, involving the acknowledgement that one's sufferings are shared with all the other humans, would be positively related to the other‐oriented aspects of empathy, perspective taking and empathic concern, and to improved outgroup attitudes. We also hypothesized that the mindfulness versus over‐identification component, i.e., having a balanced view of one's situation avoiding exaggerations, would be associated with lowered personal distress. In three studies, with three independent samples, we regressed empathy and outgroup attitudes on self‐compassion components, while controlling for concurrent predictors such as self‐construal and attachment styles. Results supported our hypotheses, suggesting that improvements in empathy and outgroup attitudes may be fostered by positive individual dispositions. 相似文献
20.
A large body of empirical research now shows that people are surprisingly poor at detecting significant changes in visually
presented scenes. This phenomenon is known aschange blindness in vision. A similar phenomenon occurs in audition, but to date no such effect has been documented in touch. In the present
study, we explored the ability of people to detect changes introduced between two consecutively presented vibrotactile patterns
presented over the body surface. The patterns consisted of two or three vibrotactile stimuli presented for 200 msec. The position
of one of the vibrotactile stimuli composing the display was repeatedly changed (alternating between two different positions)
on 50% of the trials, but the same pattern was presented repeatedly on the remaining trials. Three conditions were investigated:
No interval between the patterns, an empty interval between the patterns, and a masked interval between the patterns. Change
detection was near perfect in the no-interval block. Performance deteriorated somewhat in the empty-interval block, but by
far the worst change detection performance occurred in the masked-interval block. These results demonstrate that “change blindness”
can also affect tactile perception. 相似文献