Neuropsychological profile of children with cryptogenic localization related epilepsy.

Up to one third of the epilepsy population consists of children with cryptogenic localization related epilepsy (CLRE). Unfortunately, the effect of CLRE on the development is still unclear. Behavioral and academic problems have been reported, but no conclusive study concerning the impact of CLRE on neuropsychological functioning is yet published. This study was a systematic cross-sectional open clinical and nonrandomized investigation, which included 68 children with CLRE. Several neuropsychological tests were analyzed and age-related normative values were used as reference. Differences between CLRE and reference values were tested with Paired-Samples t-tests. Z scores were computed to compare the different neuropsychological tests and to inspect whether a characteristic neuropsychological profile exists for CLRE. The Independent-Samples t-test was used to explore which epilepsy factors (seizure type, seizure frequency, age at onset, duration of epilepsy, and drug load) were influencing the cognitive profile of CLRE. There seems to be a characteristic cognitive profile for children with CLRE; children with CLRE experience cognitive difficulties on a wide range of areas-in particular, alertness, mental speed, and memory. Seizure type, seizure frequency, duration of epilepsy, and drug load do not influence this neuropsychological profile. Age at onset was an important risk factor; the earlier the age at onset, the worse the cognitive performance. In spite of the influence of age at onset, the revealed profile can be seen as a stable, independent of temporary factors, neuropsychological profile for children with CLRE.     

Issues in Christian–Muslim Relations: A Malaysian Christian Perspective*

Malaysia is a democratic secular federation with Islam as its official religion. Over the last few decades, this unique model of tolerance and accommodation has been undergoing astounding developments politically, socially and economically. Intense intra-Muslim struggles coupled with increased state-mobilized Islamizing efforts have produced disturbing knock-on effects on non-Muslim minorities. Religion is so profoundly interwoven with race, ethnicity, politics and economics that it is impossible to speak of one without touching upon the others. This article aims to elucidate key practical issues affecting Christians living in a majority Islamic context. It further proposes significant policy options for managing Muslim–Christian relations in twenty-first-century Malaysia. Education is crucial for promoting interreligious harmony, religious freedom, and respect for people of different traditions. More collaborative endeavours through interfaith dialogue should help Malaysians transcend cultural, racial, linguistic and religious barriers. Both Christian and Muslim faith communities need to learn more about and from each other and to move forward towards nation-building and a common destiny.     

High impact running improves learning

Regular physical exercise improves cognitive functions and lowers the risk for age-related cognitive decline. Since little is known about the nature and the timing of the underlying mechanisms, we probed whether exercise also has immediate beneficial effects on cognition. Learning performance was assessed directly after high impact anaerobic sprints, low impact aerobic running, or a period of rest in 27 healthy subjects in a randomized cross-over design. Dependent variables comprised learning speed as well as immediate (1 week) and long-term (>8 months) overall success in acquiring a novel vocabulary. Peripheral levels of brain-derived neurotrophic factor (BDNF) and catecholamines (dopamine, epinephrine, norepinephrine) were assessed prior to and after the interventions as well as after learning. We found that vocabulary learning was 20 percent faster after intense physical exercise as compared to the other two conditions. This condition also elicited the strongest increases in BDNF and catecholamine levels. More sustained BDNF levels during learning after intense exercise were related to better short-term learning success, whereas absolute dopamine and epinephrine levels were related to better intermediate (dopamine) and long-term (epinephrine) retentions of the novel vocabulary. Thus, BDNF and two of the catecholamines seem to be mediators by which physical exercise improves learning.     

Immersiveness and physiological arousal within panoramic video-based virtual reality.

In this paper, we discuss findings from a study that used panoramic video-based virtual environments (PVVEs) to induce self-reported anger. The study assessed "immersiveness" and physiological correlates of anger arousal (i.e., heart rate, blood pressure, galvanic skin response [GSR], respiration, and skin temperature). Results indicate that over time, panoramic video-based virtual scenarios can be, at the very least, physiologically arousing. Further, it can be affirmed from the results that hypnotizability, as defined by the applied measures, interacts with group on physiological arousal measures. Hence, physiological arousal appeared to be moderated by participant hypnotizability and absorption levels.     

Supervisors safety response: a multisample confirmatory factor analysis

Supervisors Safety Response (SSR) has been closely linked to workplace safety, and, as perceived by workers, it is considered to be one of the most influential issues with regard to employees compliance with safety behaviours. This study defines and tests a bifactorial and a monofactorial model of the SSR. Two facets of the SSR were measured: (a) supervisors response toward workers safe or unsafe behaviour and (b) supervisors safety attitudes and behaviours applied to their own work. In three samples of injured blue-collar workers ( N(1) = 110, N(2) = 123, N(3) = 104), multisample confirmatory factor analyses, using maximum likelihood estimation, were conducted to test both the bifactorial and the monofactorial model. Both models provide an overall good fit, but parsimony and the high correlation between factors in the bifactorial model support the monofactorial model. Attention is drawn to the measurement of the SSR as a diagnostic tool useful in selecting intervention goals, specifically integrating supervisors safety behaviour.     

What determines the speed of lexical access: homophone or specific-word frequency? A reply to Jescheniak et al. (2003)

A. Caramazza, A. Costa, M. Miozzo, and Y. Bi (2001) reported a series of experiments showing that naming latencies for homophones are determined by specific-word frequency (e.g., frequency of nun) and not homophone frequency (frequency of nun + none). J. D. Jescheniak, A. S. Meyer, and W. J. M. Levelt (2003) have challenged these studies on a variety of grounds. Here we argue that these criticisms are not well founded and try to clarify the theoretical issues that can be meaningfully addressed by considering the effects of frequency on homophone production. We conclude that the evidence from homophone production cannot be considered to provide support to 2-layer theories of the lexical system.     

Does Hiv or Poverty Cause Aids? Biomedical and Epidemiological Perspectives

This paper contrasts biomedical and epidemiological approaches to the diagnosis and treatment of disease, and uses Collingwood's "principle of the relativity of causes" to show how different approaches focus on different causal factors reflecting different interests. By distinguishing between the etiology of a disease and an epidemic, the paper argues that, from an epidemiological perspective, poverty is an important causal factor in the African AIDS epidemic and that emphasizing this should not be considered incompatible with recognizing the causal necessity of HIV for the AIDS disease.