The study of socioethical issues in systems biology

Systems biology is the rapidly growing and heavily funded successor science to genomics. Its mission is to integrate extensive bodies of molecular data into a detailed mathematical understanding of all life processes, with an ultimate view to their prediction and control. Despite its high profile and widespread practice, there has so far been almost no bioethical attention paid to systems biology and its potential social consequences. We outline some of systems biology's most important socioethical issues by contrasting the concept of systems as dynamic processes against the common static interpretation of genomes. New issues arise around systems biology's capacities for in silico testing, changing cultural understandings of life, synthetic biology, and commercialization. We advocate an interdisciplinary and interactive approach that integrates social and philosophical analysis and engages closely with the science. Overall, we argue that systems biology socioethics could stimulate new ways of thinking about socioethical studies of life sciences.     

The Philosophical Case for Open Theism

The goal of this paper is to defend open theism vis-à-vis its main competitors within the family of broadly classical theisms, namely, theological determinism and the various forms of non-open free-will theism, such as Molinism and Ockhamism. After isolating two core theses over which open theists and their opponents differ, I argue for the open theist position on both points. Specifically, I argue against theological determinists that there are future contingents. And I argue against non-open free-will theists that future contingency is incompatible with the future’s being epistemically settled for God. This paper is a follow-up to the author’s Rhoda (Religious Studies, 2008) which was delivered during the APA Pacific 2007 Mini-Conference on Models of God.     

Sequelae of Aggression in Acutely Suicidal Adolescents

The consequences of aggression on problem course and suicide risk were examined in 270 acutely suicidal adolescents (ages 12-17 years; 184 girls). Participants were assessed during psychiatric hospitalization (T1), 6-months post-hospitalization (T2), and 15 or more months post-hospitalization (T3). Study variables included self- and parent-reported aggression; self-reported internalizing symptoms, suicidal ideation, suicide attempt, and adverse events; and clinician-rated suicidal behavior. Aggression was not directly related to suicide attempt concurrently or prospectively. However, among more aggressive youth, internalizing symptoms were more predictive of T3 suicide attempt than among less aggressive youth. T1 aggression predicted aggressive incidents and the likelihood of incarceration prior to T3. Two-level hierarchical linear modeling indicated that self-reported aggression and internalizing problems were linked in terms of severity and rates of decline over time. Overall, parent-reported aggression was negatively associated with suicidal ideation. Findings highlight (a) the continuity and consequences of aggression, (b) a possible role of aggression in worsening suicide risk factors and potentiating suicide attempt, and (c) the importance of ongoing research on subtypes of suicidal adolescents.     

Sectioned offenders presenting with enduring mental illness: a study exploring behaviors indicative of bullying

Logit and logistic regression analyses were employed to explore the nature, extent and predictors of behaviors indicative of "being bullied" and of "bullying others" in a sample of 125 adult male offender-patients sectioned for enduring mental illness and detained within a high-secure psychiatric hospital. The study addresses the lack of research into this specialized population to date, with a subsidiary aim of comparing the results directly with a previous study conducted with a population of adult male personality-disordered offender-patients (n = 53). Participants were required to complete a self-report behavioral checklist (Direct and Indirect Patient behavior Checklist-Hospital version Revised). The prediction that indirect (subtle) aggression would be reported more frequently than direct aggression was supported in relation to perpetration estimates, with evidence such aggression was also more prevalent among personality-disordered than mentally ill offender-patients. As predicted verbal aggression was the most commonly reported direct behavior. Although it was predicted that those perpetrating aggression would present with increased experience with secure settings this was only supported with regard to bully-victims. Contrary to the prediction made, those victimized did not present with less experience of secure settings. Consistent with the hypothesis, bully/victims were predicted by increased negative behavior toward staff and hospital rules. The results are discussed in relation to the environment in which the aggression is taking place with the implications for practice and future research outlined.     

Pigeons and people select efficient routes when solving a one-way "traveling salesperson" task

The authors presented people (Experiment 1) and pigeons (Experiments 2 and 3) with a large number of 1-way traveling salesperson problems that consisted of 3, 4, and 5 identical stimuli (nodes) on a computer monitor. The sequence of nodes that each traveler selected was recorded, and the distance of the route was subsequently determined. The routes the pigeons and people selected were reliably more efficient than those used by a Monte Carlo model given the same problems. The pigeons' routes were significantly less efficient than a nearest neighbor model of performance, however. In Experiment 3, pigeons were required to select a route that was within the top 33% of all possible solutions for a given problem. The pigeons' solutions were significantly more efficient than those observed in Experiment 2, in which the behavioral criterion was not imposed. The mechanisms that pigeons and people may have been using to solve the traveling salesperson problems are discussed.     

Helping to improve the group stereotype: on the strategic dimension of prosocial behavior

Three studies consider a basis for intergroup helping. Specifically, they show that group members may help others to disconfirm a stereotype of their own group as mean. Study 1 shows that Scots believe they are seen as mean by the English, resent this stereotype, are motivated to refute it, and believe out-group helping is a particularly effective way of doing so. Study 2 shows that increasing the salience of the English stereotype of the Scottish as mean leads Scots to accentuate the extent to which Scots are depicted as generous. Study 3 shows that increasing the salience of the stereotype of the Scots as mean results in an increase in the help volunteered to out-group members. These results highlight how strategic concerns may result in out-group helping. In turn, they underscore the point that helping others may be a means to advance a group's interest.     

Do people brace sensibly? Risk judgments and event likelihood

Previous research has shown that people become pessimistic about potentially bad news to "brace for the worst." Three studies examined whether people brace differently for rare and common negative events. Results reveal that people brace more for rare negative events than for common negative events (Studies 1-3a), but only when the event is self-relevant (Study 3b). Results also show that people brace more for rare events when feedback is imminent (Study 1), when negative outcomes are salient (Study 2), and when the outcomes are important or consequential (Study 3a). The authors discuss several possible explanations for the findings, including ignorance of the base rate, random responding, and anchoring and adjustment, and ultimately suggest that people may brace "enough."     

One-shot illusory correlations and stereotype formation

In four studies, the authors explored the emergence of one-shot illusory correlations--in which a single instance of unusual behavior by a member of a rare group is sufficient to create an association between group and behavior. In Studies 1, 2, and 3, unusual behaviors committed by members of rare groups were processed differently than other types of behaviors. They received more processing time, prompted more attributional thinking, and were more memorable. In Study 4, the authors obtained evidence from two implicit measures of association that one-shot illusory correlations are generalized to other members of a rare group. The authors contend that one-shot illusory correlations arise because unusual pairings of behaviors and groups uniquely prompt people to entertain group membership as an explanation of the unusual behavior.