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211.
Rivkin A Alexander RC Knighton J Hutson PH Wang XJ Snavely DB Rosah T Watt AP Reimherr FW Adler LA 《Journal of attention disorders》2012,16(8):664-674
Objective: Preclinical models, receptor localization, and genetic linkage data support the role of D4 receptors in the etiology of ADHD. This proof-of-concept study was designed to evaluate MK-0929, a selective D4 receptor antagonist as treatment for adult ADHD. Method: A randomized, double-blind, placebo-controlled, crossover study was conducted in adults with primary ADHD. The primary end point was changed from baseline in total score on the Adult ADHD Investigator Symptom Rating Scale following a 4-week treatment regimen. Additional measures included Clinical Global Impression-Severity Scale, Hospital Anxiety and Depression Scale, and Brown Attention Deficit Disorder Scale and D4 genotype analysis. Results: No statistically significant treatment differences were found between MK-0929 and placebo in any of the primary or secondary assessments. Conclusion: Results from this study suggest that blockade of the D4 receptor alone is not efficacious in the treatment of adult ADHD. 相似文献
212.
Hartley AA Maquestiaux F Brooks RD Festini SB Frazier K 《Cognitive, affective & behavioral neuroscience》2012,12(3):543-556
There is a response selection bottleneck that is responsible for dual-task interference. How the response selection bottleneck operates was addressed in three dual-task experiments. The overlap between two tasks (as indexed by the stimulus onset asynchrony [SOA]) was systematically manipulated, and both reaction time and electrodermal activity were measured. In addition, each experiment also manipulated some aspect of the difficulty of either task. Both increasing task overlap by reducing SOA and increasing the difficulty of either task lengthened reaction times. Electrodermal response was strongly affected by task difficulty but was only weakly affected by SOA, and in a different manner from reaction time. A fourth experiment found that the subjectively perceived difficulty of a dual-task trial was affected both by task difficulty and by SOA, but in different ways than electrodermal activity. Overall, the results were not consistent with a response selection bottleneck that involves processes of voluntary, executive attention. Instead, the results converge with findings from neural network modeling to suggest that the delay of one task while another is being processed reflects the operation of a routing mechanism that can process only one stream of information for action at a time and of a passive, structural store that temporarily holds information for the delayed task. The results suggest that conventional blocked or event-related neuroimaging designs may be inadequate to identify the mechanism of operation of the response selection bottleneck. 相似文献
213.
Kemeny ME Foltz C Cavanagh JF Cullen M Giese-Davis J Jennings P Rosenberg EL Gillath O Shaver PR Wallace BA Ekman P 《Emotion (Washington, D.C.)》2012,12(2):338-350
Contemplative practices are believed to alleviate psychological problems, cultivate prosocial behavior and promote self-awareness. In addition, psychological science has developed tools and models for understanding the mind and promoting well-being. Additional effort is needed to combine frameworks and techniques from these traditions to improve emotional experience and socioemotional behavior. An 8-week intensive (42 hr) meditation/emotion regulation training intervention was designed by experts in contemplative traditions and emotion science to reduce "destructive enactment of emotions" and enhance prosocial responses. Participants were 82 healthy female schoolteachers who were randomly assigned to a training group or a wait-list control group, and assessed preassessment, postassessment, and 5 months after training completion. Assessments included self-reports and experimental tasks to capture changes in emotional behavior. The training group reported reduced trait negative affect, rumination, depression, and anxiety, and increased trait positive affect and mindfulness compared to the control group. On a series of behavioral tasks, the training increased recognition of emotions in others (Micro-Expression Training Tool), protected trainees from some of the psychophysiological effects of an experimental threat to self (Trier Social Stress Test; TSST), appeared to activate cognitive networks associated with compassion (lexical decision procedure), and affected hostile behavior in the Marital Interaction Task. Most effects at postassessment that were examined at follow-up were maintained (excluding positive affect, TSST rumination, and respiratory sinus arrhythmia recovery). Findings suggest that increased awareness of mental processes can influence emotional behavior, and they support the benefit of integrating contemplative theories/practices with psychological models and methods of emotion regulation. 相似文献
214.
The impact of trait anxiety and perceptual load on selective attention was examined in a fear conditioning paradigm. A fear-conditioned angry face (CS+), an unconditioned angry face (CS-), or an unconditioned face with a neutral or happy expression were used in distractor interference and attentional probe tasks. In Experiments 1 and 2, participants classified centrally presented letters under two conditions of perceptual load. When perceptual load was high, distractors had no effect on selective attention, even with aversive conditioning. However, when perceptual load was low, strong response interference effects for CS+ face distractors were found for low trait-anxious participants. Across both experiments, this enhanced distractor interference reversed to strong facilitation effects for those reporting high trait anxiety. Thus, high trait-anxious participants were faster, rather than slower, when ignoring CS+ distractors. Using an attentional probe task in Experiment 3, it was found that fear conditioning resulted in strong attentional avoidance in a high trait-anxious group, which contrasted with enhanced vigilance in a low trait-anxious group. These results demonstrate that the impact of fear conditioning on attention is modulated by individual variation in trait anxiety when perceptual load is low. Fear conditioning elicits an avoidance of threat-relevant stimuli in high trait-anxious participants. 相似文献
215.
Alan Levinovitz 《Dao》2012,11(4):479-496
You ?[ is a crucial term for understanding the Zhuangzi. Translated as ??play,?? ??free play,?? and ??wandering,?? it is usually defined as an ideal, playful Zhuangzian way of being. There are two problems with this definition. The first is logical: the Zhuangzi cannot consistently recommend playfulness as an ideal, since doing so vitiates the essence of you??it becomes an ethical imperative instead of an activity freely undertaken for its own sake. The second problem is performative: arguments for playful Zhuangzi as exemplar resemble those of the logicians and philosophers who appear to come in for Zhuangzian criticism. This essay addresses these tensions by demonstrating how the Zhuangzi ambiguates the nature and value of you. Apparent endorsements of you are not freestanding, instead occurring in grudging replies of teachers to overly zealous students. In light of this recontextualization, a new version of you is offered that accommodates ??non-playful?? ways of being. 相似文献
216.
Perkins AM Inchley-Mort SL Pickering AD Corr PJ Burgess AP 《Journal of personality and social psychology》2012,102(5):910-924
Anxiety and fear are often confounded in discussions of human emotions. However, studies of rodent defensive reactions under naturalistic conditions suggest anxiety is functionally distinct from fear. Unambiguous threats, such as predators, elicit flight from rodents (if an escape-route is available), whereas ambiguous threats (e.g., the odor of a predator) elicit risk assessment behavior, which is associated with anxiety as it is preferentially modulated by anti-anxiety drugs. However, without human evidence, it would be premature to assume that rodent-based psychological models are valid for humans. We tested the human validity of the risk assessment explanation for anxiety by presenting 8 volunteers with emotive scenarios and asking them to pose facial expressions. Photographs and videos of these expressions were shown to 40 participants who matched them to the scenarios and labeled each expression. Scenarios describing ambiguous threats were preferentially matched to the facial expression posed in response to the same scenario type. This expression consisted of two plausible environmental-scanning behaviors (eye darts and head swivels) and was labeled as anxiety, not fear. The facial expression elicited by unambiguous threat scenarios was labeled as fear. The emotion labels generated were then presented to another 18 participants who matched them back to photographs of the facial expressions. This back-matching of labels to faces also linked anxiety to the environmental-scanning face rather than fear face. Results therefore suggest that anxiety produces a distinct facial expression and that it has adaptive value in situations that are ambiguously threatening, supporting a functional, risk-assessing explanation for human anxiety. 相似文献
217.
397 students arriving to take an exam in a junior level Principles of Management course were clearly warned on several occasions to keep cell phones outside the testing area or receive a failing test grade if the policy was violated. Just before the examination was administered, with all students sitting in their assigned seats, the professor made a final announcement that anyone still in possession of a cell phone would have one last opportunity to come forward and place it in a box at the front of the testing room. After eight students accepted this final "opportunity," the professor produced a hand-held metal detector, demonstrated how it could detect cell phones placed inside clothing, and informed the class that random screening of students would be conducted as they handed in their examinations. He then added that, as a special favor, he would allow a two-minute amnesty period during which any student could bring a cell phone to the front of the room for storage during the test. 38 students responded by turning in cell phones they had retained in direct violation of course policy. Implications of this cell phone dishonesty for creating viable business ethics and the role of perceived entitlement in shaping the behavior of these future business leaders were discussed. 相似文献
218.
Alan Millar 《Synthese》2012,189(2):353-372
Arguments for scepticism about perceptual knowledge are often said to have intuitively plausible premises. In this discussion I question this view in relation to an argument from ignorance and argue that the supposed persuasiveness of the argument depends on debatable background assumptions about knowledge or justification. A reasonable response to scepticism has to show there is a plausible epistemological perspective that can make sense of our having perceptual knowledge. I present such a perspective. In order give a more satisfying response to scepticism, we need also to consider the standing of background beliefs. This is required since the recognitional abilities that enable us to have perceptual knowledge are informed by, or presuppose, a picture or conception of the world the correctness of which we have not ascertained. The question is how, in the face of this, to make sense of responsible belief-formation. In addressing this problem I make a suggestion about the standing of certain crucial beliefs linking appearances with membership of kinds. 相似文献
219.
We argue that indeterminate probabilities are not only rationally permissible for a Bayesian agent, but they may even be rationally required. Our first argument begins by assuming a version of interpretivism: your mental state is the set of probability and utility functions that rationalize your behavioral dispositions as well as possible. This set may consist of multiple probability functions. Then according to interpretivism, this makes it the case that your credal state is indeterminate. Our second argument begins with our describing a world that plausibly has indeterminate chances. Rationality requires a certain alignment of your credences with corresponding hypotheses about the chances. Thus, if you hypothesize the chances to be indeterminate, your will inherit their indeterminacy in your corresponding credences. Our third argument is motivated by a dilemma. Epistemic rationality requires you to stay open-minded about contingent matters about which your evidence has not definitively legislated. Practical rationality requires you to be able to act decisively at least sometimes. These requirements can conflict with each other-for thanks to your open-mindedness, some of your options may have undefined expected utility, and if you are choosing among them, decision theory has no advice to give you. Such an option is playing Nover and Hájek??s Pasadena Game, and indeed any option for which there is a positive probability of playing the Pasadena Game. You can serve both masters, epistemic rationality and practical rationality, with an indeterminate credence to the prospect of playing the Pasadena game. You serve epistemic rationality by making your upper probability positive-it ensures that you are open-minded. You serve practical rationality by making your lower probability 0-it provides guidance to your decision-making. No sharp credence could do both. 相似文献
220.
Laidlaw KE Risko EF Kingstone A 《Journal of experimental psychology. Human perception and performance》2012,38(5):1132-1143
People tend to look at other people's eyes, but whether this bias is automatic or volitional is unclear. To discriminate between these two possibilities, we used a "don't look" (DL) paradigm. Participants looked at a series of upright or inverted faces, and were asked either to freely view the faces or to avoid looking at the eyes, or as a control, the mouth. As previously demonstrated, participants showed a bias to attend to both eyes and mouths during free viewing. In the DL condition, participants told to avoid the eyes of upright faces were unable to fully suppress the tendency to fixate on the faces' eyes, whereas participants told to avoid the mouth of upright faces successfully eliminated their bias to overtly attend to that feature. When faces were inverted, participants were equally able to suppress looks to the eyes and mouth. Together, these results suggest that the tendency to look at the eyes reflects orienting that is both volitional and automatic, and that the engagement of holistic or configural face processing mechanisms during upright face viewing has an influence in guiding gaze automatically to the eyes. (PsycINFO Database Record (c) 2012 APA, all rights reserved). 相似文献