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21.
Viviana Giannuzzi Annagrazia Altavilla Lucia Ruggieri Adriana Ceci 《Science and engineering ethics》2016,22(2):451-466
The European framework surrounding clinical trials on medicinal products for human use is going to change as demonstrated by the large debate at European institutional level. One of the major challenges is to overcome the lack of harmonisation of clinical trial procedures among countries. This aspect is gaining more and more importance, considering the increasing number of multicentre and multinational studies. In this work, the actual European rules governing the Clinical Trial Application have been analysed throughout the different steps including the registration of the trial in the European database; the preparation of documents to be submitted and their contents; the preparation of documents related to the information and consent process; the submission to competent bodies. Specific issues related to paediatric research and trials involving non EU/EEA countries have been addressed as well. Results reveal that the European legislation offers a well defined set of European rules covering different aspects of a Clinical Trial Application. However, these are not suitable to meet the challenges from multicentre and multinational clinical studies. A stronger set of rules, such as is available in a composite European Regulation has been adopted and is expected to harmonise practices and enable sponsors to carry out well conducted trials. But will the new regulation overcome the existing criticisms of Directive 2001/20/EC? 相似文献
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Maria Adriana Neroni Nadia Gamboz Stefania de Vito Maria Antonella Brandimonte 《Quarterly journal of experimental psychology (2006)》2016,69(9):1799-1811
Most experimental studies of prospection focused on episodic forms of future events prompted by means of verbal cues. However, there is evidence suggesting that future events differ considerably according to whether they are produced in response to external, experimenter-provided verbal cues or they are self-generated. In the present study, we compared the quality, the phenomenal characteristics, the temporal distribution, and the content of imagined events prompted by experimenter-provided cues (i.e., cue-words and short verbal sentences) or elicited by means of verbal cues that were self-generated in an autobiographical fluency task. The results showed that future events prompted by means of self-generated cues contained fewer event-specific details than future events prompted by experimenter-provided cues. However, future events elicited by means of self-generated and by experimenter-provided cues did not differ with respect to their phenomenal characteristics. The temporal distribution and the thematic content of future representations were also affected by the type of cue used to elicit prospection. These results offer a holistic view of the properties of future thinking and suggest that the content and the characteristics of envisioned future events may be affected by the method used to elicit prospection. 相似文献
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Recently researchers have begun examining the benefit of religious faith on mental and physical health outcomes. This study examined the relationship between religious faith and psychological functioning in 342 university students in diverse educational and geographic settings including a private West Coast Catholic college (sample 1), a Southern public state university (sample 2), and a Southern private Baptist college (sample 3). Participants completed several self-report measures. Strength of religious faith was significantly associated with optimism and experiencing meaning in life among sample 1. Results from sample 2 suggest that strength of religious faith was significantly associated with coping with stress, optimism, experiencing meaning in life, viewing life as a positive challenge, and low anxiety. Strength of religious faith was significantly associated with viewing life as a positive challenge and self-acceptance among sample 3. Although modest correlations surfaced, results suggest that strength of religious faith is associated with several important positive mental health benefits among college students. 相似文献
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The aim of this paper is to describe The Clinical Interview for Parents during Pregnancy (CGG—Colloquio per Genitori in Gravidanza). The interview was developed in the context of a longitudinal research study, carried out in the first 2 years of the child's life. The study was aimed at investigating fathers' attitudes and behavior toward child care and the possible influence of these attitudes and behavior on the child's current and future development. This was also compared with mothers' attitudes and behaviors. This work provides the background rationale for the content of the CGG and the discussion of the interview. The CGG was administered to 90 middle-class Italian couples expecting their first baby, who were recruited from childbirth classes to participate in the study. The sample did not include women at risk during pregnancy. We chose to investigate three areas: couples' ability to foresee their own function after the child's birth; the activities they expected to share with their baby; their capacity to anticipate their child's physical and psychological characteristics. Responses were subjected to quantitative content analysis. We describe the utility of such analysis. Finally, we review clinical and research meanings and applications of the CGG. © 1997 Michigan Association for Infant Mental Health 相似文献
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Philosophia - Several contemporary philosophical theories of introspection have been offered, yet each faces a number of difficulties in providing an explanation of the exact nature of... 相似文献
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Ana A. C. Osório Natália F. Rossi Óscar F. Gonçalves Adriana Sampaio Célia M. Giacheti 《Child neuropsychology》2017,23(6):631-641
Several studies have documented the high prevalence of psychopathology and behavior problems in Williams syndrome (WS). However, the links between cognitive development and such symptoms need further clarification. Our study aims to expand current knowledge on levels of behavior problems and its links to cognition in a sample of Brazilian individuals with WS. A total of 25 children and adolescents with WS and their parents participated in this study. The participants’ IQs were assessed with the Wechsler Scales of Intelligence (for children or adults) and parental reports of psychopathology/behavior problems were collected using the Child Behavior Checklist (CBCL). The presence of clinically significant attention problems was a main feature in our sample of children and adolescents with WS. In the children, higher IQ scores were found to be significantly associated with less externalizing problems, while in the adolescents cognitive abilities were found to be associated with less internalizing symptoms. These results provide further insight into the links between psychopathology and behavior problems and cognitive abilities in WS, and suggest the need to take age into consideration when analyzing such relationships. 相似文献
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Weisskirch RS Kim SY Zamboanga BL Schwartz SJ Bersamin M Umaña-Taylor AJ 《Cultural diversity & ethnic minority psychology》2011,17(1):43-51
Children from immigrant families often translate communication for parents, a process known as language brokering (LB). LB begins in childhood, but may continue through emerging adulthood, even when individuals are in college. We surveyed 1,222 university students with two immigrant parents and compared non-language brokers, infrequent language brokers, and frequent language brokers on a variety of ethnic, cultural, and identity measures. Significant differences emerged for cultural heritage value orientation, ethnic identity, and dimensions of acculturation with frequent language brokers scoring highest, infrequent language brokers scoring in the middle, and non-language brokers scoring the lowest on these measures. There were no significant differences on acculturative stress among these three groups. These results suggest that LB experiences may contribute to the development of psychological assets for ethnic minority, emerging adults from immigrant families. 相似文献