The “simulation” of the facial expression of emotions in case of short and long stimulus duration. The effect of pre-motor cortex inhibition by rTMS

Embodied cognition model states that the “simulation process” is necessary to the recognition of emotional significance of face. The present research explored the contribution of frontal motor brain components (i.e. mainly premotor area) to embodied cognition by using rTMS stimulation, to produce a temporary disruption of this specific cortical site. Secondly, short and long stimulus duration conditions were included to verify the contribution of the “simulation process” in response to overt and covert emotional stimulus comprehension. Nineteen subjects were asked to detect emotion/no emotion (anger, fear, happiness, neutral) in these two experimental conditions, by using a backward masking procedure. Five-second rTMS (1 Hz) was delivered before the stimulus onset. False alarms (Fa) and RTs increased and Hits decreased when frontal premotor brain activity was disrupted, specifically in response to anger and fear, for both long and shortduration condition. Thus, the present results highlight the main role of the frontal motor system for emotion facial expression processing.     

After-effects of reinforcement magnitude: Dependence upon context

On a fixed-interval schedule with rat subjects the duration of the post-reinforcement pause was found to be an increasing function of the magnitude of the preceding reinforcer. This relationship was observed when two magnitudes were contrasted closely in time, but not when the subjects were trained on each magnitude until the establishment of stable responding. After the behaviour was stable, the effect of the magnitude of reinforcement re-emerged when 50% of the scheduled reinforcers were omitted. Thus, the positive relationship between the magnitude of reinforcement and the duration of the post-reinforcement pause depended on the context of presentation of a given magnitude.     

Temporal aspects of selective masking

In two experiments, rows of random letter sequences were presented for 100 ms and were patterned masked at varying delays after display offset. In Experiment I recall was probed by visual partial report cues, while auditory probes were employed in Experiment II. Compared to no-masking control conditions, the masking stimulus had a selective effect at the different positions of the rows. The masking stimulus produced the largest decrements in recall of letters from the centre positions of the displays but had a minimal effect on performance at either end of the rows. Furthermore, it was demonstrated that improvements in recall were limited to the centre positions of the rows at increased delays of mask. Subsidiary analyses revealed that processing of the end letters of the displays terminates shortly after display offset while processing of the centre letters continues for at least 500 ms. The results are consistent with the notion that processing of multi-letter arrays commences at the ends of the rows and that the selective masking effect reflects the order of processing of the contents of iconic memory. However, these results were evident only in Experiment II which employed auditory partial report cues. When the partial report cues were visual, there were no effects of masking and minimal increases in performance at increased delays of mask. The discrepant results of the two experiments are discussed in terms of process interruption caused by obligatory attention to the partial report cues.     

Effects of signal uncertainty on statistical decisions

The experimental task involved statistical judgements about parameters of a random sample of dots displayed sequentially from a ‘signal’ or ‘noise’ distribution. Signal uncertainty was introduced by presenting small signal subsets of dots within larger observation sequences. Observer detection performance was adversely affected by this kind of signal uncertainty, but in the same way and to similar extent as that expected on the basis of ‘ideal’ and ‘independent’ statistical decision strategies.     

A Different Approach in Developing a Sexual Self-Concept Scale for Adolescents in Accra,Ghana

Adolescents residing in urban poor Accra face sexual and reproductive health challenges. Interventions to address them have not been entirely effective; thus, researching adolescents’ sexual self-concept (SSC) could strengthen our understanding of precursors to their sexual activity. For this study, a culturally appropriate scale is developed to measure the SSC of adolescents in urban poor Accra. Focus group discussions and content analysis generated items in the scale. Factor analyses techniques were used to develop sub-scales measuring different SSC dimensions. Three sub-scales, ‘sexual enthusiasm’, ‘sexual intrepidness’ and ‘sexual readiness’ were reliable SSC measures. Validity assessments found that sexually ready and enthusiastic youth were more likely to have engaged in coital, pre-coital and risky sexual behaviors. Also, as their sexual intrepidness and enthusiasm increased, adolescents had significantly worse mental health. These scales may provide an important step in understanding adolescent sexual behavior in the urban poor context and thus need further investigation.     

Clinical Trial Application in Europe: What Will Change with the New Regulation?

The European framework surrounding clinical trials on medicinal products for human use is going to change as demonstrated by the large debate at European institutional level. One of the major challenges is to overcome the lack of harmonisation of clinical trial procedures among countries. This aspect is gaining more and more importance, considering the increasing number of multicentre and multinational studies. In this work, the actual European rules governing the Clinical Trial Application have been analysed throughout the different steps including the registration of the trial in the European database; the preparation of documents to be submitted and their contents; the preparation of documents related to the information and consent process; the submission to competent bodies. Specific issues related to paediatric research and trials involving non EU/EEA countries have been addressed as well. Results reveal that the European legislation offers a well defined set of European rules covering different aspects of a Clinical Trial Application. However, these are not suitable to meet the challenges from multicentre and multinational clinical studies. A stronger set of rules, such as is available in a composite European Regulation has been adopted and is expected to harmonise practices and enable sponsors to carry out well conducted trials. But will the new regulation overcome the existing criticisms of Directive 2001/20/EC?     

Why Does Disaster Recovery Work Influence Mental Health?: Pathways through Physical Health and Household Income

Disaster recovery work increases risk for mental health problems, yet the mechanisms underlying this association are unclear. We explored links from recovery work to post‐traumatic stress (PTS), major depression (MD), and generalized anxiety disorder (GAD) symptoms through physical health symptoms and household income in the aftermath of the Deepwater Horizon oil spill. As part of the NIEHS GuLF STUDY, participants (N = 10,141) reported on cleanup work activities, spill‐related physical health symptoms, and household income at baseline, and mental health symptoms an average of 14.69 weeks (SD = 16.79) thereafter. Cleanup work participation was associated with higher physical health symptoms, which in turn were associated with higher PTS, MD, and GAD symptoms. Similar pattern of results were found in models including workers only and investigating the influence of longer work duration and higher work‐related oil exposure on mental health symptoms. In addition, longer worker duration and higher work‐related oil exposure were associated with higher household income, which in turn was associated with lower MD and GAD symptoms. These findings suggest that physical health symptoms contribute to workers’ risk for mental health symptoms, while higher household income, potentially from more extensive work, might mitigate risk.     

Effects of self-generated versus experimenter-provided cues on the representation of future events

Most experimental studies of prospection focused on episodic forms of future events prompted by means of verbal cues. However, there is evidence suggesting that future events differ considerably according to whether they are produced in response to external, experimenter-provided verbal cues or they are self-generated. In the present study, we compared the quality, the phenomenal characteristics, the temporal distribution, and the content of imagined events prompted by experimenter-provided cues (i.e., cue-words and short verbal sentences) or elicited by means of verbal cues that were self-generated in an autobiographical fluency task. The results showed that future events prompted by means of self-generated cues contained fewer event-specific details than future events prompted by experimenter-provided cues. However, future events elicited by means of self-generated and by experimenter-provided cues did not differ with respect to their phenomenal characteristics. The temporal distribution and the thematic content of future representations were also affected by the type of cue used to elicit prospection. These results offer a holistic view of the properties of future thinking and suggest that the content and the characteristics of envisioned future events may be affected by the method used to elicit prospection.