Effect of Short-Term Training on Reaching Behavior in Infants: A Randomized Controlled Clinical Trial

The purpose of this study was to test the effect of short-term training on reaching behavior in infants at the onset of reaching. The study was a single-blind, parallel group design, randomized controlled clinical trial. Thirty healthy infants were randomly assigned to a social control group (n = 15) or a reaching training group (n = 15). Infants began the study up to 3 days after the onset of reaching and were assessed three times across 2 days: pretraining (before training), posttraining 1 (after 1 session of training), and posttraining 2 (after 3 sessions of training). The reaching training group received 3 sessions of training by a physical therapist while the control group received a similar amount of time sitting in the therapist's lap. The data were analyzed using repeated-measures analyses of variance, and independent-samples tests with Bonferroni adjustments. Short-term training resulted in increased frequency of object contacts, shorter and smoother reaches, and improved hand positioning. The few short training sessions likely provided opportunities for infants to explore and learn to select movements from their existing movement repertoire. These results demonstrate that adaptive changes in infants' novel behaviors can emerge rapidly, and highlight the need for increased understanding of how to most effectively time early interventions.     

Sit-to-stand movement in children: A longitudinal study based on kinematics data

Although the ability to stand from a seated posture is relevant for clinical practice, there are few studies investigating the process of acquisition and refinement of the motor components involved in sit-to-stand movement (STS) in children. Therefore, this longitudinal study aims to describe kinematic characteristics of the STS movement in children from 12 to 18 months, and also to investigate the relationship between changes in STS movement and childrens’ daily-life mobility. Ten healthy children were evaluated at 12,13,14,15 and 18 months of age. A motion analysis system was used to measure total duration of STS movement and angular movements of each joint, and frequencies of successful and unsupported STS were obtained. The Pediatric Evaluation of Disability Inventory was used to assess childrens’ daily-life mobility. Results showed that children tend to increase the frequency of successful trials over the months by reducing the total duration and decreasing peak ankle dorsiflexion and trunk flexion during STS. Children also started to stand up from chair with decreased trunk flexion angle among ages. At the end of the STS, we observed decreases in trunk flexion and knee flexion over age. Furthermore, kinematic characteristics that reflect improvements in STS movement are related to better performance of functional skills and decreased level of assistance provided by the caregiver in daily-life mobility of younger children. However, the strength of these associations decreases from 14 months of age onwards.     

The “simulation” of the facial expression of emotions in case of short and long stimulus duration. The effect of pre-motor cortex inhibition by rTMS

Embodied cognition model states that the “simulation process” is necessary to the recognition of emotional significance of face. The present research explored the contribution of frontal motor brain components (i.e. mainly premotor area) to embodied cognition by using rTMS stimulation, to produce a temporary disruption of this specific cortical site. Secondly, short and long stimulus duration conditions were included to verify the contribution of the “simulation process” in response to overt and covert emotional stimulus comprehension. Nineteen subjects were asked to detect emotion/no emotion (anger, fear, happiness, neutral) in these two experimental conditions, by using a backward masking procedure. Five-second rTMS (1 Hz) was delivered before the stimulus onset. False alarms (Fa) and RTs increased and Hits decreased when frontal premotor brain activity was disrupted, specifically in response to anger and fear, for both long and shortduration condition. Thus, the present results highlight the main role of the frontal motor system for emotion facial expression processing.     

Self-Criticism and Depressive Symptoms Mediate the Relationship Between Emotional Experiences With Family and Peers and Self-Injury in Adolescence

Although the relationship between negative childhood experiences, peer victimization, depressive symptoms, and Non-Suicidal Self-Injury (NSSI) is widely recognized, the mechanisms involved are not fully understood, especially among adolescents. This study aims to test the mediating role of both self-criticism and depressive symptoms in the relationship between memories of negative or positive experiences, current peer victimization, and NSSI. The sample consists 854 Portuguese adolescents, 451 female and 403 male, with ages between 12 and 18 years (M = 14.89; SD = 1.79), from middle and secondary schools. Participants answered self-report measures. Results from path analysis showed that memories of negative experiences, the absence of positive memories with family in childhood and peer victimization indirectly impact on NSSI through self-criticism and depressive symptoms. In addition, these stressful experiences led to depressive symptoms through self-criticism. Lastly, the most severe form of self-criticism indirectly impacts on NSSI through depressive symptoms, even though it also has a strong direct effect. It suggests that negative experiences with parents and peer victimization, as well as the absence of positive memories with family, have a negative impact on NSSI when these experiences are linked with a sense of self-hatred and depressive symptoms.     

The Indirect Effect of Early Experiences on Deliberate Self-Harm in Adolescence: Mediation by Negative Emotional States and Moderation by Daily Peer Hassles

The present study examines whether early experiences of threat, subordination and devaluation with family influence adolescents’ negative emotional states and subsequently deliberate self-harm; and if this effect is conditioned by daily peer hassles. The sample consisted of 441 adolescents (57.6 % female) with ages between 13 and 18 years old from middle and high schools. Participants completed self-report instruments measuring early memories of threat, subordination and devaluation, daily peer hassles, negative affect and deliberate self-harm behaviors. Results from conditional process analysis showed that adolescents who feel devalued and experience threat and submission within family tend to endorse high levels of negative affect, which in turn accounts for increased endorsements on deliberate self-harm. Moreover, the impact of negative affect on deliberate self-harm is amplified by the presence of moderate and high levels of daily peer hassles. This study suggests the relevance of assessing and intervening on type of emotional memories (i.e., threat, subordination and devaluation), daily disruptions with peers and negative emotional states with adolescents who self-injure. These findings may be useful in the development of preventive and intervention programs for reducing deliberate self-harm in adolescence.     

A Different Approach in Developing a Sexual Self-Concept Scale for Adolescents in Accra,Ghana

Adolescents residing in urban poor Accra face sexual and reproductive health challenges. Interventions to address them have not been entirely effective; thus, researching adolescents’ sexual self-concept (SSC) could strengthen our understanding of precursors to their sexual activity. For this study, a culturally appropriate scale is developed to measure the SSC of adolescents in urban poor Accra. Focus group discussions and content analysis generated items in the scale. Factor analyses techniques were used to develop sub-scales measuring different SSC dimensions. Three sub-scales, ‘sexual enthusiasm’, ‘sexual intrepidness’ and ‘sexual readiness’ were reliable SSC measures. Validity assessments found that sexually ready and enthusiastic youth were more likely to have engaged in coital, pre-coital and risky sexual behaviors. Also, as their sexual intrepidness and enthusiasm increased, adolescents had significantly worse mental health. These scales may provide an important step in understanding adolescent sexual behavior in the urban poor context and thus need further investigation.     

Clinical Trial Application in Europe: What Will Change with the New Regulation?

The European framework surrounding clinical trials on medicinal products for human use is going to change as demonstrated by the large debate at European institutional level. One of the major challenges is to overcome the lack of harmonisation of clinical trial procedures among countries. This aspect is gaining more and more importance, considering the increasing number of multicentre and multinational studies. In this work, the actual European rules governing the Clinical Trial Application have been analysed throughout the different steps including the registration of the trial in the European database; the preparation of documents to be submitted and their contents; the preparation of documents related to the information and consent process; the submission to competent bodies. Specific issues related to paediatric research and trials involving non EU/EEA countries have been addressed as well. Results reveal that the European legislation offers a well defined set of European rules covering different aspects of a Clinical Trial Application. However, these are not suitable to meet the challenges from multicentre and multinational clinical studies. A stronger set of rules, such as is available in a composite European Regulation has been adopted and is expected to harmonise practices and enable sponsors to carry out well conducted trials. But will the new regulation overcome the existing criticisms of Directive 2001/20/EC?     

Effects of self-generated versus experimenter-provided cues on the representation of future events

Most experimental studies of prospection focused on episodic forms of future events prompted by means of verbal cues. However, there is evidence suggesting that future events differ considerably according to whether they are produced in response to external, experimenter-provided verbal cues or they are self-generated. In the present study, we compared the quality, the phenomenal characteristics, the temporal distribution, and the content of imagined events prompted by experimenter-provided cues (i.e., cue-words and short verbal sentences) or elicited by means of verbal cues that were self-generated in an autobiographical fluency task. The results showed that future events prompted by means of self-generated cues contained fewer event-specific details than future events prompted by experimenter-provided cues. However, future events elicited by means of self-generated and by experimenter-provided cues did not differ with respect to their phenomenal characteristics. The temporal distribution and the thematic content of future representations were also affected by the type of cue used to elicit prospection. These results offer a holistic view of the properties of future thinking and suggest that the content and the characteristics of envisioned future events may be affected by the method used to elicit prospection.     

A semistructured interview with parents-to-be used during pregnancy: Preliminary data

The aim of this paper is to describe The Clinical Interview for Parents during Pregnancy (CGG—Colloquio per Genitori in Gravidanza). The interview was developed in the context of a longitudinal research study, carried out in the first 2 years of the child's life. The study was aimed at investigating fathers' attitudes and behavior toward child care and the possible influence of these attitudes and behavior on the child's current and future development. This was also compared with mothers' attitudes and behaviors. This work provides the background rationale for the content of the CGG and the discussion of the interview. The CGG was administered to 90 middle-class Italian couples expecting their first baby, who were recruited from childbirth classes to participate in the study. The sample did not include women at risk during pregnancy. We chose to investigate three areas: couples' ability to foresee their own function after the child's birth; the activities they expected to share with their baby; their capacity to anticipate their child's physical and psychological characteristics. Responses were subjected to quantitative content analysis. We describe the utility of such analysis. Finally, we review clinical and research meanings and applications of the CGG. © 1997 Michigan Association for Infant Mental Health     

Modes of Introspective Access: a Pluralist Approach

Philosophia - Several contemporary philosophical theories of introspection have been offered, yet each faces a number of difficulties in providing an explanation of the exact nature of...