Biomagnetism from the neuropsychiatric viewpoint--principles of recent developments in diagnostic procedure

The following survey is intended to demonstrate and discuss some principle problems of biomagnetism and the application in clinical fields. The development of special technical parameters especially by the SQUID method is initiating new possibilities of research and completing the neurobiologically determinated basis and conditions of neuropsychiatric disorders. The Magnetoencephalography (MEG) will be represent an important role of a new functional diagnostic method.     

Infant hypotonia, obesity, hypogenitalism and oligophrenia--new viewpoints on the etiology and symptoms of Prader-Willi syndrome

We present four cases of Prader-Willi syndrome. Two of them have an abnormality of a chromosome 15, the other both show different chromosomal abnormalities. Translocations or deletions were found recently in the bands 15q11/12 in about 60% of the cases of Prader-Willi syndrome. The consequences for diagnosis, symptomatology and genetic counselling of the syndrome are discussed.     

Changes in self-stimulatory behaviors with treatment

For four of six autistic children who underwent intensive behavioral treatment, the nature of their self-stimulatory behavior changed from initial lowlevel motor behaviors (such as rocking, spinning, twirling) to differing kinds of higher-level behaviors (such as lining of objects, echolalic speech, and preoccupation with spelling and numerical values). The children who changed to the highest levels of self-stimulatory behavior also showed the largest gains in treatment (as determined by IQ scores, school placement, etc.). The changes in self-stimulatory behaviors were attributed to the intense teaching of appropriate social behaviors and the explicit therapeutic suppression of low-level, self-stimulatory behaviors. The long-term therapeutic effects of changing from lower-to higher-level forms of self-stimulatory behavior were discussed.This study was supported by a grant from the National Institute of Mental Health (grant MH 11440). We want to express our thanks to the parents who allowed us to study their children. We gratefully acknowledge the assistance of Maria Audero with the design of the weighted measure, and Tracee Parker with the collection of the data.     

The word-superiority effect under conditions that approximate reading

Observers detected a briefly flashed target letter embedded in word, pronounceable nonword, and unpronounceable nonword contexts. The word context facilitated perception under both holistic and analytical processing strategies; the facilitative effect was enhanced when processing was analytical.     

Contrast requirements for picture recognition: converging evidence for a spatial frequency hypothesis

Based upon perceptual studies, the present hypothesis was that different ranges of spatial-frequency information constitute different sources of information for recognition memory. In Experiment 1, 40 subjects were tested with sets of focused and unfocused pictures as inspection and test stimuli. In addition to reporting whether each test picture was believed to be a member of the inspection set or a novel picture, each subject was allowed to adjust the contrast of the stimulus until such a judgment could be made. In Experiment 2, subjects made similar judgments when inspection or test stimuli were flickered (perceptually enhancing low spatial frequencies) or unflickered. Results from both studies were consistent with the experimental hypothesis. Other studies were reviewed, which, together with the present data, lend converging evidence to the spatial-frequency hypothesis.     

Adolescent marijuana use: the role of the physician

Adolescent marijuana use is an issue of concern to the community at large. Physicians now have the technology to identify marijuana use and thus are in a unique position to deal with the issue. This article addresses the moral issues related to screening and surveillance of adolescent marijuana use and postulates the justification for active physician intervention.     

Neuroticism,Somatic Complaints,and Disease: Is the Bark Worse than the Bite?

Perhaps because negative emotions are frequently expressed in physiological reactions, psychosomatic theories have often identified Neuroticism and its component traits (including anxiety, anger, and depression) as causal influences on the development of disease. These views are apparently supported by correlations between physical symptom reports and measures of Neuroticism in males. Data from 347 adult women in the Baltimore Longitudinal Study of Aging replicate this finding for total physical complaints and for most body systems. However, analyses of mortality in the literature and in the present article show no influence of Neuroticism, suggesting that symptom reporting may be biased by Neuroticism-related styles of perceiving and reporting physiological experiences. Researchers in this area are urged to employ objective measures of medical status, and to be alert to possible biases of self-selection and selective perception in interpreting associations between Neuroticism and disease.     

Study of neuromotor reaction times under the influence of thyrotropin-releasing hormone

Neuromotor reaction times (simple, choice, and decision) were measured when Thyrotropin-releasing hormone (TRH) was administered intravenously to nine healthy men in a double-blind study. Measurements were made of simple reaction time, choice reaction time, and decision time for each subject at various intervals over a 54-hr. period. Given the observed inherent interaction of the drug with the long time used (54 hr.), most analyses were conducted across separate time epochs. Injected subjects showed inhibition in the normal improvement of simple reaction time (which occurs with practice), and they reduced the time required to make a decision. Choice reaction time, however, remained unchanged across the drug-nondrug experimental conditions.