Epigenetics in the mature mammalian brain: effects on behavior and synaptic transmission

The role of epigenetic mechanisms in control of gene expression during mammalian development is well established. Associations between specific DNA or histone modifications and numerous neurodevelopmental and neurodegenerative disorders implies significant consequences of epigenetic dysregulation in both the developing and mature brain, the latter of which is the general focus of this review. Accumulating evidence suggests that epigenetic changes are involved in normal cognitive processes in addition to neurological and psychiatric disorders. Recent investigations into the regulation of epigenetic modifications in the adult brain have revealed novel and surprisingly dynamic mechanisms for controlling learning and memory-related behaviors as well as long-term synaptic plasticity. DNA methylation and histone acetylation have also been implicated in the modulation of basal synaptic transmission and the balance between excitation and inhibition in various brain regions. Studies have begun to uncover some of the alterations in gene expression that appear to mediate many of these effects, but an understanding of the precise mechanisms involved is still lacking. Nevertheless, the fundamental importance of epigenetic processes in influencing neuronal activity is becoming increasingly evident.     

Maternal stress and perceptions of self-efficacy in socioeconomically disadvantaged mothers: an explicative model

Studies have demonstrated that maternal stress and perceptions of self-efficacy influence a mother's performance, affecting her ability to interact with her child and to understand and answer his needs. The purpose of this study was to evaluate maternal stress and the perception of self-efficacy in the mothers of infants who are cared for in child-care centers and belong to the poorest segment of the Chilean population. To this end, these aspects were studied in 121 low-income, high-social-risk mothers with children between the ages of 4 and 9 months. The final goal was to generate an explicative model of self-efficacy and maternal stress that considered characteristics of the family and the child. The results revealed that family characteristics - especially household size, per capita incomes and mother age - are more relevant for explaining maternal self-efficacy and stress. The findings and implications for practice are discussed.     

An open letter to institutional review boards considering Northfield Laboratories' PolyHeme® trial

At the time of this writing, a widely publicized, waived-consent trial is underway. Sponsored by Northfield Laboratories, Inc. (Evanston, IL) the trial is intended to evaluate the emergency use of PolyHeme?, an oxygen-carrying resuscitative fluid that might prevent deaths from uncontrolled bleeding. The protocol allows patients in hemorrhagic shock to be randomized between PolyHeme? and saline in the field and, still without consent, randomized between PolyHeme? and blood after arrival at an emergency department. The Federal regulations that govern the waiver of consent restrict its applicability to circumstances where proven, satisfactory treatments are unavailable. Blood-the standard treatment for hemorrhagic shock-is not available in ambulances but is available in hospitals. The authors argue that the in-hospital stage of the study fails to meet ethical and regulatory standards.     

Identity in Action: Predictors of Feminist Self-Identification and Collective Action

The present study sought to explore how women's life experiences influenced their beliefs, and how those beliefs in turn influenced feminist self-identification. Additionally, we sought to determine whether feminist self-identification led to increased collective action on behalf of women. Female participants (N?=?282) from two US college campuses and online listservs completed an online survey assessing feminist self-identification, collective action, and life experiences. Conservative, liberal, and radical beliefs were assessed as were evaluations of feminists. A structural equation model was used to explore these relationships; life experiences were found to influence women's beliefs, which in turn influenced feminist self-identification, which influenced collective action. We found that life experiences may serve as a catalyst for both feminist self-identification and collective action.     

Putting Values into Practice: Public Policy and the Future of Mental Health Consumer-run Organizations

The purpose of the paper is to reflect on value dilemmas in mental health consumer-run organizations and to discuss implications for research, policy, and practice. We review the roots of consumer-run organizations in the self-help movement and the psychiatric survivor liberation movement, focusing on the distinctive values espoused by consumer-run organizations. We also discuss evidence-based and value-based approaches to mental health policy formulation and mental health reform, noting the particular importance of value-based approaches and the role that consumer-run organizations can play in mental health reform. Based on our experiences conducting a participatory action research study of four mental health consumer-run organizations, we identify and examine several value dilemmas, discuss the lessons that we learned about these value dilemmas, and note their implications for future directions in research, policy, and practice.     

Intent Attributions and Aggression: A Study of Children and their Parents

This research aimed to further clarify the relationship between children's self-reported hostile intent attributions (for ambiguous instrumental or relational provocations) and peer-reported aggression (physical and relational) in 500 fourth-grade children. In addition, we examined whether parents' intent attributions might predict children's intent attributions and aggression. Both parents (mothers and fathers) in 393 families completed intent attribution questionnaires. Results showed, consistent with past research, that boys' instrumental intent attributions were related to physical aggression. Children's relational intent attributions, however, were not associated with relational aggression. Contrary to expectations, most children responded with hostile intent attributions for relational provocations. Finally, in regard to parent-child connections, maternal intent attributions correlated with children's intent attributions whereas paternal intent attributions corresponded with children's relational aggression.     

Evaluation of a Shortened South Oaks Gambling Screen in veterans with addictions.

Rates of pathological gambling have increased with the availability of legalized gambling. Substance-abuse units increasingly recognize the need to assess for gambling problems. The South Oaks Gambling Screen (SOGS; H. R. Lesieur & S. B. Blume, 1987) has filled this need. Previous research (M. Oehlert & K. Nelson, 2004) has considered the feasibility of reducing the length of the SOGS while maintaining its ability to identify people at risk for problematic gambling. In this study, the authors examined the utility of a shortened SOGS (SSOGS) in a 2nd sample of veterans with addictions. The authors used data analysis to explore SSOGS psychometric properties and to provide additional support for use of the shorter instrument.     

Can CBT Be Effective for Aboriginal Australians? Perspectives of Aboriginal Practitioners Trained in CBT

The objective of the study was to investigate whether high and low intensity versions of cognitive behaviour therapy (CBT) might be an effective therapeutic approach for enhancing the mental health of Aboriginal Australians. Five university‐educated Aboriginal counsellors received in‐depth training in CBT. Over the following year, they used CBT strategies with their clients, and met 10 times as a participatory action research group. The group addressed three key questions: (a) Does CBT appear to be useful for Aboriginal Australians? (b) If so, what elements of CBT are perceived to be effective? (c) What adaptations might be made to CBT to enhance its effectiveness with Aboriginal Australians? The resulting qualitative data were transcribed and analysed. Counsellors perceived CBT to be very useful for their Aboriginal clients and for themselves. They reported that it enhanced their clients' well‐being, their own clinical skills, and their own well‐being, and it reduced burnout. The qualities of CBT that were perceived to be effective were its adaptability, pragmatic here‐and‐now approach, capacity for low‐intensity interventions, safe containing structure, promotion of self‐agency, and valuable techniques. It was suggested that the prime requirement for adaptations to CBT were that they would need to fit different social and cultural contexts.     

Thinking of Others: Feminist Identification and the Perception of Others’ Beliefs

Previous research has shown that most women in the United States support feminist goals but do not label themselves as feminists. Concern over other people’s opinions of feminists may predict rejection of the feminist label. In the present study we predicted that feminists would be more likely than non-feminists to believe that other people view feminists favorably. One hundred seventy-one female participants completed the Berryman-Fink Semantic Differential Scale twice, once to indicate how they view feminists and again to indicate how they believe others view feminists. Contrary to our hypothesis, all women, regardless of feminist identification, believed that others view feminists negatively and as more likely to be homosexual than heterosexual. Relationships between participants’ own views of feminists and their perceptions of others’ views of feminists were explored. Transformative experiences that may lead a feminist to ignore their perception of society’s views are discussed.