Effects of pharmacological manipulations of NMDA-receptors on deliberation in the Multiple-T task

Both humans and non-human animals have the ability to navigate and make decisions within complex environments. This ability is largely dependent upon learning and memory processes, many of which are known to depend on NMDA-sensitive receptors. When humans come to difficult decisions they often pause to deliberate over their choices. Similarly, rats pause at difficult choice points. This behavior, known as vicarious trial and error (VTE), is hippocampally dependent and entails neurophysiological representations of expectations of future outcomes in hippocampus and downstream structures. In order to determine the dependence of VTE behaviors on NMDA-sensitive receptors, we tested rats on a Multiple-T choice task with a reward-delivery reversal known to elicit VTE. Rats under the influence of NMDA-receptor antagonists (CPP) showed a significant reduction in VTE, particularly at the reward reversal, implying a role for NMDA-sensitive receptors in the generation of vicarious trial and error behaviors.     

Humanizing Personhood

This paper explores the debate between personists, who argue that the concept of a person if of central importance for moral thought, and personists, who argue that the concept of a human being is of greater moral significance. On the one hand, it argues that normative naturalism, the most ambitious defense of the humanist position, fails to identify moral standards with standards of human behavior and thereby fails to undermine the moral significance of personhood. At the same time, it contends that a more focused attention on the morally relevant features of human life may indeed play a crucial role in enhancing our moral understanding.     

Cognitive-behavioral therapy of insomnia: A clinical case series study of patients with co-morbid disorders and using hypnotic medications

Cognitive-behavioral therapy for insomnia (CBTi) has demonstrated considerable efficacy within randomized clinical trials and case-series designs. This case-series study in a community sleep medicine clinic assessed the effectiveness of an eight-session CBTi protocol chronic insomnia patients who were allowed to continue their use of hypnotics (intent-to-treat n = 48), administered by a clinical psychology doctoral student receiving training and supervision in CBTi by a behavioral sleep medicine certified clinician. Outcome measures included daily sleep diaries, self-report measures on insomnia severity, dysfunctional beliefs and attitudes about sleep, daytime sleepiness, as well as medication usage. Patients showed significant improvements in sleep onset latency, wake time after sleep onset, sleep efficiency, insomnia severity, and dysfunctional sleep beliefs from pre- to post-treatment. No changes were seen in daytime sleepiness - patients were not excessively sleepy either before or after treatment. Use of sleep medication declined significantly from 87.5% pre-treatment to 54% post-treatment, despite no active efforts to encourage patients to withdraw. Results demonstrate that a CBTi conducted in a community sleep medicine clinic with patients not required to discontinue sleep-related medications can have similar effects as therapy delivered among those not on medication.     

Perception through a perspective-taking lens: Differential effects on judgment and behavior

In contrast to the view that social perception has symmetric effects on judgments and behavior, the current research explored whether perspective-taking leads stereotypes to differentially affect judgments and behavior. Across three studies, perspective-takers consistently used stereotypes more in their own behavior while simultaneously using them less in their judgments of others. After writing about an African-American, perspective-taking tendencies were positively correlated with aggressive behavior but negatively correlated with judging others as aggressive. Similarly, after writing about an elderly man, perspective-takers walked more slowly and became more conservative, but judged others as less dependent. These divergent effects of perspective-taking on judgment and behavior occurred regardless of whether perspective-taking was manipulated or measured, whether judgments were measured before or after behavior, the stereotype that was activated, and participants’ culture (American, Singaporean). These findings support theorizing that judgments and behavior can diverge when individuals’ social strategies are geared towards establishing and maintaining social bonds, as well as provide insight into how perspective-taking helps individuals manage diversity.     

The role of comorbid disruptive behavior in the clinical expression of pediatric obsessive-compulsive disorder

This study explored the impact of disruptive behavior disorder (DBD) comorbidity on a number of theoretically relevant outcomes among 192 children and adolescents with obsessive-compulsive disorder (OCD). Youth were divided into three groups: OCD Only, OCD+DBD comorbidity and OCD+Other comorbidity. Relative to those without a comorbid condition and those with any non-DBD comorbidity, comorbid DBD was associated with greater family accommodation and less symptom resistance. Youth with comorbid DBD exhibited greater OCD symptom severity, OCD-related impairment, anxiety, and internalizing problems than those with no comorbidity. Those with comorbid DBD were over 3.6 times as likely to be taking an atypical antipsychotic medication relative to children without comorbidity. The present results suggest that comorbid DBD contributes to more severe illness presentation above and beyond an OCD diagnosis alone, and may be associated with differing pharmacotherapy prescribing practices.     

Psychometric Properties of the Anticipatory Social Behaviours Questionnaire

Relative to other components of Clark and Wells’ (1995) model, anticipatory processing has been understudied, despite research that suggests that anticipatory processing may maintain social anxiety through mechanisms such as increased anxiety, negative memory biases, and other negative consequences. Anticipatory processing has only been examined as a unitary process, with no efforts examining the underlying structure of this process. The purpose of the current study was to examine the factor structure of the Anticipatory Social Behaviours Questionnaire (ASBQ, Hinrichsen and Clark Journal of Behavior Therapy and Experimental Psychiatry, 34, 205–218, 2003) and identify relationships between the measure’s factors and other constructs of social anxiety. Study 1 (N?=?861) used exploratory factor analysis and concluded that a two-factor model (Avoidance and Preparation) was the best conceptualization of anticipatory processing. Study 2 confirmed the two factor model in a separate sample (N?=?485) and demonstrated the superiority of the two-factor model over a unitary model. Results of Study 3 suggested that, with a sample of high-socially-anxious undergraduates (N?=?59), the Avoidance factor was more maladaptive than the Preparation factor. Results are discussed in the context of the anticipatory processing literature and future directions are proposed.     

Does response mode affect amount recalled or the magnitude of the testing effect?

The testing effect is the finding that retrieval practice can enhance recall on future tests. One unanswered question is whether first-test response mode (writing or speaking the answer) affects final-test performance (and whether final-test response mode itself matters). An additional unsettled issue is whether written and oral recall lead to differences in the amount recalled. In three experiments, we examined these issues: whether subjects can recall more via typing or speaking; whether typing or speaking answers on a first test can lead to better final-test performance (and whether an interaction occurs with final-test response mode) and whether any form of overt response leads to better final-test performance as compared to covert retrieval (thinking of the answer but not producing it). Subjects studied paired associates; took a first test by typing, speaking, or thinking about responses; and then took a second test in which the answers were either spoken or typed. The results revealed few differences between typing and speaking during recall, and no difference in the size of the testing effect on the second test. Furthermore, an initial covert retrieval yielded roughly the same benefit to future test performance as did overt retrieval. Thus, the testing effect was quite robust across these manipulations. The practical implication for learning is that covert retrieval provides as much benefit to later retention as does overt retrieval and that both can be effective study strategies.     

Armed and attentive: Holding a weapon can bias attentional priorities in scene viewing

The action-specific perception hypothesis (Witt, Current Directions in Psychological Science 20: 201–206, 2011) claims that the environment is represented with respect to potential interactions for objects present within said environment. This investigation sought to extend the hypothesis beyond perceptual mechanisms and assess whether action-specific potential could alter attentional allocation. To do so, we examined a well-replicated attention bias in the weapon focus effect (Loftus, Loftus, & Messo, Law and Human Behaviour 1, 55–62, 1987), which represents the tendency for observers to attend more to weapons than to neutral objects. Our key manipulation altered the anticipated action-specific potential of observers by providing them a firearm while they freely viewed scenes with and without weapons present. We replicated the original weapon focus effect using modern eye tracking and confirmed that the increase in time looking at weapons comes at a cost of less time spent looking at faces. Additionally, observers who held firearms while viewing the various scenes showed a general bias to look at faces over objects, but only if the firearm was in a readily usable position (i.e., pointed at the scenes rather than holstered at one’s side). These two effects, weapon focus and the newly found bias to look more at faces when armed, canceled out one another without interacting. This evidence confirms that the action capabilities of the observer alter more than just perceptual mechanisms and that holding a weapon can change attentional priorities. Theoretical and real-world implications are discussed.