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51.
Fos protein expression in olfactory-related brain areas after learning and after reactivation of a slowly acquired olfactory discrimination task in the rat 下载免费PDF全文
Roullet F Liénard F Datiche F Cattarelli M 《Learning & memory (Cold Spring Harbor, N.Y.)》2005,12(3):307-317
Fos protein immunodetection was used to investigate the neuronal activation elicited in some olfactory-related areas after either learning of an olfactory discrimination task or its reactivation 10 d later. Trained rats (T) progressively acquired the association between one odor of a pair and water-reward in a four-arm maze. Two groups of pseudotrained rats were used: PO rats were not water restricted and were submitted to the olfactory stimuli in the maze without any reinforcement, whereas PW rats were water-deprived and systematically received water in the maze without any odorous stimulation. When the discrimination task was well mastered, a significantly lower Fos immunoreactivity was observed in T rats compared to PW and PO rats in most of the analyzed brain areas, which could reflect the post-acquisition consolidation process. Following memory reactivation, differences in Fos immunoreactivity between trained and some pseudotrained rats were found in the anterior part of piriform cortex, CA3, and orbitofrontal cortex. We also observed that Fos labeling was significantly higher in trained rats after memory reactivation than after acquisition of the olfactory task in most of the brain areas examined. Our results support the assumption of a differential involvement of neuronal networks after either learning or reactivation of an olfactory discrimination task. 相似文献
52.
Dovidio JF ten Vergert M Stewart TL Gaertner SL Johnson JD Esses VM Riek BM Pearson AR 《Personality & social psychology bulletin》2004,30(12):1537-1549
The present work investigated mechanisms by which Whites' prejudice toward Blacks can be reduced (Study 1) and explored how creating a common ingroup identity can reduce prejudice by promoting these processes (Study 2). In Study 1, White participants who viewed a videotape depicting examples of racial discrimination and who imagined the victim's feelings showed greater decreases in prejudice toward Blacks than did those in the objective and no instruction conditions. Among the potential mediating affective and cognitive variables examined, reductions in prejudice were mediated primarily by feelings associated with perceived injustice. In Study 2, an intervention designed to increase perceptions of a common group identity before viewing the videotape, reading that a terrorist threat was directed at all Americans versus directed just at White Americans, also reduced prejudice toward Blacks through increases in feelings of injustice. 相似文献
53.
Abstract-Examining the receptive fields of brain signals can elucidate how information impinging on the former modulates the latter. We applied this time-honored approach in early vision to the higher-level brain processes underlying face categorizations. Electroencephalograms in response to face-information samples were recorded while observers resolved two different categorizations (gender, expressive or not). Using a method with low bias and low variance, we compared, in a common space of information states, the information determining behavior (accuracy and reaction time) with the information that modulates emergent brain signals associated with early face encoding and later category decision. Our results provide a time line for face processing in which selective attention to diagnostic information for categorizing stimuli (the eyes and their second-order relationships in gender categorization; the mouth in expressive-or-not categorization) correlates with late electrophysiological (P300) activity, whereas early face-sensitive occipito-temporal (N170) activity is mainly driven by the contralateral eye, irrespective of the categorization task. 相似文献
54.
Adam?M.?Malin Blaine?J.?FowersEmail author 《Current psychology (New Brunswick, N.J.)》2004,23(1):77-85
This study examined the emotional response of 110 adolescents living in the New York metropolitan area one month and five
months after the destruction of the World Trade Center (WTC) by terrorists. The purpose of the study was to assess emerging
hypotheses in political psychology that suggest that there are differential emotional responses to a national trauma that
recede in predictable directions. The results followed predictions and indicate that adolescents experienced a higher level
of emotions related to the Crisis and Bereavement dimension than affect associated with Vulnerability and that the emotional
response decreased during the four-month follow-up period. There was no effect on emotional response from the biological sex
or political orientation of the respondents, which is inconsistent with other studies in the literature. The absence of a
political orientation effect is explained in terms of the lack of a domestic ideological difference in response to the terrorist
attack. 相似文献
55.
As people study more facts about a concept, it takes longer to retrieve a particular fact about that concept. This fan effect
(Anderson, 1974) has been attributed to competition among associations to a concept. Alternatively, the mental-model theory
(Radvansky & Zacks, 1991) suggests that the fan effect disappears when the related concepts are organized into a single mental
model. In the present study, attentional focus was manipulated to affect the mental model to be constructed. One group of
participants focused on the person dimension of personlocation pairs, whereas the other group focused on the location dimension.
The result showed that the fan effect with the focused dimension was greater than the fan effect with the nonfocused dimension,
which is contrary to the mental-model theory. The number of associations with a concept is indeed crucial during retrieval,
and the importance of the information seems to be accentuated with attentional focus. 相似文献
56.
The concept of informed consent was one of the most fruitful ideas that deeply changed the relationships between physicians
and their patients from paternalism to respect for the personal autonomy of subjects needing professional medical care. The
great progress in medicine, also involving the pharmaceutical industry, has created an increasing need to perform different
clinical and experimental trials. The evolution of clinical research in the last decades has influenced strongly the design
of these studies. One of the most important changes in this field has been the use of placebo groups in double-blind controlled
studies. The controversies have involved not only the use of placebo when standard or proven treatment was available, but
also some specific problems concerning the procedure of obtaining informed consent in such trials. This paper briefly presents
the evolution of informed consent in Poland as well as different ethical and legal problems concerning informed consent and
the use of placebo controls in clinical trials.
An earlier version of this paper was presented at an international conference, “Placebo: Its Action and Place in Health Research
Today,” held in Warsaw, Poland on 12–13 April, 2003. 相似文献
57.
Neurophysiological experiments with monkeys have demonstrated that working memory (WM) is associated with persistent neural
activity in multiple brain regions, such as the prefrontal cortex (PFC), the parietal cortex, and posterior unimodal association
areas. WM maintenance is believed to require the coordination of these brain regions, which do not function in isolation but,
rather, interact to maintain visual percepts that are no longer present in the environment. However, single-unit physiology
studies and traditional univariate analyses of functional brain imaging data cannot evaluate interactions between distant
brain regions, and so evidence of regional integration during WM maintenance is largely indirect. In this study, we utilized
a recently developed multivariate analysis method that allows us to explore functional connectivity between brain regions
during the distinct stages of a delayed face recognition task. To characterize the neural network mediating the on-line maintenance
of faces, the fusiform face area (FFA) was defined as a seed and was then used to generate whole-brain correlation maps. A
random effects analysis of the correlation data revealed a network of brain regions exhibiting significant correlations with
the FFA seed during the WM delay period. This maintenance network included the dorsolateral and ventrolateral PFC, the premotor
cortex, the intraparietal sulcus, the caudate nucleus, the thalamus, the hippocampus, and occipitotemporal regions. These
findings support the notion that the coordinated functional interaction between nodes of a widely distributed network underlies
the active maintenance of a perceptual representation. 相似文献
58.
The use of a distractor-assigned response slows later responding in a location negative priming task
Responding to a target's location takes longer when that location has recently contained a distractor event (ignored-repetition [IR] trial) relative to when it has been unoccupied (control trial). This is known as the location negative priming (NP) effect. We aimed to determine whether the elevated reaction time observed for IR trials was due to the reuse of a distractor location (location locus) and/or to the need to execute a (just inhibited) distractor response (response locus). We isolated these loci latency effects by using many-to-one and one-to-many location-response assignments. Our results showed that reusing a distractor location hastened target processing at that position (facilitative location locus), whereas the production of a distractor response was associated with a time cost (interfering response locus). Accordingly, part of the latency elevation seen with IR trials results from the need on these occasions to execute ajust inhibited (distractor) response, and, hence, the location NP effect has a response locus. 相似文献
59.
The present experiment examined the one-target advantage (OTA) with regard to saccadic eye movements. The OTA, previously found with manual pointing responses, refers to the finding that movements are executed faster when the limb is allowed to stop on the target compared to the situation where it has to proceed and hit a second target. Using an adapted limb movement OTA task, saccades of 5 degrees and 15 degrees were made to (a) a single target (one-target), (b) one target and immediately to another target without a change in direction (two-target-extension), and (c) one target and immediately back to the start location (two-target-reversal). Unlike manual movements, the movement times for the initial saccade in the two-target-extension condition were not prolonged compared to either of the other two conditions. Moreover, this pattern of results was found for both the shorter and longer amplitude saccades. The results indicate that the OTA does not occur in the oculomotor system and therefore is not a general motor control phenomenon. 相似文献
60.
Pierce JD Cohen AB Ulrich PM 《Journal of comparative psychology (Washington, D.C. : 1983)》2004,118(1):14-19
Substantial variation exists in the importance of olfaction in influencing individuals' preferences, yet the sources of this variation remain elusive. The authors explored responsivity to 2 odorants as 1 potential source. Participants (N = 258) completed the Affective Impact of Odor Scale and were assessed for responsivity to the putative human pheromone androstenone and amyl acetate. Results showed a significant relationship between odorant responsivity and self-reports of the influence of odors. People able to smell androstenone more commonly reported odors as having a negative effect on interpersonal relationships than did people anosmic to androstenone, whereas responsivity to amyl acetate was associated with positive effects of odors on relationships. Responsivity to certain odorants may be an important factor affecting human social interactions. 相似文献