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151.
Developing human-nonhuman chimeras in human stem cell research: ethical issues and boundaries 总被引:1,自引:0,他引:1
The transplantation of adult human neural stem cells into prenatal non-humans offers an avenue for studying human neural cell development without direct use of human embryos. However, such experiments raise significant ethical concerns about mixing human and nonhuman materials in ways that could result in the development of human-nonhuman chimeras. This paper examines four arguments against such research, the moral taboo, species integrity, "unnaturalness," and human dignity arguments, and finds the last plausible. It argues that the transfer of human brain or retinal stem cells to nonhuman embryos would not result in the development of human-nonhuman chimeras that denigrate human dignity, provided such stem cells are dissociated. The article provides guidelines that set ethical boundaries for conducting such research that are consonant with the requirements of human dignity. 相似文献
152.
Hierarchical agglomerative cluster analysis (HACA) may yield different solutions under permutations of the input order of the data. This instability is caused by ties, either in the initial proximity matrix or arising during agglomeration. The authors recommend to repeat the analysis on a large number of random permutations of the rows and columns of the proximity matrix and select a solution with the highest goodness-of-fit. This approach was implemented in an SPSS add-in, PermuCLUSTER, which can perform all HACA methods of SPSS. Analyses of 2 data sets show that (a) results are affected by input order, (b) instability in one method co-occurs with instability in other methods, and (c) some instability effects are more dramatic because they occur at higher agglomeration levels. 相似文献
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154.
Visual analogue scale has been shown to reflect subjective feelings but rarely has it been used for musculoskeletal fatigue so in the present study VAS ratings were used to quantify musculoskeletal fatigue. A total of 20 students underwent a fatigue protocol (M age=21.3 yr., SD= 1.0). A series of randomized external loads at 0, 5, 10, 15, 25, 35, and 50% of the maximum voluntary contraction was generated by the BTE Primus and applied at the distal end of the dominant arm, which was sustained at the 90 degrees forward flexion position. After 60 sec. of force exertion for each loading, the subject marked the scale to reflect their extent of fatigue at the shoulder muscle. Analysis showed fatigue scores were significantly correlated with the percentages of maximum load applied (r =.73, p < or = .01). The correlation between higher external loads (25-50% maximum load) and fatigue scores was .57 (p < or = .01) and that for lower external loads (0-15% maximum load) was .44 (p < or = .01). The validity of using a visual analogue scale as a measure of musculoskeletal fatigue requires further study, particularly for a low load. 相似文献
155.
Bottom-up and top-down control in visual search 总被引:2,自引:0,他引:2
Previous research suggests that the allocation of attention is largely controlled either in a stimulus-driven or in a goal-driven manner. To date, few studies have systematically manipulated variables affecting stimulus-driven and goal-driven selection independently in order to investigate how both manners of control interrelate and affect performance in visual search. In the present study observers were presented with search displays consisting of an array of line segments rotated at various orientations. The task of observers was to indicate the presence or absence of a vertical line segment (the target) presented amongst a series of nontargets and possibly one distractor. By varying the absolute differences in orientation between the target, nontargets, and distractors, relative target-distractor salience and target-distractor similarity were independently manipulated to investigate the contribution of stimulus-driven and goal-driven control. The major result was that relative target-distractor salience and target-distractor similarity affected search performance independently. Performance was better in cases where the irrelevant distractor was not a salient item in the search display and did not look similar to the target. The results are discussed in terms of models of attentional control. 相似文献
156.
This study explored the effects of ageing on working memory by means of the directed forgetting procedure designed by Reed (1970). Memory for a letter trigram was compared in conditions where it was either presented alone (single-item), or followed by a second trigram to be recalled (interference), or followed by a second trigram to be forgotten (directed forgetting). The results clearly indicated that elderly participants inhibited the no-longer-relevant information less efficiently (recall in the single-item condition - recall in the directed forgetting condition), as predicted by the model of Hasher and Zacks (1988). However, the results also demonstrated that sensitivity to interference (recall in the single-item condition - recall in the interference condition) increased in the condition in which no inhibition was directly required. 相似文献
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159.
Tim van Gelder Melanie Bissett Geoff Cumming 《Revue canadienne de psychologie expérimentale》2004,58(2):142-152
People generally develop some degree of competence in general informal reasoning and argument skills, but how do they go beyond this to attain higher expertise? Ericsson has proposed that high-level expertise in a variety of domains is cultivated through a specific type of practice, referred to as "deliberate practice." Applying this framework yields the empirical hypothesis that high-level expertise in informal reasoning is the outcome of extensive, deliberate practice. This paper reports results from two studies evaluating the hypothesis. University student participants completed 12 weeks of deliberate practice in informal reasoning. Quantity of practice was recorded by computer, and additionally assessed via self-report. The hypothesis was supported: Students in both studies showed a large improvement, and practice, as measured by computer, was related to amount of improvement in informal reasoning. These findings support adopting a deliberate practice approach when attempting to teach or learn expertise in informal reasoning. 相似文献
160.
Switching between spatial stimulus-response mappings: a developmental study of cognitive flexibility
Four different age groups (8-9-year-olds, 11-12-year-olds, 13-15-year-olds and young adults) performed a spatial rule-switch task in which the sorting rule had to be detected on the basis of feedback or on the basis of switch cues. Performance errors were examined on the basis of a recently introduced method of error scoring for the Wisconsin Card Sorting Task (WCST; Barcelo & Knight, 2002). This method allowed us to differentiate between errors due to failure-to-maintain-set (distraction errors) and errors due to failure-to-switch-set (perseverative errors). The anticipated age differences in performance errors were most pronounced for perseverative errors between 8-9 years and 11-12 years, but for distraction errors adult levels were not reached until 13-15 years. These findings were interpreted to support the notion that set switching and set maintenance follow distinct developmental trajectories. 相似文献