Lifestyle Risk Factors for Breast Cancer in BRCA1/2-Mutation Carriers Around Childbearing Age

BRCA1/2-mutation carriers are at high risk of breast cancer (BC) and ovarian cancer. Physical inactivity, overweight (body mass index ≥25, BMI), smoking, and alcohol consumption are jointly responsible for about 1 in 4 postmenopausal BC cases in the general population. Limited evidence suggests physical activity also increases BC risk in BRCA1/2-mutation carriers. Women who have children often reduce physical activity and have weight gain, which increases BC risk. We assessed aforementioned lifestyle factors in a cohort of 268 BRCA1/2-mutation carriers around childbearing age (born between 1968 and 1983, median age 33 years, range 21–44). Furthermore, we evaluated the effect of having children on physical inactivity and overweight. Carriers were asked about lifestyle 4–6 weeks after genetic diagnosis at the Familial Cancer Clinic Nijmegen. Physical inactivity was defined as sports activity fewer than once a week. Carriers were categorized according to the age of their youngest child (no children, age 0–3 years and ≥4 years). In total, 48% of carriers were physically inactive, 41% were overweight, 27% smoked, and 70% consumed alcohol (3% ≥8 beverages/week). Physical inactivity was 4–5 times more likely in carriers with children. Overweight was not associated with having children. Carriers with children are a subgroup that may specifically benefit from lifestyle support to reduce BC risk.     

Familial risk of early suicide: variations by age and sex of children and parents

To determine familial risk of early suicide, data on cause of death of all Dutch residents aged 20-55 years who died between 1995 and 2001 were linked to data of their parents. Men whose father died by suicide had a higher odds of suicide themselves, relative to men whose father died of other causes (Odds Ratio (OR): 2.5; 95% confidence interval: 1.8-3.6). This effect was slightly stronger in the case of mother's suicide (OR: 3.4; 2.3-5.0). The same effect was observed for women, for suicide by father (OR: 2.2; 1.3-3.7) and mother (OR: 4.6; 2.6-8.0). The odds of suicide increased with decreasing age at death of parent. Parental suicide is predictive for offspring suicide. Our data suggest that the predictive value is higher in case the mother died by suicide, particularly if the mother died by suicide at a young age.     

Applying the job demands–resources model to the work–home interface: A study among medical residents and their partners

Work–home interference (WHI) is a prevalent problem because most employees have substantial family responsibilities on top of their work demands. The present study hypothesized that high job demands in combination with low job resources contribute to WHI. The job demands–resources (JD-R) model was used as a theoretical framework. Using a sample of 230 medical residents and their partners, our results show that the combination of high job demands (i.e., work overload, emotional and cognitive demands) and low job resources (i.e., participation in decision making, supervisory coaching, feedback, and opportunities for development) was positively related to partner ratings of the employee's WHI. When job resources were high, most job demands were not related to WHI. These findings show that the JD-R model is a conceptual framework that can be fruitfully applied to the work–family interface, adding to our understanding of which particular job designs facilitate or prevent work–home interference.     

Newborns' face recognition is based on spatial frequencies below 0.5 cycles per degree

A critical question in Cognitive Science concerns how knowledge of specific domains emerges during development. Here we examined how limitations of the visual system during the first days of life may shape subsequent development of face processing abilities. By manipulating the bands of spatial frequencies of face images, we investigated what is the nature of the visual information that newborn infants rely on to perform face recognition. Newborns were able to extract from a face the visual information lying from 0 to 1 cpd (Experiment 1), but only a narrower 0-0.5 cpd spatial frequency range was successful to accomplish face recognition (Experiment 2). These results provide the first empirical support of a low spatial frequency advantage in individual face recognition at birth and suggest that early in life low-level, non-specific perceptual constraints affect the development of the face processing system.     

Anxiety and post-traumatic stress symptoms following wisdom tooth removal

The purpose of the present study was to determine the psychological impact of wisdom teeth removal and to identify the psychological risk factors for the development of dental anxiety and post-traumatic stress symptoms. Participants were 34 consecutive elective patients referred for surgical removal of a wisdom tooth under local anesthesia. Frequency of previous distressing dental events and general traumatic life events were assessed at baseline (t1), and emotional distress (pain, state anxiety and disturbance) immediately after treatment (t2). Post-traumatic stress responses were determined three days after treatment (t3), and at four weeks follow-up (t4), while severity of dental trait anxiety was assessed at t1 and at t4. Two patients (8%) met screening criteria for Post-Traumatic Stress Disorder (PTSD) at t4. Multivariate analysis revealed that previous exposure to distressing dental events and pre-operative anxiety level predicted anxiety level at t4, accounting for 71% of the variance. Severity of pain during treatment was a significant predictor variable of PTSD symptom severity at t4 (25% explained variance). The findings underline the importance of pain-free treatments and awareness of patients' individual predisposition to anxiety or trauma-related symptoms to reduce the risk of iatrogenic psychological harm.     

Happiness in the Garden of Epicurus

Epicurus was a philosopher who lived in Greece in the 3rd century B.C. Like his contemporaries, he was much concerned with the question of how to live a good life. In his view the Chief Good is to decrease pain and increase pleasure. Though Epicurus is reputed for advocating the pursuit of refined sensorial pleasures, he recognized the need for deferring gratification or enduring pain. He advised his followers to lead a modest and contemplative life in friendly communities. His advice can be characterized as ‘serene hedonism’. This paper explains that position and considers its applicability for the present day. It concludes that Epicureanism was quite accurate in describing the conditions of happiness and that he offered valuable guidelines in dealing with hardship and difficult emotional content. His ideas that happiness is the same as the absence of pain and that one should withdraw from society are less fortunate. It made him assume that happiness automatically follows if one is in the right state of mind, and that there is no need to actively seek interaction with the environment for the betterment of the circumstances of life. However, Epicurus’ advice might have been a good option for his contemporaries given the societal turmoil in his times.