Discrimination of computer-synthesized speech

The effects of learning on the discrimination of computer-synthesized speech was assessed by presenting 100 computer-produced monosyllabic words to 2 groups of 15 adult subjects. One group's errors were corrected while the other group's errors were uncorrected. A comparison of errors on the first 50 vs the second 50 presentations showed significant improvement for corrected group only. It was concluded that the discrimination of computer-synthesized monosyllables can be improved with correction of errors but is still about 14% poorer than the discrimination of human speech.     

Experiences with the indirect Clausen Test using NTA as an antigen in multiple sclerosis and other neurologic diseases

The present study based on the indirect Clausen-test using NTA and PHA as antigens contributed to therapy control and possibly prognosis assessment rather than to immunological differential diagnosis.     

Catamnestic surveys on somato-psychosocial development in childhood and adolescence of patients with unipolar depressive and bipolar manic-depressive psychoses

The somatic and psychosocial development of 80 subjects with manifest affective-phasic psychoses is studied retrospectively and compared with that of an identically sized control group consisting of neuropsychiatrically healthy subjects. Statistically significant differences were found particularly in the answers to questions dealing with social situation and social adaptability. Achievement at school and vocational qualifications were lower among the parents of the patients than among those of the healthy subjects. Characteristic features of the patients' childhood and adolescence were transient depression, often for no apparent cause, and maladaption, and vocational wishes were fulfilled less often than among the controls. The patients experienced greater difficulty in settling in to a new group due to their contact difficulties.     

Acoustically evoked brain stem potential in Wilson disease

By 48 patients with Wilson's disease the brainstem acoustic evoked potentials were stated. There were 35 pathological findings (73%), 13 were normal (27%). The waves, determined by the middle and upper brainstem (Pons and Mesencephalon) showed most of all pathological changes. Those patients with forms of Wilson's disease called Pseudoskelerose and Pseudoparkinson showed the most pathological findings. But one could watch these findings by about 30% of patients in preclinical stage. This method can possibly be used for early detection of disorders of brainstem functions and in the same way it can be used for control of treatment by patients in preclinical stage.     

Value of mechanographic studies in neuromuscular function diagnosis

Mechanographic examinations have hitherto played only a minor role in general clinical neuromuscular functional diagnostics. The purpose of this contribution is, therefore, to present an appropriate recording apparatus (W. Zett , 1969), to report on the values that can be considered normal and to outline the diagnostic value of the method using clinical applications as examples. Special value is attached to simultaneous recording of the EMG and the mechanograph because this method permits differentiated conclusions to be drawn regarding disturbances in muscular activity, the electromechanical coupling and the actual process of contraction. The method is also important for pharmacological investigations and should be used principally in connection with musclepathology for objectifying the effects of medication.