Imaging or imagining? A neuroethics challenge informed by genetics

From a twenty-first century partnership between bioethics and neuroscience, the modern field of neuroethics is emerging, and technologies enabling functional neuroimaging with unprecedented sensitivity have brought new ethical, social and legal issues to the forefront. Some issues, akin to those surrounding modern genetics, raise critical questions regarding prediction of disease, privacy and identity. However, with new and still-evolving insights into our neurobiology and previously unquantifiable features of profoundly personal behaviors such as social attitude, value and moral agency, the difficulty of carefully and properly interpreting the relationship between brain findings and our own self-concept is unprecedented. Therefore, while the ethics of genetics provides a legitimate starting point--even a backbone--for tackling ethical issues in neuroimaging, they do not suffice. Drawing on recent neuroimaging findings and their plausible real-world applications, we argue that interpretation of neuroimaging data is a key epistemological and ethical challenge. This challenge is two-fold. First, at the scientific level, the sheer complexity of neuroscience research poses challenges for integration of knowledge and meaningful interpretation of data. Second, at the social and cultural level, we find that interpretations of imaging studies are bound by cultural and anthropological frameworks. In particular, the introduction of concepts of self and personhood in neuroimaging illustrates the interaction of interpretation levels and is a major reason why ethical reflection on genetics will only partially help settle neuroethical issues. Indeed, ethical interpretation of such findings will necessitate not only traditional bioethical input but also a wider perspective on the construction of scientific knowledge.     

Rhythm perception and differences in accent weights for musicians and nonmusicians

In order to investigate the contribution of harmonic—temporal and structural features to the perception of musical rhythm, three experiments were conducted in which a harmonic and a temporal accent were pitted against each other in such a way as to form five possible patterns. In three experiments, the temporal structure of various chord progressions was manipulated in an effort to determine the harmonic contributions to the inference of meter. The final experiment differed from the first two in the use of nondiatonic progressions that implied an unlikely key modulation. In all experiments, musicians and nonmusicians were requested to report perceived rhythm patterns in an attempt to determine the relative salience of various accents. Results indicated that changes in the temporal structure led to predictable change in an inferred meter, and that all diatonic chord progressions led to similar patterns of responses in which coincidences of harmonic, temporal, and metrical accents were perceptually salient events. Unusual progressions implying key modulations resulted in a qualitatively distinct pattern of results, and, in all experiments, amount of formal musical training was found to be a good predictor of the use of harmonic cues.     

Perceived pitch class of isolated musical triads

A paired-comparisons task was used to determine which note of a pure-tone triad sounded most similar to the triad. Musically inexperienced Ss showed no systematic preference, experienced Ss consistently preferred the highest note in the triad, and professional musicians split equally between preferring the highest note and the root note. Preference for the root note shifted to preference for the highest note as the triad type became increasingly inharmonic, suggesting that the former depended on inference of a missing fundamental. When Ss were asked to vocally reproduce the pitch they heard when listening to a triad, similar results were obtained, except that a root-note preference was not detectable in Ss with less musical experience. Preference for the root note was also facilitated by use of octave-replicated tones, and this increase was shown to be due to obscuring of pitch-height cues, rather than harmonic complexity.     

Harmonic accents in inference of metrical structure and perception of rhythm patterns

Research on rhythmic structure is somewhat fragmented, due in part to differential use ofterminology and a lack of research on the timing of harmonic accents. In this study, a harmonic and a temporal accent were pitted against each other in such a way as to form different rhythm patterns. In addition, two harmonic conditions that varied in the frequency of chord presentations (i.e., the composite rhythm) but not in the frequency of chord changes (i.e., the harmonic rhythm) were presented. Musicians and nonmusicians were requested to report perceived rhythm patterns inan attempt to determine the relative salience of the harmonic and temporal accents. In addition, a behavioral measure of the perceivedmeter was taken. Results indicated that the location of chord changes was the main determinant of subjects’ rhythmic perceptions and the perceived onset of a measure. Furthermore, although subjects primarily inferred different meters based on the composite rhythm, an interaction of metrical and rhythmic choices was found, indicating that perception ofrhythm patterns and inference of metrical structure may notalways be independent.     

Turbo Pascal timing routines for the IBM microcomputer family

Two Turbo Pascal (versions 3.0 and 4.0) software timers for the IBM microcomputer family are described: one with a 55-msec resolution and another with a 1-msec resolution. Both can be implemented without additional hardware requirements. The 55-msec timer makes use of the system-time-of-day clock; the 1-msec timer is a Turbo Pascal translation of the timer described by Bührer, Sparrer, and Weitkunat (1987). The logic of each timer is shown by a short demonstration program.     

Development and Validation of a Deontic Justice Scale

This paper describes the development and validation of a deontic justice scale (DJS). Study 1 (n = 124) was conducted to test the initial 36‐item version of the scale. It resulted in the reduction of the initial scale to 18 items, including 3 dimensions: moral obligation (8 items), moral accountability (6 items), and moral outrage (4 items). Study 2 (n = 101) was conducted to examine the construct validity and confirm the factor structure of the DJS. Findings from both studies showed evidence of the scale's construct validity. They also showed that deontic justice is a multidimensional construct encompassing moral obligation, moral accountability, and moral outrage. The scale's implications for use as an adequate research instrument are discussed.     

Neurofunctional (re)organization underlying narrative discourse processing in aging: evidence from fNIRS

Relatively few studies have analyzed the mechanisms underlying the cognitive changes that affect language in the elderly, and fewer have done so for narrative discourse. The goal of this study was to explore the neurofunctional changes associated with aging for different components of narrative discourse. Functional near-infrared spectroscopy (fNIRS) and behavioral data on 10 younger adults and 10 healthy elderly participants were collected. Ten younger adults in a non-proficient second language condition were included to explore the possibility that the age-related neurofunctional reorganization partly expresses demanding resource allocation. Results show within- and across-hemispheric differences in the neurofunctional pattern of activation in the older participants with reference to the younger ones, partially shared with the low-proficiency young adults, providing support for the recognized mechanisms underlying neural reserve and compensation. fNIRS was shown to be appropriate for studying the age-related neurofunctional reorganization of complex cognitive abilities.     

Precautionary principle and normativity: brief remarks on the complex relationship between law and the risks

The precautionary principle is objet of an intense discussion in different legal orders. It is easy to understand the reason why: the regulation of risks challenges the legal thought. The positivist approach has shown its limits. It is now important to ask ourselves about the way in which we can deal with uncertainty effectively. The task is difficult, but we can point out two different aspects. Firstly, it is important to understand the complexity of the technological risks in a transdisciplinary way. This is an unavoidable step in evaluating the ability of the law to prevent them. Secondly, the precautionary principle presupposes a pluralistic conception of nature in which the economic sphere can be seen as a tool to express the relationship between man and nature.     

Screen Time as a Mechanism Through Which Cumulative Risk is Related to Child Socioemotional and Developmental Outcomes in Early Childhood

Research on Child and Adolescent Psychopathology - Socio-demographic risks are associated with higher child screen time and higher screen time is associated with poor socioemotional and...     

Boghossian’s Inference Argument against Content Externalism Reversed*

I deal here with one of Boghossian’s arguments against content externalism, related to our inferential rationality (to use his term). According to his reasoning, the apriority of our logical abilities is inconsistent with certain externalist assumptions. Nevertheless, the problem constitutes an important challenge for any theory of content, not just for externalism. Furthermore, when we examine what internalists may propose to solve the problem, we see that externalists have at their disposal a more promising repertoire of possible replies than internalists. In that sense, insofar as Boghossian’s scenario is relevant to the debate externalism/internalism, it can be seen (against Boghossian’s original intention) as providing additional evidence for content externalism.