A Reinforcer Pathology perspective on relapse

The Reinforcer Pathology theory proposes conditions under which drugs emerge as excessively preferred reinforcers compared to other available reinforcers among drug users. The theory highlights 2 key variables as important determinants of drug preference: (a) excessive preference for immediate rewards (high discounting of future rewards); and (b) excessive valuation for addictive reinforcers (e.g., drugs). Two iterations of the Reinforcer Pathology theory exist with the latest iteration (i.e., Reinforcer Pathology 2.0) specifying that the temporal window of reinforcer integration (measured by delay discounting) is a determinant of reinforcer value. The 2 iterations of the Reinforcer Pathology theory are described. A novel insight and understanding of abstinence and relapse from a Reinforcer Pathology perspective, limitations, and future directions are discussed. The Reinforcer Pathology theory continues the long-standing efforts to scientifically understand and better define novel concepts and methods to further translational research and improve treatment outcomes. Exploring the complementary relation between the Reinforcer Pathology perspective and other current approaches could have a valuable effect.     

Do we access meaning when we name Arabic digits? Electrophysiological evidence

In this study, we evaluated whether the naming of Arabic digits required access to semantic information. Participants named pictures and Arabic digits blocked by category or intermixed with exemplars of other categories while behavioural and electrophysiological measures were gathered. Pictures were named slower and Arabic digits faster in the blocked context relative to the mixed context. Around 350–450 ms after the presentation of pictures and Arabic digits, brain waves were more positive in anterior regions and more negative in posterior regions when the blocked context was compared with the mixed context. The pattern of electrophysiological results suggests that pictures and Arabic digits are both processed semantically and they are subject to repetition effects during the naming task.     

Auditory temporal discrimination by trained listeners

Previous reports from this laboratory have shown that untrained listeners cannot name the order of sounds in extended sequences of unrelated items such as hisses, tones, and buzzes at item durations of 200 msec, even though identification of order for the sounds of speech and music is accomplished readily at much shorter item durations. The present study indicates that under appropriate conditions subjects can be trained to distinguish between and to identify permuted orders within sequences of nonrelated sounds each lasting only 10 msec or less. Evidence is presented suggesting that much of what passes for direct identification of order is actually based on prior identification of a larger pattern. Two principal mechanisms seem to mediate discrimination of auditory temporal order: (1) fine resolution (requiring prior training) permitting identification of over-all patterns and capable of operating with item durations of only a few msec; (2) coarse resolution (special prior training not required) allowing naming of order of items having minimal durations usually above 200 msec for unfamiliar sequences.