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1.
Transient hippocampal down-regulation of Kv1.1 subunit mRNA during associative learning in rats 下载免费PDF全文
Kourrich S Manrique C Salin P Mourre C 《Learning & memory (Cold Spring Harbor, N.Y.)》2005,12(5):511-519
Voltage-gated potassium channels (Kv) are critically involved in learning and memory processes. It is not known, however, whether the expression of the Kv1.1 subunit, constituting Kv1 channels, can be specifically regulated in brain areas important for learning and memory processing. Radioactive in situ hybridization was used to evaluate the content of Kv1.1 α-subunit mRNA in the olfactory bulb, ventral, and dorsal hippocampus at different stages of an odor-discrimination associative task in rats. Naive, conditioned, and pseudoconditioned animals were sacrificed at different times either prior to a two-odor significance learning or after odor discrimination was established. Important decreases of Kv1.1 mRNA levels were transiently observed in the ventral hippocampus before successful learning when compared with the pseudoconditioned group. Moreover, temporal group analysis showed significant labeling alterations in the hippocampus of conditioned and pseudoconditioned groups throughout the training. Finally, Kv1.1 mRNA levels in the hippocampus were positively correlated with odor-reward association learning in rats that were beginning to discriminate between odors. These findings indicate that the Kv1.1 subunit is transiently down-regulated in the early stages of learning and suggest that Kv1 channel expression regulation is critical for the modification of neuronal substrates underlying new information acquisition. 相似文献
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When a chromatic (eg light-blue) annulus surrounds the central gap of an Ehrenstein figure so as to connect the inner ends of the radial lines, a striking new lightness effect emerges: the central white disk has both a self-luminous quality (brighter than in the regular Ehrenstein figure) and a surface quality (dense, paste-like). Self-luminous and surface qualities do not ordinarily appear co-extensively: hence, the brightness induction is called anomalous. In experiment 1, subjects separately scaled self-luminous and surface properties, and in experiment 2, brightness was nulled by physically darkening the central gap. Experiments 3 and 4 were designed to evaluate the importance of chromatic versus achromatic properties of the annulus; other aspects of the annulus (width or the inclusion of a thin black ring inside or outside the chromatic annulus) were tested in experiments 5-7. In experiments 8-12, subjects rated the brightness of modified Ehrenstein figures varying the radial lines (number, length, width, contrast, arrangement). Variation of these parameters generally affected brightness enhancement in the Ehrenstein figure and anomalous brightness induction in a similar manner, but was stronger for the latter effect. On the basis of these results, anomalous brightness induction is attributed to a surface induction process triggered by an interaction between illusory brightness enhancement (due to the radial lines) and border ownership (due to the blue annulus). 相似文献
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Lothar Pickehain 《Integrative psychological & behavioral science》1999,34(2):85-89
By his experimental and theoretical work on the physiology and pathophysiology of the higher nervous activity I.P. Pavlov
significantly influenced the development of Neuroscience. During the 1950 Pavlovian Conference in Moscow, Stalin and the Communist
Party tried to dogmatize his and his pupils’ fundamental theories. But the Pavlovian ideas were developed by his pupils in
open discussions with representatives of other schools in a very creative way, opening the doors for a systemic approach to
understanding the integrative functional systems of brain and behavior. Pavlov emphasized the high plasticity of the central
nervous system investigated the complex functional systems within the brain and between the organism and its environment,
and designed models for pathological deviations of the higher nervous activity. During his last years, he freed himself from
the strong deterministic view and characterized the organism and its environment as a self-organizing system.
Lecture at the Annual Meeting of the Pavlovian Society, November 1, 1998, Dusseldorf, Germany. 相似文献
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Beutel ME Knickenberg RJ Krug B Mund S Schattenburg L Zwerenz R 《International journal of group psychotherapy》2006,56(3):285-305
Conflicts arising from the work setting have remained a neglected issue in psychotherapy. To address this, the present study investigated the effectiveness of a manualized focal group treatment for psychotherapeutic inpatients suffering from vocational strains and conflicts and identified predictors of outcome. Cohorts of patients were assigned either to a treatment (N=144) or control condition (N=135). The group therapy intervention was found to be highly accepted by participants who were also more optimistic about returning to work and more favorable in their evaluations of treatment than patients in the treatment-as-usual condition. Group climate was found to be a predictor of favorable outcome. The findings suggest that a group therapy intervention with a strong emphasis on motivations and attitudes about work may be particularly suitable to deal with vocational conflicts and strains. 相似文献
6.
Abstract The concepts of children, adolescents and their mothers with regard to different aspects of health and illness in general and five specific diseases were explored in this study. An exploration with fully standardised questions and open answers was subjected to a content analysis. A reliable rating system was developed to score the sophistication of the answers. The study included 99 Ss of the age groups 5, 8, 12 and 16 years, as well as 48 mothers of the children. Many children and adolescents were able to define health positively (well-being) and not merely as the absence of illness. The definition of illness in general was frequently composed of somatic symptoms and disorders, feeling poorly and things one would like to accomplish but can't. The causality explanations of illness in general were dominated by contagion. The concepts of the older children and the mothers were richer, more elaborated, less concrete and less action-oriented than those of the younger children. However, abstract formulations and complex aspects of illness were very rarely expressed. In addition, concepts regarding the characteristics (definition, symptoms, causality, treatment and prevention) of five diseases (cold, measles, heart infarction, cancer and AIDS) were measured. The pattern of results was strongly influenced by age. By and large, the development of most disease concepts was linear with significant differences between age groups. Conversely, within a given age group, significant differences were found in the cognitive level of disease characteristics, either with respect to the same disease or between different diseases (“horizontal shifts”). 相似文献
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We present select examples of how visual phenomena can serve as tools to uncoverbrain mechanisms. Specifically, receptive field organization is proposed as a Gestalt-like neural mechanism of perceptual organization. Appropriate phenomena, such as brightness and orientation contrast, subjective contours, filling-in, and aperture-viewed motion, allow for a quantitative comparison between receptive fields and their psychophysical counterparts, perceptive fields. Phenomenology might thus be extended from the study of perceptual qualities to their transphenomenal substrates, including memory functions. In conclusion, classic issues of Gestalt psychology can now be related to modern “Gestalt psychophysics” and neuroscience. 相似文献
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Lothar Schäfer 《Synthese》1971,23(1):96-120
Ohne ZusammenfassungMein Dank gilt dem Philosoph. Department und dem Institute for the Arts and Humanistic Studies der Pennsylvania State University, die mir in Zusammenhang mit einem dort abgehaltenen Kant-Seminar Gelegenheit zur Ausarbeitung dieses Beitrages gaben. 相似文献