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Wistar rats of three age groups were tested in an automated tunnel-maze system of variable geometry to investigate whether changes in spontaneous locomotor activity and in learning and memory develop differentially or in a correlated fashion as a function of age. Senescent (30 months) as well as mature-adult (17 months) rats showed an age-correlated decline of locomotor activity as compared to the mature-young (5 months) group. Both working-memory (measured as within-trial arm discrimination performance) and reference-memory (measured as avoidance of "blind alley" visits) were severely affected in the senescent group, whereas the middle-aged animals suffered only from a working-memory deficit. The findings provide evidence that locomotor deficits do not necessarily interfere in the assessment of age-related changes in cognitive performance. Furthermore the results support the hypothesis that working and reference memory have different underlying physiological correlates and that these neuronal systems are differentially affected by the aging process. 相似文献
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S W?sser W Handrick F B Spencker W Braun 《Psychiatrie, Neurologie, und medizinische Psychologie》1988,40(2):95-101
Observations on three children with neurolisteriosis (one case of meningitis, two cases of meningoencephalitis, each Serovar 4 b), show that even after the neonatal period, listeriosis must not be ignored in the process of diagnosis and therapy. It is the bacteriological examination of the cerebrospinal fluid, together with the blood culture, and not clinical symptoms and serology that guarantee a timely diagnosis and therapy (ampicillin and gentamicin). 相似文献
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Harald Merckelbach Marcel A. van den Hout Anita Jansen G. Margo van der Molen 《Journal of psychopathology and behavioral assessment》1988,10(4):355-366
The nonrandom distribution of situational fears has been explained by evolutionary survival relevance of specific fears. Thirty-eight stimuli were taken from the literature on preparedness and were scored on fearfulness, objective dangerousness, and spatiotemporal unpredictability by three separate groups of students. The same items were scored on survival relevance by 15 biologists. Fearfulness of cues significantly correlated not only with survival relevance but also, and even more strongly, with dangerousness and unpredictability. While the fear/survival relevance association virtually disappeared when the unpredictability contribution was partialed out, the fear/unpredictability correlation was only marginally affected when controlling for survival relevance. This suggests that nonrandomness of feared stimuli may result from the spatiotemporal unpredictability that is attributed to these stimuli. The current practice of using snakes and spiders as phobia-relevant, and flowers and mushrooms as neutral, cues was not justified by the ratings of the 15 independent experts.This study was supported in part by a grant from the Dutch Organization for Fundamental Research (ZWO/Psychon, 560-268-001). 相似文献
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The main issue of this paper concerns the mediating role of risk appraisal in the relation between past and future behavior. We expected previous risky behavior to heighten risk appraisal, which, in turn, should stimulate preventive behavior. Results ofthree tests of this mediation hypothesis showed that past behavior was strongly related to future behavior; people who behaved hazardously in the past indicated that they tend to do so in the future. Generally, the expected relation between past behavior and risk appraisal was supported. More risky behavior in the past was associated with a heightened risk appraisal. Results also indicate a relation between risk appraisal and future behavior, but in the opposite direction as predicted. Heightened risk appraisal was related to increased levels of risk in future behavior. When predicting future behavior by both risk appraisal and past behavior the effect of risk appraisal on future behavior disappeared, while past behavior remained a strong predictor of future behavior. In a few cases risk appraisal still predicted future behavior when past behavior was controlled for. Unfortunately, these cases showed the opposite relation; i.e., heightened risk appraisal was related to more risky future behavior. Implications of these findings for research on the role of risk appraisal will be discussed. 相似文献
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The authors examined characteristics of Finnish mothers (N = 924) who use hostile child-rearing practices (i.e., they ignore the child, are punitive and irritable, and perceive the child as a burden), practices that have been shown (R?ikk?nen & Keltikangas-J?rvinen, 1992) to predispose children to Type A behavior. The results of this study indicate that two factors--Type A behavior in the mothers and the mothers' sociodemographic background (low occupational status, low educational level and young age)--increase the probability of the mothers' treating their children in a hostile manner. Also, the mothers of boys in this study reported more hostile child-rearing practices than the mothers of girls did. 相似文献