Cocaine-but not methamphetamine-associated memory requires de novo protein synthesis

Context-induced drug craving and continuous drug use manifest the critical roles of specific memory episodes associated with the drug use experiences. Drug-induced conditioned place preference (CPP) in C57BL/6J mouse model, in this regard, is an appropriate behavioral paradigm to study such drug use-associated memories. Requirement of protein synthesis in various forms of long-term memory formation and storage has been phylogenetically demonstrated. This study was undertaken to study the requirement of protein synthesis in the learning and memory aspect of the conditioned place preference induced by cocaine and methamphetamine, two abused drugs of choice in local area. Since pCREB has been documented as a candidate substrate for mediating the drug-induced neuroadaptation, the pCREB level in hippocampus, nucleus accumbens, and prefrontal cortex was examined for its potential participation in the formation of CPP caused by these psychostimulants. We found that cocaine (2.5 and 5.0 mg/kg/dose)-induced CPP was abolished by the pretreatment of anisomycin (50 mg/kg/dose), a protein synthesis inhibitor, whereas methamphetamine (0.5 or 1.0 mg/kg/dose)-induced CPP was not affected by the anisomycin pretreatment. Likewise, cocaine-induced CPP was mitigated by another protein synthesis inhibitor, cycloheximide (15 mg/kg/injection) pretreatment, whereas methamphetamine-induced CPP remained intact by such pretreatment. Moreover, anisomycin treatment 2h after each drug-place pairing disrupted the cocaine-induced CPP, whereas the same treatment did not affect methamphetamine-induced CPP. An increase of accumbal pCREB level was found to associate with the learning phase of cocaine, but not with the learning phase of methamphetamine. We further found that intraaccumbal CREB antisense oligodeoxynucleotide infusion diminished cocaine-induced CPP, whereas did not affect the methamphetamine-induced CPP. Taken together, these data suggest that protein synthesis and accumbal CREB phosphorylation are essential for the learning and consolidation of the cocaine-induced CPP, whereas methamphetamine-induced CPP may be unrelated to the synthesis of new proteins.     

《心理统计学》教学内容的新探索

本文在对当前国内外主要心理统计学教材进行比较的基础上,指出与上个世纪八十年代的心理统计学教材内容相比较,在内容上的新探索主要体现在（1）由“假设检验”的内容中发展出“统计检验力”和“效果大小”的统计指标和估计方法;（2）引进一般线性模型来统合方差分析和回归分析这两种统计方法;（3）适度增加一些“多元统计分析”的内容等三个方面.本文对前两个方面的新内容作了简要评述,并对教材内容的编排方面提出了新的思路.     

心理资本在工作压力源和压力反应问的作用：调节还是中介？

谊研宛采用工作压力源量表、压力反应量表以及积极心理资本问卷对天津市某企业230名员工进行了调查。分析了心理资本与工作压力源和压力反应的关系及其作用机制。结果发现：（1）工作压力源对压力反应有显著的正向预洲作用;（2）心理资本对压力反应有显著的负向预测作用;（3）心理资本在工作压力源与压力反应之间起部分中介作用而不是调节作用,其中中介效应占总效应的比例为16％;（4）心理资本在各种工作压力源与压力反应问均起到中介作用,中介效应和直接效应的比值介于17．4％-26．1％之间。     

“Speak,Lord, Your Servant Is Listening”: Religious Priming Activates Submissive Thoughts and Behaviors

According to many theoretical perspectives, religion is positively associated with submission and conformity. However, no study to date provided experimental evidence for this hypothesis. We did so in two experiments that relied on priming procedures. In Experiment 1, participants were tested for the strength of their religion-submission associations by using a lexical decision task. In Experiment 2, participants were primed with either religious or neutral concepts and were invited or not by the experimenter to take revenge on an individual who had allegedly criticized them. Both studies provided evidence for the expected religion-submission association, although the effects were limited to participants scoring high in personal submissiveness. Among these individuals, religious priming increased the accessibility of submission-related concepts (Experiment 1) and the acceptance of a morally problematic request for revenge (Experiment 2). Discussion focuses on questions for future research and implications for our understanding of religion's role in morality and interpersonal relations.     

Secrets or No Secrets: Confidentiality in Couple Therapy

This paper discusses secrecy in couple therapy from ethical and clinical perspectives. The author explains what secrets mean in terms of therapy and then moves to what controversies are raised by revealing or withholding secrets. The author reviews and evaluates current approaches to handling secrets in couple therapy regarding the use of informed consent. Additionally, the manner of implementation serves as another variable. In this paper, the author presents several scenarios which are widely used. The article ends with a call for further research on how the change of formats in therapy affects confidentiality.     

The Value of a Genetic Counselor: Improving Identification of Cancer Genetic Counseling Patients with Chart Review

Advances in genetics are changing cancer care and requiring institutions to maximize the unique skills of genetics professionals. The identification of genetic syndromes is vital for prevention and management of families with high cancer risks. Despite this, high risk individuals who qualify are often not referred. Genetic counselors could review oncology charts to improve identification. A genetics assessment tool developed by NCI Community Cancer Centers Program was used to perform self-assessment of the genetics program. A weekly report of all new oncology patients was provided to a genetic counselor for chart review. In 2010, 58 % of all eligible patients (n?=?152) were offered a genetics evaluation. In 2011 this improved to 70 % (n?=?167), which was a statistically significant difference, X ²(1)?=?5.13, p?=?0.02. By cancer site, ovarian cancer referrals also showed statistically significant improvement, X ²(1)?=?6.36, p?=?0.01. Breast and colon referrals were improved but not significant. Over 10 months, 129 patients were identified through the chart review program. Three were confirmed to have a genetic mutation for a hereditary cancer syndrome. An average week included review of 73 charts for 10 medical oncologists, 4 radiation oncologists, and 4 pediatric oncologists which generated 60–80 min of work for the genetic counselor. This program improved patient identification and quality, and allowed physicians to become more aware of opportunities for genetic counseling and more patients to receive genetic counseling and testing.     

Upregulation of hippocampal TrkB and synaptotagmin is involved in treadmill exercise-enhanced aversive memory in mice

Cognitive functions usually involve various synaptic proteins and neurotrophic factors in the hippocampus. However, whether treadmill exercise can improve learning and memory by upregulating some of these molecules remain unraveled. To address this question, male BALB/c mice were divided into control and exercise groups, the latter group went through 4 weeks of treadmill exercise training. At the end of exercise training period, they were either tested for passive avoidance (PA) performance or sacrificed for quantifying the hippocampal levels of brain-derived neurotrophic factor (BDNF), tropomyosin-related kinase B (TrkB, the BDNF receptor), synaptotagmin (a Ca²⁺-dependent synaptic vesicle protein), and SNAP-25 (a presynaptic vesicular fusion protein). Our results showed that treadmill exercise training (1) increased the retention latency without affecting the fear acquisition in the PA test, (2) transiently increased the hippocampal BDNF level at 1, 2, and 4 h after the completion of exercise training, and (3) persistently increased the hippocampal protein levels of full-length TrkB, phosphorylated TrkB and synaptotagmin, but not truncated TrkB or SNAP-25. Moreover, the protein expression level of full-length TrkB or synaptotagmin was positively correlated with PA performance in mice. Finally, inhibition of TrkB signaling by K252a abolished the exercise-facilitated PA performance and upregulation of TrkB and synaptotagmin. Taken together, these data suggest that the upregulation of TrkB and synaptotagmin in the hippocampus contributes to the exercise-facilitated aversive memory.     

A Methodological Examination of Emotion Inductions in Borderline Personality Disorder: A Comparison of Standardized Versus Idiographic Stimuli

Emotional reactivity is conceptualized as a core feature of borderline personality disorder (BPD) and has been subject to substantial empirical research. The laboratory methods used to elicit emotional reactivity in BPD have varied and findings across studies have been mixed. At present, there is little research evaluating the relative efficacy of different methods in eliciting emotional reactivity in BPD. Thus, the current study examined differences in emotional reactivity among individuals with BPD in response to standardized and idiographic stimuli, and across three specific emotions (sadness, fear, and anger). Individuals with BPD, social anxiety disorder, and healthy controls viewed film clips (i.e., standardized stimuli) or engaged in a personally-relevant imagery task (i.e., idiographic stimuli) while self-reported and physiological indices (skin conductance response and respiratory sinus arrhythmia) of emotion were collected. Results indicated that BPD participants displayed greater reactivity of sadness and anger (but not fear) in response to the idiographic versus standardized stimuli, a pattern that was not exhibited by the other two groups. These findings might explain some of the mixed evidence to date and suggest that idiographic sadness and fear inductions may be more effective for individuals with BPD.     

心理资本、学习策略与大学生学业成绩的关系

该研究采用《大学生学习策略问卷》和《积极心理资本问卷》对大学生4种学习策略和12种次级策略以及大学生的心理资本情况进行了调查,并在此基础上考察了大学生学习策略、心理资本与其学业成绩的关系。结果显示：大学生对认知、元认知、动机情感以及资源管理等4种学习策略总体掌握较好;在12种次级策略中,大学生对情绪调节、环境选择、过程监控等策略的掌握较好,而对意志努力、准备复述、学业求助等策略的掌握相对薄弱。大学生的心理资本总体情况是正面的,但也有约17%的大学生的心理资本水平偏低。大学生的心理资本和学习策略对其学业成绩有显著的预测作用,其中心理资本对其学业成绩的影响以学习策略为中介。