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Ammon-Treiber S Grecksch G Angelidis C Vezyraki P Höllt V Becker A 《Neurobiology of learning and memory》2008,90(2):358-364
The effects of inducible heat shock protein 70 (HSP70) on emotional and learning behaviour as well as hippocampal long-term potentiation was investigated in transgenic HSP70 overexpressing mice. In active two-way avoidance learning (shuttle box) as well as spatial 8-arm radial maze learning, the HSP70 overexpressing mice showed diminished learning performance. In several tests there was no indication of differences in anxiety behaviour between transgenic mice and wild-type mice. This suggests that impairment in learning behaviour is unrelated to the learning task and motivational aspects of behaviour. To investigate the neurophysiological correlate of learning, long-term potentiation experiments were performed. In transversal hippocampal slices, an enhanced amplitude of the population spike was found in HSP70 overexpressing mice. It was hypothesised that enhanced potentiation in conjunction with potentiation effects due to learning led to learning impairment. 相似文献
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Journal of Indian Council of Philosophical Research - The present education system is mainly object oriented material in nature but not subjective or spiritual. We study mainly subject viz. physic,... 相似文献
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Debasmita Patra 《Nanoethics》2011,5(2):143-157
There have been several conscious efforts made by different stakeholders in the area of nanoscience and nanotechnology to
increase the awareness of social and ethical issues (SEI) among its practitioners. But so far, little has been done at the
laboratory level to integrate a SEI component into the laboratory orientation schedule of practitioners. Since the laboratory
serves as the locus of activities of the scientific community, it is important to introduce SEI there to stimulate thinking
and discussion of SEI among practitioners, which would eventually contribute toward the responsible development of this technology.
In this article, through an example (at the Cornell NanoScale Science and Technology Facility (CNF), practitioners of which
represent a section of the nano researchers’ community in the USA), it is shown how a SEI component can be incorporated into
the laboratory orientation schedule of the practitioners from diverse disciplinary and institutional backgrounds. Results
show that, at CNF, the practitioners enjoyed the discussion since most of them learned about SEI for the first time in their
professional career. At the same time, some of them were also knowledgeable about SEI and contributed to the debates. Moreover,
the SEI orientation had significant positive impact on the scientific community enabling them to self-reflect upon their own
research and its implications for the wider society. This article also describes the efforts that were undertaken to disseminate
this form of SEI orientation to other 13 USA universities within the National Nanotechnology Infrastructure Network (NNIN,
one of the biggest networks funded from National Science Foundation for Nanotechnology research, of which CNF is a part).
As a result of this effort, most of the NNIN sites have already started or were in the process of integrating a SEI component
into their nanofabrication laboratories to make their users aware of SEI, ensuring eventual robust socio-technical integration
in the NNIN laboratories. In the future, this form of SEI orientation can also be disseminated to other nanofabrication laboratories
in the USA. 相似文献
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Many developing countries have allocated significant amounts of funding for nanoscience and nanotechnology research, yet compared
to developed countries, there has been little study, discussion, or debate over social and ethical issues. Using in-depth
interviews, this study focuses on the perceptions of practitioners, that is, scientists and engineers, in one developing country:
India. The disciplinary background, departmental affiliation, types of institutions, age, and sex of the practitioners varied
but did not appear to affect their responses. The results show that 95% of the Indian practitioners working in the area of
nanoscience and nanotechnology research recognized ethical issues in this research area, and 60% of them could offer specific
examples, which included possible ill effects on environment and human, use as a weapon, hype, professional ethics, laboratory
testing on animals, cyborgs, widening the gap between rich and poor, self-replication, and longevity of human life. The results
may offer opportunities for future cross-cultural research, as well as offer examples that can be used to raise the awareness
of other practitioners in India and elsewhere regarding the importance of ethical issues. 相似文献
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Reena Patra 《亚洲哲学》2006,16(3):199-218
This article aims to correlate Vaastu Shastra, an ancient Indian theory of architecture, with Heidegger's ‘Building, Dwelling and Thinking’ as they explain architecture in relation to the world where we live and build. Design as an evolutionary learning process is fundamentally a hermeneutic. Interestingly, some of the basic principles of Vaastu Shastra are coincidently similar to the points made by later Heidegger. As such, the main concern is to explain how man is related to the building and the universe, i.e. it establishes a relationship between man and nature. In this context, a dwelling place should be a place where environment is always suitable for human beings to live comfortably. In this article, first Vaastu Shastra is discussed, and then attention is drawn to the prominent parallels between Vaastu and Heidegger. 相似文献
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Journal of Indian Council of Philosophical Research - The present paper is based on the contention that there are two conceptions of the understanding of nature, nature as an object and nature as... 相似文献
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Journal of Indian Council of Philosophical Research - Since contemporary societies are deeply multicultural and plural, the partisan ideological politics obviously animate conflict of opinions and... 相似文献
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